How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40. (Q37371276)

20 August 2017

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title

How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40. (English)

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20 August 2017

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James A DeCaprio

1

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PubMed ID

19150725

20 August 2017

language of work or name

English

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publication date

17 January 2009

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20 August 2017

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20 August 2017

384

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20 August 2017

2

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20 August 2017

274-284

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A conserved family of WD-40 proteins binds to the retinoblastoma protein in both plants and animals

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Cyclin A and the retinoblastoma gene product complex with a common transcription factor

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The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

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DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication

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Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

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Genetic origin of mutations predisposing to retinoblastoma

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Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product

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Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

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The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

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Phosphorylated CREB binds specifically to the nuclear protein CBP

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Cell cycle-specific association of E2F with the p130 E1A-binding protein

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A general theory of carcinogenesis

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Polyoma virus transforming protein associates with the product of the c-src cellular gene

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SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

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The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

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The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression

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Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

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Recruitment of TRRAP required for oncogenic transformation by E1A.

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Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement

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RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila

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The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus

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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

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An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates

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Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor

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Association of p300 and CBP with simian virus 40 large T antigen

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Tumors induced in hamsters by injection of rhesus monkey kidney cell extracts

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Identification of the oncogenic substance in rhesus monkey kidney cell culture as simian virus 40.

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Binding of cellular polypeptides to human adenovirus type 5 E1A proteins produced in Escherichia coli

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Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5.

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Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins

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An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120.

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Interaction between human cyclin A and adenovirus E1A-associated p107 protein

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Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes

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Clonal integration of a polyomavirus in human Merkel cell carcinoma

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Epigenetic reprogramming by adenovirus e1a.

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The p53 proto-oncogene can act as a suppressor of transformation

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Comparison of viral RNA sequences in adenovirus 2-transformed and lytically infected cells

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A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

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Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein

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The p400 complex is an essential E1A transformation target

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Structural evidence for the authenticity of the human retinoblastoma gene

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A viral mechanism for remodeling chromatin structure in G0 cells

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A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells

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A new component of the transcription factor DRTF1/E2F.

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Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma

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The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

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Transformation properties of type 5 adenovirus mutants that differentially express the E1A gene products

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Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A

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Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins

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Association of adenovirus early-region 1A proteins with cellular polypeptides

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Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex

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A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

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Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation

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The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F

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Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

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Adenovirus small e1a alters global patterns of histone modification

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Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis

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The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex

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Oncogenic effects in hamsters of human adenovirus types 12 and 18.

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Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

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Expression of transcription factor E2F1 induces quiescent cells to enter S phase

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A conserved region of unknown function participates in the recognition of E2F family members by the adenovirus E4 ORF 6/7 protein

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Induction of cellular DNA synthesis by purified adenovirus E1A proteins

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Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product

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Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

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In vitro mutagenesis of a putative DNA binding domain of SV40 large-T

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Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

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A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding

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Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen

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A novel general approach to eucaryotic mutagenesis functionally identifies conserved regions within the adenovirus 13S E1A polypeptide

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Initiation and maintenance of cell transformation by simian virus 40: a viral genetic property

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A protein kinase is present in a complex with adenovirus E1A proteins

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The retinoblastoma binding protein RBP2 is an H3K4 demethylase

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Mutation and cancer: statistical study of retinoblastoma

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A highly predictable animal model of retinoblastoma

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Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes

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E1A transcription induction: enhanced binding of a factor to upstream promoter sequences

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Identification of a cellular transcription factor involved in E1A trans-activation.

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Nuclear protein CBP is a coactivator for the transcription factor CREB

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An adenovirus E1A-like transcription factor is regulated during the differentiation of murine embryonal carcinoma stem cells

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The embryonal carcinoma stem cell Ela-like activity involves a differentiation-regulated transcription factor

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RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins

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Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation

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Isolation of human chromosome 13-specific DNA sequences cloned from flow sorted chromosomes and potentially linked to the retinoblastoma locus

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Oncogenic intelligence: Cell immortalization and transformation by the p53 gene

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An immunochemical investigation of SV40 T antigens. 1. Production properties and specificity of rabbit antibody to purified simian virus 40 large-T antigen

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The adenovirus E1A oncoprotein recruits the cellular TRRAP/GCN5 histone acetyltransferase complex

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Immunoprecipitation of protein kinase activity from adenovirus 5-infected cells using antiserum directed against tumour antigens

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Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor

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Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7

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Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

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Human retinoblastoma susceptibility gene: cloning, identification, and sequence.

