Paths of FGFR-driven tumorigenesis (Q37381550)

20 August 2017

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title

Paths of FGFR-driven tumorigenesis (English)

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20 August 2017

Victor D Acevedo

1

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PubMed ID

19182515

20 August 2017

Michael Ittmann

series ordinal

2

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PubMed ID

19182515

20 August 2017

David M Spencer

series ordinal

3

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20 August 2017

18 February 2009

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20 August 2017

9

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inferred from page(s)

published in

Cell Cycle

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20 August 2017

8

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20 August 2017

4

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20 August 2017

580-588

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PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer

20 August 2017

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12 December 2020

Normal and abnormal development of the male urogenital tract. Role of androgens, mesenchymal-epithelial interactions, and growth factors

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12 December 2020

The expression of Sprouty1, an inhibitor of fibroblast growth factor signal transduction, is decreased in human prostate cancer.

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12 December 2020

The transcriptional control of trunk neural crest induction, survival, and delamination

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12 December 2020

Role of androgens and fibroblast growth factors in prostatic development

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12 December 2020

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family

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12 December 2020

Fibroblast growth factors

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12 December 2020

Pten inactivation and the emergence of androgen-independent prostate cancer.

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12 December 2020

Demonstration of fibroblast growth factor receptor-I in human prostate by polymerase chain reaction and immunohistochemistry

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12 December 2020

Characterization of the FGF axis and identification of a novel FGFR1iiic isoform during prostate cancer progression in the TRAMP model

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12 December 2020

NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.

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12 December 2020

p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation

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12 December 2020

The heparan sulfate-fibroblast growth factor family: diversity of structure and function.

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12 December 2020

Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer

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12 December 2020

The epithelial-mesenchymal transition generates cells with properties of stem cells

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12 December 2020

Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis

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12 December 2020

Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor

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12 December 2020

Alterations in expression of basic fibroblast growth factor (FGF) 2 and its receptor FGFR-1 in human prostate cancer

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12 December 2020

FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

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12 December 2020

The current state of hormonal therapy for prostate cancer

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12 December 2020

Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells.

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12 December 2020

Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function

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12 December 2020

Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos.

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12 December 2020

Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs

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12 December 2020

Anti-tumor angiogenesis therapy using soluble receptors: enhanced inhibition of tumor growth when soluble fibroblast growth factor receptor-1 is used with soluble vascular endothelial growth factor receptor.

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12 December 2020

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

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12 December 2020

Differential expression of specific FGF ligand and receptor isoforms during angiogenesis associated with prostate cancer progression

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12 December 2020

Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.

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12 December 2020

Fibroblast growth factors, their receptors and signaling

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12 December 2020

Somatic oncogenic mutations, benign skin lesions and cancer progression: where to look next?

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12 December 2020

Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk

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12 December 2020

Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis

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12 December 2020

Prospective identification of tumorigenic breast cancer cells

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12 December 2020

Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation

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12 December 2020

Complex networks orchestrate epithelial-mesenchymal transitions

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12 December 2020

Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy

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12 December 2020

Fibroblast growth factor-10. A second candidate stromal to epithelial cell andromedin in prostate

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12 December 2020

Selective over-expression of fibroblast growth factor receptors 1 and 4 in clinical prostate cancer.

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12 December 2020

The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition

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12 December 2020

Inhibition of fibroblast growth factor/fibroblast growth factor receptor activity in glioma cells impedes tumor growth by both angiogenesis-dependent and -independent mechanisms

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12 December 2020

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation

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12 December 2020

Molecular definition of breast tumor heterogeneity

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12 December 2020

Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition

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12 December 2020

Isolation and functional characterization of murine prostate stem cells

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12 December 2020

Cell signaling by receptor tyrosine kinases

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12 December 2020

Chronic activity of ectopic type 1 fibroblast growth factor receptor tyrosine kinase in prostate epithelium results in hyperplasia accompanied by intraepithelial neoplasia

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12 December 2020

HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.

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12 December 2020

Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer

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12 December 2020

Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

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12 December 2020

Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction

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12 December 2020

Prostate cancer in a transgenic mouse

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12 December 2020

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

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12 December 2020

Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations

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12 December 2020

Structural basis for fibroblast growth factor receptor activation

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12 December 2020

Conditional activation of FGFR1 in the prostate epithelium induces angiogenesis with concomitant differential regulation of Ang-1 and Ang-2.

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12 December 2020

Regulation of androgen receptor activity by tyrosine phosphorylation.

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12 December 2020

Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas.

