A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase. (Q37371679)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19561087%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

A portable hot spot recognition loop transfers sequence preferences from APOBEC family members to activation-induced cytidine deaminase (English)

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1 February 2020

1

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1 February 2020

Robert W. Maul

4

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1 February 2020

author name string

Shaun R Abrams

2

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1 February 2020

Kiran S Gajula

3

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1 February 2020

Patricia J Gearhart

5

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1 February 2020

James T Stivers

6

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1 February 2020

language of work or name

English

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publication date

26 June 2009

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Journal of Biological Chemistry

1 February 2020

published in

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1 February 2020

volume

284

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1 February 2020

page(s)

22898-22904

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1 February 2020

issue

34

1 reference

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Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications

1 February 2020

cites work

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6 September 2017

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6 September 2017

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Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

6 September 2017

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6 September 2017

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Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection

6 September 2017

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6 September 2017

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DNA deamination in immunity: AID in the context of its APOBEC relatives.

6 September 2017

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Discovery of activation-induced cytidine deaminase, the engraver of antibody memory

6 September 2017

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Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteins

6 September 2017

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6 September 2017

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Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities

6 September 2017

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The retroviral hypermutation specificity of APOBEC3F and APOBEC3G is governed by the C-terminal DNA cytosine deaminase domain

6 September 2017

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Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

6 September 2017

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APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo

6 September 2017

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Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G

6 September 2017

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A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination

6 September 2017

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Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome

6 September 2017

1 reference

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Use of the rpoB gene to determine the specificity of base substitution mutations on the Escherichia coli chromosome

6 September 2017

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RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators

6 September 2017

1 reference

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Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

6 September 2017

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

6 September 2017

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Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

6 September 2017

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Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

6 September 2017

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Elements in abasic site recognition by the major human and Escherichia coli apurinic/apyrimidinic endonucleases

6 September 2017

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G-->A hypermutation of the human immunodeficiency virus type 1 genome: evidence for dCTP pool imbalance during reverse transcription

6 September 2017

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Replacing the complementarity-determining regions in a human antibody with those from a mouse

6 September 2017

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Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase

6 September 2017

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C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.

14 September 2017

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The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice

14 September 2017

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Two levels of protection for the B cell genome during somatic hypermutation.

26 June 2018

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Biochemistry. Loop grafting and the origins of enzyme species.

2 September 2018

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2 September 2018

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Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity

2 September 2018

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The mutation spectrum of purified AID is similar to the mutability index in Ramos cells and in ung(-/-)msh2(-/-) mice

2 September 2018

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Methylation protects cytidines from AID-mediated deamination

2 September 2018

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Rapid evolution of primate antiviral enzyme APOBEC3G.

2 September 2018

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Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755697

Non-redundancy of cytidine deaminases in class switch recombination

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755697

DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755697

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2755697

Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.

2 September 2018

1 reference

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Codon bias targets mutation.

2 September 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.025536

21 January 2018

Identifiers

DOI

10.1074/JBC.M109.025536

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19561087%20AND%20SRC:MED&resulttype=core&format=json

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1 February 2020

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mapped directly with Wikidata item

24 November 2022

based on heuristic

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1 February 2020

1 reference