Is multiple sclerosis a mitochondrial disease? (Q37466077)

20 August 2017

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title

Is multiple sclerosis a mitochondrial disease? (English)

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20 August 2017

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Peizhong Mao

1

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20 August 2017

P Hemachandra Reddy

series ordinal

2

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20 August 2017

language of work or name

English

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publication date

14 July 2009

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Biochimica et Biophysica Acta

20 August 2017

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20 August 2017

1802

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20 August 2017

1

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20 August 2017

66-79

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Oxidative damage to DNA in plaques of MS brains

20 August 2017

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12 December 2020

Mitochondrial mutation in Iranian patients with multiple sclerosis, correlation between haplogroups H, A and clinical manifestations

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12 December 2020

The genetics of multiple sclerosis: SNPs to pathways to pathogenesis

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12 December 2020

A mitochondrial component of neurodegeneration in multiple sclerosis

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12 December 2020

Programmed cell death mechanisms in neurological disease

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12 December 2020

Axonal damage in acute multiple sclerosis lesions

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12 December 2020

Combination therapy with interferon beta-1a and doxycycline in multiple sclerosis: an open-label trial

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12 December 2020

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

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12 December 2020

Systemic progesterone administration results in a partial reversal of the age-associated decline in CNS remyelination following toxin-induced demyelination in male rats

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12 December 2020

Association of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosus

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12 December 2020

Preactive lesions in multiple sclerosis

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12 December 2020

Drug targets in severe acute respiratory syndrome (SARS) virus and other coronavirus infections

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12 December 2020

Autophagy: a lysosomal degradation pathway with a central role in health and disease

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12 December 2020

Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathology

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12 December 2020

The complex genetic aetiology of multiple sclerosis

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12 December 2020

Autophagy induction and autophagic cell death in effector T cells

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12 December 2020

Phenytoin protects central axons in experimental autoimmune encephalomyelitis

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12 December 2020

Actions of neurotrophic factors and their signaling pathways in neuronal survival and axonal regeneration

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12 December 2020

Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death

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12 December 2020

The effect of Ginkgo biloba on functional measures in multiple sclerosis: a pilot randomized controlled trial.

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12 December 2020

Cerebrospinal fluid evidence of increased extra-mitochondrial glucose metabolism implicates mitochondrial dysfunction in multiple sclerosis disease progression

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12 December 2020

The history of multiple sclerosis: the changing frame of the disease over the centuries

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12 December 2020

The activation of protein kinase C induces higher production of reactive oxygen species by mononuclear cells in patients with multiple sclerosis than in controls

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12 December 2020

Increased cerebrospinal fluid and plasma levels of ultraweak chemiluminescence are associated with changes in the thiol pool and lipid-soluble fluorescence in multiple sclerosis: the pathogenic role of oxidative stress.

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12 December 2020

MRI aspects of the "inflammatory phase" of multiple sclerosis.

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12 December 2020

Reactive nitrogen intermediates in human neuropathology: an overview

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12 December 2020

Mitochondrial DNA repair in aging and disease

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12 December 2020

Bench to bedside: tempering antigen-presenting cells in multiple sclerosis

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12 December 2020

Magnetic resonance studies of abnormalities in the normal appearing white matter and grey matter in multiple sclerosis

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12 December 2020

An Iranian herbal-marine medicine, MS14, ameliorates experimental allergic encephalomyelitis.

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12 December 2020

Pathogenesis of axonal and neuronal damage in multiple sclerosis

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12 December 2020

Mitochondrial medicine for aging and neurodegenerative diseases

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12 December 2020

Neuroinvasion by human respiratory coronaviruses

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12 December 2020

The Nogo signaling pathway for regeneration block

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12 December 2020

Antioxidants in multiple sclerosis: do they have a role in therapy?

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12 December 2020

Mitochondrial dysfunction in aging and Alzheimer's disease: strategies to protect neurons

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12 December 2020

IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production

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12 December 2020

Multiple sclerosis: etiology and treatment strategies.

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12 December 2020

Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models.

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12 December 2020

Oxidative stress in neurodegenerative diseases

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12 December 2020

A novel method for assessing sex-specific and genotype-specific response to injury in astrocyte culture

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12 December 2020

Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells

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12 December 2020

Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

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12 December 2020

Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection

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12 December 2020

Mitochondria in multiple sclerosis.

