Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells (Q40024663)

16 September 2017

Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells (English)

1 reference

16 September 2017

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1 reference

Michael B Wheeler

3

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author name string

Elida Lai

1

1 reference

PubMed ID

18198352

16 September 2017

George Bikopoulos

2

1 reference

PubMed ID

18198352

16 September 2017

Maria Rozakis-Adcock

4

1 reference

PubMed ID

18198352

16 September 2017

Allen Volchuk

5

1 reference

16 September 2017

15 January 2008

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American Journal of Physiology - Endocrinology and Metabolism

16 September 2017

1 reference

16 September 2017

294

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16 September 2017

E540-50

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16 September 2017

3

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Metabolic engineering with recombinant adenoviruses

16 September 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Glucagon-like peptide-1 prevents beta cell glucolipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Troglitazone does not protect rat pancreatic beta cells against free fatty acid-induced cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

The role of stearoyl-CoA desaturase in the control of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Pleiotropic effects of fatty acids on pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Transcriptional and translational control in the Mammalian unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Stearoyl-CoA desaturase, a short-lived protein of endoplasmic reticulum with multiple control mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Decreasing IRS-2 expression in pancreatic β-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Palmitate-induced apoptosis can occur through a ceramide-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Adverse physicochemical properties of tripalmitin in beta cells lead to morphological changes and lipotoxicity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

The standardization of pancreatic donors for islet isolations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Roles of CHOP/GADD153 in endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Translational control in the endoplasmic reticulum stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Role of nitric oxide in obesity-induced beta cell disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Ceramide involvement in apoptosis and apoptotic diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

Signaling the unfolded protein response from the endoplasmic reticulum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00478.2007

10.1152/AJPENDO.00478.2007

21 January 2018

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