Genetics and molecular pathophysiology of Na(v)1.7-related pain syndromes (Q37382551)

20 August 2017

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title

Genetics and molecular pathophysiology of Na(v)1.7-related pain syndromes (English)

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20 August 2017

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Sulayman D Dib-Hajj

1

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PubMed ID

19185186

20 August 2017

Yong Yang

series ordinal

2

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PubMed ID

19185186

20 August 2017

Stephen G Waxman

series ordinal

3

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20 August 2017

1 January 2008

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20 August 2017

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20 August 2017

63

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20 August 2017

85-110

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Regulation of the voltage-gated cardiac sodium channel Nav1.5 by interacting proteins.

20 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

A stop codon mutation in SCN9A causes lack of pain sensation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Cloning of a sodium channel alpha subunit from rabbit Schwann cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Na(v)1.7 sodium channel expression in human lingual nerve neuromas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Molecular identities of two tetrodotoxin-resistant sodium channels in corneal axons.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Spinal sensory neurons express multiple sodium channel alpha-subunit mRNAs.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Sodium channel Na(v)1.6 is expressed along nonmyelinated axons and it contributes to conduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Mutation of a new sodium channel gene, Scn8a, in the mouse mutant ‘motor endplate disease’

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Neuromodulation of Na+ channels: an unexpected form of cellular plasticity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

1 reference

7 January 2021

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Biophysical properties of human Na v1.7 splice variants and their regulation by protein kinase A.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Mutation I136V alters electrophysiological properties of the Na(v)1.7 channel in a family with onset of erythromelalgia in the second decade

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Inherited erythermalgia: limb pain from an S4 charge-neutral Na channelopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Plasticity of TTX-sensitive sodium channels PN1 and brain III in injured human nerves

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

An SCN9A channelopathy causes congenital inability to experience pain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Changes of sodium channel expression in experimental painful diabetic neuropathy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Slow closed-state inactivation: a novel mechanism underlying ramp currents in cells expressing the hNE/PN1 sodium channel.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Nav1.3 sodium channels: rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

The roles of sodium channels in nociception: Implications for mechanisms of pain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

NaN/Nav1.9: a sodium channel with unique properties

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

From genes to pain: Na v 1.7 and human pain disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Functional analysis of a voltage-gated sodium channel and its splice variant from rat dorsal root ganglia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Identification and characterization of the promoter region of the Nav1.7 voltage-gated sodium channel gene (SCN9A).

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Clinical characteristics and pathophysiology of erythromelalgia and erythermalgia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Erythromelalgia and erythermalgia: diagnostic differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Thrombocythemic erythromelalgia, primary erythermalgia, and secondary erythermalgia: three distinct clinicopathologic entities

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

The primary erythermalgia-susceptibility gene is located on chromosome 2q31-32.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

SCN9A mutations define primary erythermalgia as a neuropathic disorder of voltage gated sodium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

1 reference

7 January 2021

The presence and role of the tetrodotoxin-resistant sodium channel Na(v)1.9 (NaN) in nociceptive primary afferent neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

trkA is expressed in nociceptive neurons and influences electrophysiological properties via Nav1.8 expression in rapidly conducting nociceptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

What's in a name--familial rectal pain syndrome becomes paroxysmal extreme pain disorder

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Paroxysmal extreme pain disorder (previously familial rectal pain syndrome)

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Autosomal dominant erythromelalgia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Nomenclature of voltage-gated sodium channels

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Ibuprofen blocks changes in Na v 1.7 and 1.8 sodium channels associated with complete Freund's adjuvant-induced inflammation in rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Sporadic onset of erythermalgia: a gain-of-function mutation in Nav1.7.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Na(V)1.7 mutant A863P in erythromelalgia: effects of altered activation and steady-state inactivation on excitability of nociceptive dorsal root ganglion neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Rectal, ocular, and submaxillary pain; a familial autonomic disorder related to proctalgia fugaz: report of a family

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Distinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Phosphorylation of sodium channel Na(v)1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

The changes in expression of three subtypes of TTX sensitive sodium channels in sensory neurons after spinal nerve ligation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Changes in three subtypes of tetrodotoxin sensitive sodium channel expression in the axotomized dorsal root ganglion in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Accumulation of PN1 and PN3 sodium channels in painful human neuroma-evidence from immunocytochemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Size matters: Erythromelalgia mutation S241T in Nav1.7 alters channel gating

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Characterization of a familial case with primary erythromelalgia from Taiwan.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

CAP-1A is a novel linker that binds clathrin and the voltage-gated sodium channel Na(v)1.8

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Autosomal dominant erythermalgia associated with a novel mutation in the voltage-gated sodium channel alpha subunit Nav1.7.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Congenital insensitivity to pain: an update

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

A case of inherited erythromelalgia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Subtype-selective sodium channel blockers promise a new era of pain research

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Na(v)1.7 and Na(v)1.3 are the only tetrodotoxin-sensitive sodium channels expressed by the adult guinea pig enteric nervous system.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Compound heterozygosity in sodium channel Nav1.7 in a family with hereditary erythermalgia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Early events in node of Ranvier formation during myelination and remyelination in the PNS

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

A novel, abundant sodium channel expressed in neurons and glia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Familial rectal pain: a type of reflex epilepsy?

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons after sciatic nerve injury but not rhizotomy.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Cloning and characterization of a mouse sensory neuron tetrodotoxin-resistant voltage-gated sodium channel gene, Scn10a

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

A case of primary erythermalgia, wintry hypothermia and encephalopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Hereditary erythermalgia and acquired erythromelalgia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Novel clustering of sodium channel Na(v)1.1 with ankyrin-G and neurofascin at discrete sites in the inner plexiform layer of the retina.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Recent advances in hereditary sensory and autonomic neuropathies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Fire and phantoms after spinal cord injury: Na+ channels and central pain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Elevated expression of type II Na+ channels in hypomyelinated axons of shiverer mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Localization of the type VI voltage-gated sodium channel protein in human CNS.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Comparative distribution of voltage-gated sodium channel proteins in human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Voltage-gated sodium channels and pain pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Decrease in inflammatory hyperalgesia by herpes vector-mediated knockdown of Nav1.7 sodium channels in primary afferents

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Mutation hotspots of SCN9A in primary erythermalgia

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: evidence for a role in pain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2808%2901004-3

7 January 2021

10.1016/S0065-2660(08)01004-3

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19185186