Coordination between polymerase beta and FEN1 can modulate CAG repeat expansion. (Q37459997)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19674974%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Coordination between polymerase beta and FEN1 can modulate CAG repeat expansion (English)

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5 February 2020

7

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5 February 2020

6

Cynthia T McMurray

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5 February 2020

author name string

Yuan Liu

1

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5 February 2020

Rajendra Prasad

2

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5 February 2020

William A Beard

3

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5 February 2020

Esther W Hou

4

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5 February 2020

Julie K Horton

5

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5 February 2020

language of work or name

English

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publication date

11 August 2009

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Journal of Biological Chemistry

5 February 2020

published in

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5 February 2020

volume

284

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5 February 2020

issue

41

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5 February 2020

page(s)

28352-28366

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Base excision repair of oxidative DNA damage and association with cancer and aging

5 February 2020

cites work

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HMGB1 is a cofactor in mammalian base excision repair

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OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

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Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability

23 August 2017

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Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability

23 August 2017

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Long CTG Tracts from the Myotonic Dystrophy Gene Induce Deletions and Rearrangements during Recombination at the APRT Locus in CHO Cells

23 August 2017

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Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

23 August 2017

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Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavage

23 August 2017

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Dramatic mutation instability in HD mouse striatum: does polyglutamine load contribute to cell-specific vulnerability in Huntington's disease?

23 August 2017

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Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1

23 August 2017

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Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats

23 August 2017

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Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice

23 August 2017

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Stability of the human fragile X (CGG)(n) triplet repeat array in Saccharomyces cerevisiae deficient in aspects of DNA metabolism

23 August 2017

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Functional and physical interaction between WRN helicase and human replication protein A

23 August 2017

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DNA secondary structure: a common and causative factor for expansion in human disease

23 August 2017

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Triplet repeats form secondary structures that escape DNA repair in yeast

23 August 2017

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Molecular basis of genetic instability of triplet repeats

23 August 2017

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The characterization of a mammalian DNA structure-specific endonuclease

23 August 2017

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Proliferating cell nuclear antigen-dependent abasic site repair in Xenopus laevis oocytes: an alternative pathway of base excision DNA repair

23 August 2017

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Trinucleotide repeats that expand in human disease form hairpin structures in vitro

23 August 2017

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Assignment of the gene for human DNA polymerase alpha to the X chromosome

23 August 2017

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DNA ligase I competes with FEN1 to expand repetitive DNA sequences in vitro

23 August 2017

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Substrate binding by human apurinic/apyrimidinic endonuclease indicates a Briggs-Haldane mechanism

23 August 2017

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Single-stranded DNA-binding protein in vitro eliminates the orientation-dependent impediment to polymerase passage on CAG/CTG repeats

23 August 2017

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Nucleotide excision repair affects the stability of long transcribed (CTG*CAG) tracts in an orientation-dependent manner in Escherichia coli

14 September 2017

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Recombination-induced CAG trinucleotide repeat expansions in yeast involve the MRE11-RAD50-XRS2 complex

14 September 2017

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FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair.

28 September 2017

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Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA.

28 September 2017

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Trinucleotide repeats in neurogenetic disorders

28 September 2017

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Requirement of mammalian DNA polymerase-beta in base-excision repair.

28 September 2017

1 reference

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Triplet repeat expansion generated by DNA slippage is suppressed by human flap endonuclease 1.

28 September 2017

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Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells.

26 June 2018

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Somatic instability of the CTG repeat in mice transgenic for the myotonic dystrophy region is age dependent but not correlated to the relative intertissue transcription levels and proliferative capacities.

26 June 2018

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Purification and domain-mapping of mammalian DNA polymerase beta.

26 June 2018

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Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer.

26 June 2018

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Androgen receptor and vitamin D receptor gene polymorphisms and prostate cancer risk.

2 September 2018

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Long-patch base excision DNA repair of 2-deoxyribonolactone prevents the formation of DNA-protein cross-links with DNA polymerase beta

2 September 2018

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DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair

2 September 2018

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Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis

2 September 2018

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Analysis of human flap endonuclease 1 mutants reveals a mechanism to prevent triplet repeat expansion

2 September 2018

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Weak strand displacement activity enables human DNA polymerase beta to expand CAG/CTG triplet repeats at strand breaks

2 September 2018

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Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease

2 September 2018

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Trinucleotide expansion in haploid germ cells by gap repair

2 September 2018

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Dramatic, expansion-biased, age-dependent, tissue-specific somatic mosaicism in a transgenic mouse model of triplet repeat instability.

2 September 2018

1 reference

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Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps

2 September 2018

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Larger expansions of the CTG repeat in muscle compared to lymphocytes from patients with myotonic dystrophy

2 September 2018

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12 December 2020

Oxidative DNA damage in the aging mouse brain

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12 December 2020

Protection against methylation-induced cytotoxicity by DNA polymerase beta-dependent long patch base excision repair

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12 December 2020

Inhibition of flap endonuclease 1 by flap secondary structure and relevance to repeat sequence expansion

1 reference

12 December 2020

Evidence for an imino intermediate in the DNA polymerase beta deoxyribose phosphate excision reaction

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12 December 2020

Expansion and length-dependent fragility of CTG repeats in yeast

1 reference

12 December 2020

Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism

1 reference

12 December 2020

Influence of hairpins on template reannealing at trinucleotide repeat duplexes: a model for slipped DNA

1 reference

12 December 2020

Mammalian base excision repair and DNA polymerase beta

1 reference

12 December 2020

Analysis of base excision DNA repair of the oxidative lesion 2-deoxyribonolactone and the formation of DNA-protein cross-links

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12 December 2020

Ribonuclease dicer cleaves triplet repeat hairpins into shorter repeats that silence specific targets

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12 December 2020

Identifiers

DOI

10.1074/JBC.M109.050286

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19674974%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19674974%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference