Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis (Q37465347)

20 August 2017

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis (English)

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20 August 2017

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endoplasmic reticulum

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Jared R Mayers

3

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Ebru Erbay

object named as

Ebru Erbay

1

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Liza Makowski

object named as

Liza Makowski

4

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Gökhan Hotamışlıgil

11

object named as

Gökhan S Hotamisligil

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20 August 2017

5

Khanichi N Charles

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20 August 2017

Vladimir R Babaev

2

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20 August 2017

Melinda E Snitow

6

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20 August 2017

Sergio Fazio

7

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20 August 2017

Michelle M Wiest

8

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20 August 2017

Steven M Watkins

9

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20 August 2017

Macrae F Linton

10

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20 August 2017

language of work or name

English

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publication date

29 November 2009

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20 August 2017

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20 August 2017

15

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20 August 2017

1383-1391

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20 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nm.2067

20 August 2017

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cites work

Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss

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Nutrient sensing and inflammation in metabolic diseases

23 August 2017

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Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism

23 August 2017

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Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis

23 August 2017

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Regulation of hepatic lipogenesis by the transcription factor XBP1

23 August 2017

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Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

23 August 2017

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Adipocyte/macrophage fatty acid binding proteins in metabolic syndrome

23 August 2017

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Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease

23 August 2017

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Signal integration in the endoplasmic reticulum unfolded protein response

23 August 2017

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Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2

23 August 2017

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SREBP-1c transcription factor and lipid homeostasis: clinical perspective

23 August 2017

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Inflammation and metabolic disorders

23 August 2017

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Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

23 August 2017

1 reference

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Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation

23 August 2017

1 reference

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Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

23 August 2017

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The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation

23 August 2017

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A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease

23 August 2017

1 reference

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Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency

23 August 2017

1 reference

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The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities

23 August 2017

1 reference

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

23 August 2017

1 reference

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XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

23 August 2017

1 reference

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Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta

23 August 2017

1 reference

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Lipotoxicity: when tissues overeat

23 August 2017

1 reference

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Triglyceride accumulation protects against fatty acid-induced lipotoxicity

23 August 2017

1 reference

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Stearoyl-CoA desaturase, a short-lived protein of endoplasmic reticulum with multiple control mechanisms

23 August 2017

1 reference

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Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia

23 August 2017

1 reference

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Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors

23 August 2017

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Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis

23 August 2017

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Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols

23 August 2017

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Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

23 August 2017

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Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice

23 August 2017

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LXR-dependent gene expression is important for macrophage survival and the innate immune response

23 August 2017

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Improved glucose and lipid metabolism in genetically obese mice lacking aP2.

23 August 2017

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Modulation of ligand binding affinity of the adipocyte lipid-binding protein by selective mutation. Analysis in vitro and in situ.

23 August 2017

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Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid

23 August 2017

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Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice

6 September 2017

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Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis

14 September 2017

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Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790330

The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790330

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

14 September 2017

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Molecular differences caused by differentiation of 3T3-L1 preadipocytes in the presence of either dehydroepiandrosterone (DHEA) or 7-oxo-DHEA.

26 June 2018

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Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2.

26 June 2018

1 reference

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Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.

2 September 2018

1 reference

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The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790330

Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein

2 September 2018

1 reference

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Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

2 September 2018

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12 December 2020

GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis

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12 December 2020

Monocytic origin of foam cells in human atherosclerotic plaques

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12 December 2020

Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome

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12 December 2020

https://api.crossref.org/works/10.1038%2FNM.2067

1 reference

7 January 2021

inferred from DOI database lookup

Improved Glucose and Lipid Metabolism in Genetically Obese Mice Lacking aP2

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.2067

7 January 2021

inferred from DOI database lookup

On the use of permutation in and the performance of a class of nonparametric methods to detect differential gene expression.

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.2067

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NM.2067

1 reference

20 August 2017

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20 August 2017

1 reference