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12 December 2020

Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria

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12 December 2020

A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells

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12 December 2020

Oxidative stress, glutamate, and neurodegenerative disorders

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12 December 2020

Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain

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12 December 2020

Axonal transection in the lesions of multiple sclerosis

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12 December 2020

Mortality from multiple sclerosis and exposure to residential and occupational solar radiation: a case-control study based on death certificates

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12 December 2020

Diagnosis and treatment of multiple sclerosis

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12 December 2020

ReviewDoes the “Hygiene Hypothesis” Provide an Explanation for the High Prevalence of Multiple Sclerosis in Sardinia?

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12 December 2020

Mitochondrial changes within axons in multiple sclerosis

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12 December 2020

Reactive oxygen species and peroxisomes: struggling for balance

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12 December 2020

Leber's hereditary optic neuropathy mitochondrial DNA mutations in familial multiple sclerosis

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12 December 2020

Transcriptional activity by cocaine-amphetamine-regulated transcript

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12 December 2020

Protease-activated receptors in the brain: receptor expression, activation, and functions in neurodegeneration and neuroprotection

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12 December 2020

Nitric oxide irreversibly inhibits cytochrome oxidase at low oxygen concentrations: evidence for inverse oxygen concentration-dependent peroxynitrite formation

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12 December 2020

Nitric oxide and mitochondrial complex IV.

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12 December 2020

Elevated protein carbonylation in the brain white matter and gray matter of patients with multiple sclerosis

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12 December 2020

Free radicals and antioxidants in normal physiological functions and human disease

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12 December 2020

Gray matter involvement in multiple sclerosis

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12 December 2020

Mitochondrial DNA repair: a critical player in the response of cells of the CNS to genotoxic insults

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12 December 2020

Overexpression of CNTF in Mesenchymal Stem Cells reduces demyelination and induces clinical recovery in experimental autoimmune encephalomyelitis mice

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12 December 2020

Multiple sclerosis--the plaque and its pathogenesis

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12 December 2020

Increase of uric acid and purine compounds in biological fluids of multiple sclerosis patients

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12 December 2020

Targeting repair proteins to the mitochondria of mammalian cells through stable transfection, transient transfection, viral transduction, and TAT-mediated protein transduction

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12 December 2020

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

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12 December 2020

'The marvellous harmony of the nervous parts': the origins of multiple sclerosis.

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12 December 2020

Epstein-barr virus: environmental trigger of multiple sclerosis?

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12 December 2020

Sodium channels and multiple sclerosis: roles in symptom production, damage and therapy.

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12 December 2020

Oxidative stress and neurotoxicity

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12 December 2020

Back to the future with ubiquitin

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12 December 2020

The ubiquitin system: pathogenesis of human diseases and drug targeting

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12 December 2020

Variations in mitochondrial DNA copy numbers in MS brains

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12 December 2020

Chaperone-mediated pathway of proteasome regulatory particle assembly

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12 December 2020

Neuroprotection and neuroregeneration in multiple sclerosis

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12 December 2020

The biology of CNS remyelination: the key to therapeutic advances.

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12 December 2020

Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research.

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12 December 2020

Is the mitochondrial DNA involved in determining susceptibility to multiple sclerosis?

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12 December 2020

Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives

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12 December 2020

Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis.

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12 December 2020

Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin-induced CNS demyelination

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12 December 2020

Gender hormones: role in the pathogenesis of central nervous system disease and demyelination

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12 December 2020

A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes

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12 December 2020

The ubiquitin system.

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12 December 2020

Post-mortem MRI-guided sampling of multiple sclerosis brain lesions: increased yield of active demyelinating and (p)reactive lesions

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12 December 2020

CART peptide promotes the survival of hippocampal neurons by upregulating brain-derived neurotrophic factor

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12 December 2020

Oxidative stress induces degradation of mitochondrial DNA

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12 December 2020

Identification of a novel risk locus for multiple sclerosis at 13q31.3 by a pooled genome-wide scan of 500,000 single nucleotide polymorphisms

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12 December 2020

Autophagic stress in neuronal injury and disease.

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12 December 2020

mtDNA nt13708A variant increases the risk of multiple sclerosis

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12 December 2020

Remyelination in the CNS: from biology to therapy

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12 December 2020

Modelling of multiple sclerosis: lessons learned in a non-human primate

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12 December 2020

Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis

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12 December 2020

Genetic variants of Complex I in multiple sclerosis

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12 December 2020

Gender and sex hormones in multiple sclerosis pathology and therapy.

