Assembly and structure of protein phosphatase 2A. (Q37412348)

20 August 2017

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title

Assembly and structure of protein phosphatase 2A. (English)

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20 August 2017

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YiGong Shi

1

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PubMed ID

19277525

20 August 2017

language of work or name

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1 February 2009

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Science in China. Series C: Life Sciences

20 August 2017

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20 August 2017

52

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20 August 2017

135-146

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20 August 2017

2

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https://scigraph.springernature.com/pub.10.1007/s11427-009-0018-3

20 August 2017

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Structure of the protein phosphatase 2A holoenzyme

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Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins

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Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits

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Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p

21 January 2018

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Protein phosphatase 2A subunit assembly: the catalytic subunit carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen

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Structure of a Protein Phosphatase 2A Holoenzyme: Insights into B55-Mediated Tau Dephosphorylation

21 January 2018

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Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2

21 January 2018

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The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis

21 January 2018

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Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo

21 January 2018

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Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue

21 January 2018

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Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression

21 January 2018

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Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells

21 January 2018

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alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure

21 January 2018

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Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein

21 January 2018

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The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

21 January 2018

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Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme

21 January 2018

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Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40

21 January 2018

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Structural Basis of PP2A Inhibition by Small t Antigen

21 January 2018

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Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus

21 January 2018

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Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: abundant expression of both forms in cells

21 January 2018

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Control of protein phosphatase 2A by simian virus 40 small-t antigen

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Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen

21 January 2018

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Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the A alpha subunit gene

21 January 2018

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Alterations of the PPP2R1B gene in human lung and colon cancer

21 January 2018

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Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene

21 January 2018

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Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

21 January 2018

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Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants

21 January 2018

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Shugoshin collaborates with protein phosphatase 2A to protect cohesin

21 January 2018

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Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

21 January 2018

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PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation

21 January 2018

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Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha

21 January 2018

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Crystal structure of a beta-catenin/Tcf complex

21 January 2018

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Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A.

21 January 2018

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Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A.

21 January 2018

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Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55/B).

21 January 2018

1 reference

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A century of Alzheimer's disease

21 January 2018

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Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

21 January 2018

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Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies.

21 January 2018

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Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

21 January 2018

1 reference

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Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

A protein factor essential for microtubule assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

Tubulin requires tau for growth onto microtubule initiating sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

Carboxymethylation of nuclear protein serine/threonine phosphatase X

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

A novel assay for protein phosphatase 2A (PP2A) complexes in vivo reveals differential effects of covalent modifications on different Saccharomyces cerevisiae PP2A heterotrimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

Structural mechanism of demethylation and inactivation of protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

Spatial control of protein phosphatase 2A (de)methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

Generation of active protein phosphatase 2A is coupled to holoenzyme assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

Structure and mechanism of the phosphotyrosyl phosphatase activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

Isolation and characterization of a tyrosyl phosphatase activator from rabbit skeletal muscle and Xenopus laevis oocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

The phosphotyrosyl phosphatase activator of protein phosphatase 2A. A novel purification method, immunological and enzymic characterization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

Overlapping binding sites in protein phosphatase 2A for association with regulatory A and alpha-4 (mTap42) subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcmeurin and phosphatase-2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

Inactivation and Activation of Liver Phosphorylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11427-009-0018-3

10.1007/S11427-009-0018-3

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19277525