C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. (Q40627624)

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19 December 2019

title

C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion (English)

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19 December 2019

1

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Bernardo Reina San-Martin

19 December 2019

2

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19 December 2019

Almudena R Ramiro

3

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19 December 2019

author name string

Kevin M McBride

4

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19 December 2019

Michel C Nussenzweig

5

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19 December 2019

publication date

1 August 2003

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19 December 2019

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19 December 2019

volume

12

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19 December 2019

issue

2

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19 December 2019

page(s)

501-508

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Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion

19 December 2019

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Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity

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Probing immunoglobulin gene hypermutation with microsatellites suggests a nonreplicative short patch DNA synthesis process

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Ku80 is required for immunoglobulin isotype switching

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Transcription-targeted DNA deamination by the AID antibody diversification enzyme

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Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

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AID mediates hypermutation by deaminating single stranded DNA.

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De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination

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The RAG proteins and V(D)J recombination: complexes, ends, and transposition

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RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators

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AID is essential for immunoglobulin V gene conversion in a cultured B cell line

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DNA deamination mediates innate immunity to retroviral infection

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Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination

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The role of DNA repair in somatic hypermutation of immunoglobulin genes

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Hypermutation of HIV-1 DNA in the Absence of the Vif Protein

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Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

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Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

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7 January 2021

Mechanism and control of class-switch recombination

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Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif

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Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

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Germ line maintenance of the pseudogene donor pool for somatic immunoglobulin gene conversion in chickens

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7 January 2021

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

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7 January 2021

Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation

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7 January 2021

Enhancement of estrogen receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation function 2 in determining estrogen receptor pharmacology

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7 January 2021

The AID enzyme induces class switch recombination in fibroblasts

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7 January 2021

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

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7 January 2021

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

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7 January 2021

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

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7 January 2021

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

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7 January 2021

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

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7 January 2021

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

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7 January 2021

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation

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7 January 2021

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

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7 January 2021

A hyperconversion mechanism generates the chicken light chain preimmune repertoire

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7 January 2021

Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

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7 January 2021

The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.

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7 January 2021

Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation

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7 January 2021

Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern

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7 January 2021

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

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7 January 2021

The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

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7 January 2021

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Identifiers

DOI

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19 December 2019

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