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The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

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Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex

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The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E

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Binding and modulation of p53 by p300/CBP coactivators

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An adenovirus E1a protein region required for transformation and transcriptional repression

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Functional domains of adenovirus type 5 E1a proteins.

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SV40 large T antigen promotes dephosphorylation of p130.

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Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

7 January 2021

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Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence

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Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor

7 January 2021

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lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.

7 January 2021

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SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

7 January 2021

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The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T.

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Adenovirus-12 genes undetectable in human retinoblastoma

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The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

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Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication.

7 January 2021

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Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product

7 January 2021

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Complete transformation by adenovirus 2 requires both E1A proteins

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A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products

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Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Retinoblastoma protein partners

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Retinoblastoma-like neoplasm induced in C3H/BifB/Ki strain mice by human adenovirus serotype 12.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Retinal tumor induced in the baboon by human adenovirus 12.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Structural Basis for the Recognition of Histone H4 by the Histone-Chaperone RbAp46

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Distinct mammalian SWI/SNF chromatin remodeling complexes with opposing roles in cell-cycle control

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Mechanism of activation of early viral transcription by the adenovirus E1A gene product

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

The transcriptional coactivators p300 and CBP are histone acetyltransferases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

The human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Isolation of Mutants of an Animal Virus in Bacteria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

p53 targets simian virus 40 large T antigen for acetylation by CBP

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

A retinoblastoma-binding protein related to a negative regulator of Ras in yeast

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Characterization of human adenovirus type 5 early region 1A polypeptides using antitumor sera and an antiserum specific for the carboxy terminus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Formation of Different Cell–Virus Relationships in Tumour Cells Induced by Polyoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

p400 is required for E1A to promote apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Phosphorylation of polyoma T antigens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Regulation of SV40 large T-antigen stability by reversible acetylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Protein kinase activity associated with polyoma virus middle T antigen in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Characterization of different tumor antigens present in cells transformed by simian virus 40

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

The amino-terminal region of the adenovirus serotype 5 E1a protein performs two separate functions when expressed in primary baby rat kidney cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to esterase D

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

The release of growth arrest by microinjection of adenovirus E1A DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Repression of insulin gene expression by adenovirus type 5 E1a proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

The induction of neoplasms with a substance released from mouse tumors by tissue culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Simian virus 40 infection disrupts p130-E2F and p107-E2F complexes but does not perturb pRb-E2F complexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Species-specific elements in the large T-antigen J domain are required for cellular transformation and DNA replication by simian virus 40

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

The vacuolating virus, S.V. 40

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

In vitro phosphorylation of the tumor suppressor gene RB protein by mitosis-specific histone H1 kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

p55, the Drosophila ortholog of RbAp46/RbAp48, is required for the repression of dE2F2/RBF-regulated genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

An assay for cellular transformation by SV40

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

The quest for human cancer viruses.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Conserved functions of the pRB and E2F families

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Comparison of nucleotide sequences of the early E1a regions for subgroups A, B and C of human adenoviruses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Adenovirus E1a ras cooperation activity is separate from its positive and negative transcription regulatory functions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Adenovirus E1a proteins repress expression from polyomavirus early and late promoters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

VIRUS-CELL INTERACTION WITH A TUMOR-PRODUCING VIRUS

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Retinoblastoma in transgenic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

Inactivation of the retinoblastoma susceptibility protein is not sufficient for the transforming function of the conserved region 2-like domain of simian virus 40 large T antigen.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

7 January 2021

Uniform Nomenclature for Monoclonal Antibodies Directed Against Virus-Coded Proteins of Simian Virus 40 and Polyoma Virus

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

7 January 2021

Adenovirus E1A makes two distinct contacts with the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

7 January 2021

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

7 January 2021

E1a regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely related

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

7 January 2021

Lytic and transforming functions of individual products of the adenovirus E1A gene.

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

7 January 2021

Induction of malignancy in vitro in newborn hamster kidney tissue infected with simian vacuolating virus (SV40).

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

7 January 2021

The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

7 January 2021

Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

7 January 2021

Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FJ.VIROL.2008.12.010

7 January 2021

10.1016/J.VIROL.2008.12.010

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19150725