BET bromodomain protein inhibition is a therapeutic option for medulloblastoma. (Q37420196)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24231268%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

BET bromodomain protein inhibition is a therapeutic option for medulloblastoma (English)

1 reference

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29 February 2020

0 references

4

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29 February 2020

7

Frank Speleman

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29 February 2020

author name string

Anton Henssen

1

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29 February 2020

Theresa Thor

2

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29 February 2020

Andrea Odersky

3

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29 February 2020

Nicolai El-Hindy

5

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29 February 2020

Anneleen Beckers

6

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29 February 2020

Kristina Althoff

8

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29 February 2020

Simon Schäfers

9

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29 February 2020

Alexander Schramm

10

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29 February 2020

Ulrich Sure

11

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29 February 2020

Gudrun Fleischhack

12

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29 February 2020

Angelika Eggert

13

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29 February 2020

Johannes H Schulte

14

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29 February 2020

language of work or name

English

0 references

publication date

1 November 2013

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29 February 2020

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29 February 2020

volume

4

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29 February 2020

page(s)

2080-2095

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29 February 2020

issue

11

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The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

29 February 2020

cites work

1 reference

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The repair and signaling responses to DNA double-strand breaks

23 August 2017

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Targeting MYCN in neuroblastoma by BET bromodomain inhibition

23 August 2017

1 reference

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Inhibition of BET bromodomain targets genetically diverse glioblastoma

23 August 2017

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The requirement for cyclin D function in tumor maintenance

23 August 2017

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Novel mutations target distinct subgroups of medulloblastoma.

23 August 2017

1 reference

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Functional genomics identifies therapeutic targets for MYC-driven cancer

23 August 2017

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Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas

23 August 2017

1 reference

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The p53 network: cellular and systemic DNA damage responses in aging and cancer

23 August 2017

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Molecular subgroups of medulloblastoma: the current consensus

23 August 2017

1 reference

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

23 August 2017

1 reference

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MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma

23 August 2017

1 reference

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

23 August 2017

1 reference

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Challenging issues in pediatric oncology

23 August 2017

1 reference

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c-MYC expression sensitizes medulloblastoma cells to radio- and chemotherapy and has no impact on response in medulloblastoma patients

23 August 2017

1 reference

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Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome

23 August 2017

1 reference

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Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables

23 August 2017

1 reference

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Selective inhibition of BET bromodomains

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875771

Medulloblastoma comprises four distinct molecular variants

23 August 2017

1 reference

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Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription

23 August 2017

1 reference

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Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875771

The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription

23 August 2017

1 reference

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Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875771

The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875771

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

23 August 2017

1 reference

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Elongation by RNA polymerase II: the short and long of it

23 August 2017

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23 August 2017

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Linking the epigenetic 'language' of covalent histone modifications to cancer

23 August 2017

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Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

23 August 2017

1 reference

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MDM2 overexpression is associated with short survival in adults with medulloblastoma

23 August 2017

1 reference

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Cytogenetics and molecular genetics of childhood brain tumors

23 August 2017

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You bet-cha: a novel family of transcriptional regulators

23 August 2017

1 reference

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The language of covalent histone modifications

23 August 2017

1 reference

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Identification and characterization of BRDT: A testis-specific gene related to the bromodomain genes RING3 and Drosophila fsh.

23 August 2017

1 reference

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Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis

23 August 2017

1 reference

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HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875771

Galectin-1 is a major effector of TrkB-mediated neuroblastoma aggressiveness.

6 September 2017

1 reference

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Incidence and trends in pediatric malignancies medulloblastoma/primitive neuroectodermal tumor: a SEER update. Surveillance Epidemiology and End Results

14 September 2017

1 reference

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Negative autoregulation of c-myc transcription

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875771

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875771

Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875771

Adult medulloblastoma comprises three major molecular variants.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875771

P-TEFb is a crucial co-factor for Myc transactivation.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875771

RankProd: a bioconductor package for detecting differentially expressed genes in meta-analysis

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3875771

3 December 2018

Identifiers

DOI

10.18632/ONCOTARGET.1534

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24231268%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24231268%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24231268%20AND%20SRC:MED&resulttype=core&format=json