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12 December 2020

aFGF immunoreactivity in prostate cancer and its co-localization with bFGF and FGF8

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12 December 2020

Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer

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12 December 2020

FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity

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12 December 2020

Fibroblast growth factor receptor 2 limits and receptor 1 accelerates tumorigenicity of prostate epithelial cells

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12 December 2020

Stem Cells and Cancer: Two Faces of Eve

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12 December 2020

Distinct role of macrophages in different tumor microenvironments

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12 December 2020

Spred is a Sprouty-related suppressor of Ras signalling

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12 December 2020

Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development

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12 December 2020

From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells

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12 December 2020

FGF Signaling Regulates Mesoderm Cell Fate Specification and Morphogenetic Movement at the Primitive Streak

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12 December 2020

Role of epithelial cell fibroblast growth factor receptor substrate 2alpha in prostate development, regeneration and tumorigenesis

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12 December 2020

Downregulation of Sef, an inhibitor of receptor tyrosine kinase signaling, is common to a variety of human carcinomas

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12 December 2020

Epithelial-mesenchymal transitions in tumour progression

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12 December 2020

Murine cell lines derived from Pten null prostate cancer show the critical role of PTEN in hormone refractory prostate cancer development

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12 December 2020

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

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12 December 2020

Directionally specific paracrine communication mediated by epithelial FGF9 to stromal FGFR3 in two-compartment premalignant prostate tumors

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12 December 2020

Basic fibroblast growth factor levels in cancer cells and in sera of patients suffering from proliferative disorders of the prostate

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12 December 2020

Molecular requirements for epithelial-mesenchymal transition during tumor progression

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12 December 2020

In vivo and in vitro evidence for transforming growth factor-beta1-mediated epithelial to mesenchymal transition in esophageal adenocarcinoma.

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12 December 2020

Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor

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12 December 2020

Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor

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12 December 2020

SOX9 is expressed in normal prostate basal cells and regulates androgen receptor expression in prostate cancer cells

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12 December 2020

The biology of VEGF and its receptors

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12 December 2020

Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors

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12 December 2020

FGFR1 and WT1 are markers of human prostate cancer progression

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12 December 2020

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

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12 December 2020

A critical role for the inflammatory response in a mouse model of preneoplastic progression

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12 December 2020

Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence

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12 December 2020

Modulation of signalling by Sprouty: a developing story

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12 December 2020

Expression of bFGF/FGFR-1 and vascular proliferation related to clinicopathologic features and tumor progress in localized prostate cancer

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12 December 2020

Fibroblast growth factor signaling in tumorigenesis

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12 December 2020

Association of fibroblast growth factor receptor-1 with c-Src correlates with association between c-Src and cortactin

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12 December 2020

FGF8 isoform b expression in human prostate cancer

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12 December 2020

Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

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12 December 2020

Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity

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12 December 2020

Fibroblast growth factor 2 promotes tumor progression in an autochthonous mouse model of prostate cancer.

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12 December 2020

A secreted FGF-binding protein can serve as the angiogenic switch in human cancer.

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12 December 2020

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition

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12 December 2020

Complementary and coordinated roles of the VEGFs and angiopoietins during normal and pathologic vascular formation

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12 December 2020

Cross-talk between the androgen receptor and the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer

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12 December 2020

Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells

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12 December 2020

A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase.

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12 December 2020

Fibroblast growth factor-2-induced host stroma reaction during initial tumor growth promotes progression of mouse melanoma via vascular endothelial growth factor A-dependent neovascularization

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12 December 2020

Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

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12 December 2020

Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity

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12 December 2020

Tumour-educated macrophages promote tumour progression and metastasis

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12 December 2020

Modulation of tumor angiogenesis by conditional expression of fibroblast growth factor-2 affects early but not established tumors.

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12 December 2020

Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases

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12 December 2020

Generation of a prostate from a single adult stem cell

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12 December 2020

Increased expression of FGF-8 isoforms and FGF receptors in human premalignant prostatic intraepithelial neoplasia lesions and prostate cancer

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12 December 2020

The transcriptional repressor Snail promotes mammary tumor recurrence

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12 December 2020

Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway

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12 December 2020

Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses

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12 December 2020

FGF8 over-expression in prostate cancer is associated with decreased patient survival and persists in androgen independent disease

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12 December 2020

Tumorigenesis and the angiogenic switch

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12 December 2020

The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors

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12 December 2020

Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.

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12 December 2020

Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis

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12 December 2020

Expression of FGF and FGF receptor genes in human breast cancer

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12 December 2020

The role of fibroblast growth factors and their receptors in prostate cancer.

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12 December 2020

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12 December 2020

The development of androgen-independent prostate cancer

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12 December 2020

Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice

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12 December 2020

FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.

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12 December 2020

Epigenetic inactivation of the human sprouty2 (hSPRY2) homologue in prostate cancer.

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12 December 2020

Suppression of solid tumor growth by immunoneutralizing monoclonal antibody against human basic fibroblast growth factor

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12 December 2020

Identifiers

DOI

10.4161/CC.8.4.7657

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20 August 2017

0 references

1 reference

PubMed ID

19182515