Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin. (Q37333746)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24114838%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

title

Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin (English)

1 reference

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27 February 2020

1 reference

3

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27 February 2020

7

Douglas R Cavener

1 reference

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27 February 2020

author name string

Rong Wang

1

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27 February 2020

Barbara C McGrath

2

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27 February 2020

Michael W Roe

4

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27 February 2020

Xin Tang

5

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27 February 2020

Gong Chen

6

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27 February 2020

language of work or name

English

0 references

publication date

10 October 2013

1 reference

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Journal of Biological Chemistry

27 February 2020

published in

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27 February 2020

volume

288

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27 February 2020

issue

47

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27 February 2020

page(s)

33824-33836

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Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P

27 February 2020

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6 September 2017

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6 September 2017

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Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity

6 September 2017

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The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

6 September 2017

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Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

6 September 2017

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6 September 2017

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EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

6 September 2017

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Perk is essential for translational regulation and cell survival during the unfolded protein response

6 September 2017

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Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

6 September 2017

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Cytosolic phosphorylation of calnexin controls intracellular Ca(2+) oscillations via an interaction with SERCA2b

6 September 2017

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Autonomic regulation of islet hormone secretion--implications for health and disease

6 September 2017

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

6 September 2017

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Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

6 September 2017

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Relationship between presynaptic calcium current and postsynaptic potential in squid giant synapse

6 September 2017

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A model for receptor-regulated calcium entry

6 September 2017

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PERK activation at low glucose concentration is mediated by SERCA pump inhibition and confers preemptive cytoprotection to pancreatic β-cells

6 September 2017

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Rac-1 regulates nuclear factor of activated T cells (NFAT) C1 nuclear translocation in response to Fcepsilon receptor type 1 stimulation of mast cells

14 September 2017

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28 September 2017

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26 June 2018

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Role of calcineurin in inhibiting disadvantageous associations.

2 September 2018

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Reversible translocation of EYFP-tagged STIM1 is coupled to calcium influx in insulin secreting beta-cells

2 September 2018

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2 September 2018

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PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.

2 September 2018

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Visualizing calcium signaling in cells by digitized wide-field and confocal fluorescent microscopy.

2 September 2018

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PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis

2 September 2018

1 reference

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Dynamics of calcium clearance in mouse pancreatic beta-cells.

2 September 2018

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Store-operated influx of Ca(2+) in pancreatic beta-cells exhibits graded dependence on the filling of the endoplasmic reticulum.

2 September 2018

1 reference

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Store-operated Ca2+ entry in insulin-releasing pancreatic beta-cells

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24114838

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Neonatal diabetes mellitus

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24114838

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M113.503664

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24114838%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24114838%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1 reference