Targeting the protein kinase C family in the diabetic kidney: lessons from analysis of mutant mice (Q37399929)

20 August 2017

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title

Targeting the protein kinase C family in the diabetic kidney: lessons from analysis of mutant mice (English)

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20 August 2017

M Meier

1

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PubMed ID

19238353

20 August 2017

J Menne

series ordinal

2

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PubMed ID

19238353

20 August 2017

H Haller

series ordinal

3

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20 August 2017

24 February 2009

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20 August 2017

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20 August 2017

52

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20 August 2017

5

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20 August 2017

765-775

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https://scigraph.springernature.com/pub.10.1007/s00125-009-1278-y

20 August 2017

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Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse

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Protein kinase C as a therapeutic target

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Reactive oxygen species and matrix remodeling in diabetic kidney

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Radical approach to diabetic nephropathy

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Protein kinase Cbeta inhibition attenuates osteopontin expression, macrophage recruitment, and tubulointerstitial injury in advanced experimental diabetic nephropathy

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Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection

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Regulation of protein kinase C by short term hyperglycaemia in human platelets in vivo and in vitro.

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12 December 2020

Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase C-alpha-dependent pathway.

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Ruboxistaurin: LY 333531

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Immunodeficiency in protein kinase cbeta-deficient mice

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Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells

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Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice.

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Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta

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From hyperglycemia to diabetic kidney disease: the role of metabolic, hemodynamic, intracellular factors and growth factors/cytokines

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The molecular heterogeneity of protein kinase C and its implications for cellular regulation

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12 December 2020

Protein kinase C activity is acutely regulated by plasma glucose concentration in human monocytes in vivo.

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12 December 2020

Activation of protein kinase C by elevation of glucose concentration: proposal for a mechanism in the development of diabetic vascular complications

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12 December 2020

PKC-beta is not necessary for cardiac hypertrophy

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12 December 2020

Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

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12 December 2020

Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice

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12 December 2020

Selective protein kinase C inhibitors and their applications

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12 December 2020

Nailing down PKC isoform specificity in diabetic nephropathy two's company, three's a crowd.

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12 December 2020

(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta

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12 December 2020

Knockout of PKC alpha enhances insulin signaling through PI3K

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12 December 2020

The pathobiology of diabetic complications: a unifying mechanism

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Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function

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12 December 2020

Protein kinase Cδ controls self-antigen-induced B-cell tolerance

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Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor

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12 December 2020

The effect of ruboxistaurin on nephropathy in type 2 diabetes

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Kidney outcomes in long-term studies of ruboxistaurin for diabetic eye disease

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Protein kinase C beta inhibition: A novel therapeutic strategy for diabetic microangiopathy

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Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype

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A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice

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Deletion of protein kinase C-epsilon signaling pathway induces glomerulosclerosis and tubulointerstitial fibrosis in vivo.

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Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy

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Kidney disease in diabetology: lessons from 2007.

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Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes

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Use of genetic mouse models in the study of diabetic nephropathy

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Effect of ruboxistaurin on the visual acuity decline associated with long-standing diabetic macular edema

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12 December 2020

The role of protein kinase C activation in diabetic nephropathy

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12 December 2020

Identification of PKC-isoform-specific biological actions using pharmacological approaches

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12 December 2020

Protein kinase C isozymes as potential therapeutic targets in immune disorders

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12 December 2020

Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody

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12 December 2020

Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-alpha-deficient diabetic mice

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12 December 2020

The life and death of protein kinase C.

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12 December 2020

Abnormalities in protein kinase C and MAP kinase cascade in mesangial cells cultured under high glucose conditions

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12 December 2020

Oxidative stress as a major culprit in kidney disease in diabetes

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12 December 2020

Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway

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12 December 2020

Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats

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12 December 2020

PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning.

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12 December 2020

The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: initial results of the Protein Kinase C beta Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized cl

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12 December 2020

Cellular mechanisms and treatment of diabetes vascular complications converge on reactive oxygen species

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12 December 2020

Role of zeta PKC in B-cell signaling and function

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12 December 2020

Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose

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12 December 2020

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats

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12 December 2020

Protein kinase C-beta inhibition: a promise not yet fulfilled

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12 December 2020

Effect of ruboxistaurin on urinary transforming growth factor-beta in patients with diabetic nephropathy and type 2 diabetes

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12 December 2020

High glucose-suppressed endothelin-1 Ca2+ signaling via NADPH oxidase and diacylglycerol-sensitive protein kinase C isozymes in mesangial cells

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12 December 2020

Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivo.

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12 December 2020

Protein kinase C isozymes and the regulation of diverse cell responses

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12 December 2020

Increased renal gene transcription of protein kinase C-beta in human diabetic nephropathy: relationship to long-term glycaemic control

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12 December 2020

Mouse models of diabetic nephropathy

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12 December 2020

Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy

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12 December 2020

Protein kinase C and lipid signaling for sustained cellular responses

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12 December 2020

Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice.

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12 December 2020

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12 December 2020

Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes

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12 December 2020

Effect of ruboxistaurin in patients with diabetic macular edema: thirty-month results of the randomized PKC-DMES clinical trial

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12 December 2020

Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial

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12 December 2020

Clinical safety of the selective PKC-beta inhibitor, ruboxistaurin

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12 December 2020

Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD(P)H oxidase

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12 December 2020

Functional PKC in vivo analysis using deficient mouse models

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12 December 2020

Protein kinase C isozymes and their selectivity towards ruboxistaurin

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12 December 2020

Proteinuria in diabetic kidney disease: a mechanistic viewpoint

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12 December 2020

Deletion of protein kinase C-beta isoform in vivo reduces renal hypertrophy but not albuminuria in the streptozotocin-induced diabetic mouse model

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12 December 2020

Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients

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12 December 2020

Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes

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12 December 2020

Progress in gene targeting: using mutant mice to study renal function and disease

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12 December 2020

Protein kinase C activation and its role in kidney disease

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12 December 2020

Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor alpha.

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12 December 2020

Protein kinase C in human renal cell carcinomas: role in invasion and differential isoenzyme expression

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12 December 2020

Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension

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12 December 2020

10.1007/S00125-009-1278-Y

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19238353