Are transgenic mice the 'alkahest' to understanding myocardial hypertrophy and failure? (Q37345653)

19 August 2017

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title

Are transgenic mice the 'alkahest' to understanding myocardial hypertrophy and failure? (English)

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19 August 2017

Stuart A Cook

1

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PubMed ID

19071133

19 August 2017

Angela Clerk

series ordinal

2

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PubMed ID

19071133

19 August 2017

Peter H Sugden

series ordinal

3

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19 August 2017

21 November 2008

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Journal of Molecular and Cellular Cardiology

19 August 2017

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19 August 2017

46

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19 August 2017

2

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19 August 2017

118-129

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Atrial natriuretic factor-SV40 T antigen transgenes produce tumors and cardiac arrhythmias in mice

19 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses

7 January 2021

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A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

7 January 2021

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Calcium-calcineurin signaling in the regulation of cardiac hypertrophy

7 January 2021

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Signaling path may lead to better heart-failure therapies

7 January 2021

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Using U0126 to dissect the role of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in the regulation of gene expression by endothelin-1 in cardiac myocytes.

7 January 2021

1 reference

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Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes

7 January 2021

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Generation of fertile cloned rats by regulating oocyte activation

7 January 2021

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Genetic manipulation of the rabbit heart via transgenesis

7 January 2021

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Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube

7 January 2021

1 reference

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Muscle creatine kinase sequence elements regulating skeletal and cardiac muscle expression in transgenic mice

7 January 2021

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A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

7 January 2021

1 reference

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Tissue-specific distribution and developmental regulation of M and B creatine kinase mRNAs

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Developmental regulation of myosin gene expression in mouse cardiac muscle

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals

7 January 2021

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Changes in myosin and creatine kinase mRNA levels with cardiac hypertrophy and hypothyroidism

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Transgenic Galphaq overexpression induces cardiac contractile failure in mice

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Transcriptional effects of chronic Akt activation in the heart.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Inappropriate splicing of a chimeric gene containing a large internal exon results in exon skipping in transgenic mice

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Size matters: use of YACs, BACs and PACs in transgenic animals

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

A mouse model of familial hypertrophic cardiomyopathy

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Steroid receptor fusion proteins for conditional activation of Raf-MEK-ERK signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Inducible activation of c-Myc in adult myocardium in vivo provokes cardiac myocyte hypertrophy and reactivation of DNA synthesis

7 January 2021

1 reference

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Studying gene function in eukaryotes by conditional gene inactivation

7 January 2021

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ErbB2 is essential in the prevention of dilated cardiomyopathy.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

7 January 2021

The renaissance of GSK3

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GSK3 takes centre stage more than 20 years after its discovery

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Glycogen synthase kinases 3alpha and 3beta in cardiac myocytes: regulation and consequences of their inhibition

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Glycogen synthase kinase-3beta -- actively inhibiting hypertrophy

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Blocking cardiac growth in hypertrophic cardiomyopathy induces cardiac dysfunction and decreased survival only in males.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Inhibition of glycogen synthase kinase 3beta during heart failure is protective

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Cardiac ryanodine receptor phosphorylation: target sites and functional consequences

7 January 2021

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Modulation of the ryanodine receptor and intracellular calcium

7 January 2021

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What are the consequences of phosphorylation and hyperphosphorylation of ryanodine receptors in normal and failing heart?

7 January 2021

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Three-dimensional visualization of FKBP12.6 binding to an open conformation of cardiac ryanodine receptor

7 January 2021

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Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy

7 January 2021

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FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

7 January 2021

1 reference

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Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase a.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression

7 January 2021

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Adrenergic regulation of cardiac contractility does not involve phosphorylation of the cardiac ryanodine receptor at serine 2808

7 January 2021

1 reference

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Intact beta-adrenergic response and unmodified progression toward heart failure in mice with genetic ablation of a major protein kinase A phosphorylation site in the cardiac ryanodine receptor

7 January 2021

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Regulation of ryanodine receptors in the heart

7 January 2021

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A HapMap harvest of insights into the genetics of common disease

7 January 2021

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Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes.

7 January 2021

1 reference

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Regulation of Ras·GTP Loading and Ras-Raf Association in Neonatal Rat Ventricular Myocytes by G Protein-coupled Receptor Agonists and Phorbol Ester

7 January 2021

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Analysis of guanine nucleotide bound to ras protein in PC12 cells

7 January 2021

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Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.

7 January 2021

1 reference

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The PI3K-PDK1 connection: more than just a road to PKB

7 January 2021

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7 January 2021

The two TORCs and Akt.

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Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Nuclear targeting of Akt enhances ventricular function and myocyte contractility

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy

7 January 2021

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p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

7 January 2021

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Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1.

7 January 2021

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Phenotyping hypertrophy: eschew obfuscation

7 January 2021

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The fuzzy logic of physiological cardiac hypertrophy

7 January 2021

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7 January 2021

1 reference

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Human cytomegalovirus - no longer just a DNA virus

7 January 2021

1 reference

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Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase.

7 January 2021

1 reference

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Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice

7 January 2021

1 reference

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Heritability and tissue specificity of expression quantitative trait loci

7 January 2021

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Transcriptional alterations in the left ventricle of three hypertensive rat models

7 January 2021

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Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass

7 January 2021

1 reference

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7 January 2021

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Cardiac response to pressure overload in 129S1/SvImJ and C57BL/6J mice: temporal- and background-dependent development of concentric left ventricular hypertrophy

7 January 2021

1 reference

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The heart of trained athletes: cardiac remodeling and the risks of sports, including sudden death

7 January 2021

1 reference

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A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy.

7 January 2021

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Peripartum cardiomyopathy: recent insights in its pathophysiology

7 January 2021

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Recovery from postpartum cardiomyopathy in 2 patients by blocking prolactin release with bromocriptine

7 January 2021

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Caution in the use of bromocriptine in peripartum cardiomyopathy

7 January 2021

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

7 January 2021

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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3-kinase--dependent pathway is cardioprotective

7 January 2021

1 reference

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Primary structure and functional expression from cDNA of the cardiac ryanodine receptor/calcium release channel.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.11.005

Chronic doxycycline exposure accelerates left ventricular hypertrophy and progression to heart failure in mice after thoracic aorta constriction

7 January 2021

1 reference

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DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility

7 January 2021

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Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation

7 January 2021

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10.1016/J.YJMCC.2008.11.005

7 January 2021

Identifiers

DOI

1 reference

19 August 2017

1 reference

PubMed ID

19071133