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12 December 2020

Oxidative stress and Parkinson's disease

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12 December 2020

Immunomodulatory treatment strategies in multiple sclerosis

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12 December 2020

Autophagy in neuroprotection and neurodegeneration: A question of balance.

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12 December 2020

Clinical, pathological, and immunologic aspects of the multiple sclerosis model in common marmosets (Callithrix jacchus).

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12 December 2020

Revised estimate of the prevalence of multiple sclerosis in the united states

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12 December 2020

The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy

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12 December 2020

Demyelination: the role of reactive oxygen and nitrogen species

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12 December 2020

Oxidative stress in serum and peripheral blood leukocytes in patients with different disease courses of multiple sclerosis

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12 December 2020

Glatiramer acetate treatment in PPMS: why males appear to respond favorably.

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12 December 2020

Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis.

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12 December 2020

Oxidative stress and neurodegeneration: where are we now?

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12 December 2020

Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis

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12 December 2020

Neuronal degeneration and mitochondrial dysfunction

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12 December 2020

Mitoxantrone: a review of its use in multiple sclerosis

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12 December 2020

Myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the common marmoset reflects the immunopathology of pattern II multiple sclerosis lesions

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12 December 2020

Pathway and network-based analysis of genome-wide association studies in multiple sclerosis

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12 December 2020

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12 December 2020

IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).

1 reference

12 December 2020

Cognitive impairment in multiple sclerosis: evidence-based analysis and recommendations.

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12 December 2020

Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis

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12 December 2020

Angiogenesis in life, disease and medicine

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12 December 2020

Leber's hereditary optic neuropathy mutations in Korean patients with multiple sclerosis

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12 December 2020

Severe oxidative damage in multiple sclerosis lesions coincides with enhanced antioxidant enzyme expression

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12 December 2020

Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor 1,4-anthracenediones.

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12 December 2020

Imaging correlates of decreased axonal Na+/K+ ATPase in chronic multiple sclerosis lesions.

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12 December 2020

Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination

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12 December 2020

LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis

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12 December 2020

Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice

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12 December 2020

Immunological update on multiple sclerosis

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12 December 2020

Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta

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12 December 2020

Axonal dysfunction in chronic multiple sclerosis: meltdown in the membrane

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12 December 2020

Complementary and alternative medicine for MS

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12 December 2020

CNTF is a major protective factor in demyelinating CNS disease: A neurotrophic cytokine as modulator in neuroinflammation

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12 December 2020

Association of infectious mononucleosis with multiple sclerosis. A population-based study.

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12 December 2020

Mitochondrial respiratory-chain diseases

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12 December 2020

A review of complementary and alternative medicine (CAM) by people with multiple sclerosis

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12 December 2020

Mitochondria take center stage in aging and neurodegeneration

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12 December 2020

Multiple sclerosis: an immune or neurodegenerative disorder?

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12 December 2020

How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis

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12 December 2020

Animal models of multiple sclerosis

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12 December 2020

Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system.

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12 December 2020

Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation.

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12 December 2020

Role of P450 aromatase in sex-specific astrocytic cell death

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12 December 2020

Depression and multiple sclerosis: Review of a lethal combination

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12 December 2020

Hexameric assembly of the proteasomal ATPases is templated through their C termini

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12 December 2020

Elevated myeloperoxidase activity in white matter in multiple sclerosis.

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12 December 2020

Multiple sclerosis and mitochondrial myopathy: An unusual combination of diseases

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12 December 2020

Architecture of succinate dehydrogenase and reactive oxygen species generation

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12 December 2020

Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis

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12 December 2020

Remyelination in multiple sclerosis: a new role for neurotrophins?

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12 December 2020

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

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12 December 2020

The trials and errors in MS therapy

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12 December 2020

Complementary and alternative medicine: is there a role in multiple sclerosis?

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12 December 2020

Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE.

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12 December 2020

Axonal loss in normal-appearing white matter in a patient with acute MS.

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12 December 2020

Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis.

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12 December 2020

Axonal conduction and injury in multiple sclerosis: the role of sodium channels

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12 December 2020

Risk alleles for multiple sclerosis identified by a genomewide study

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12 December 2020

Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis.

1 reference

12 December 2020

Grey matter pathology in clinically early multiple sclerosis: evidence from magnetic resonance imaging

1 reference

12 December 2020

Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis

1 reference

12 December 2020

Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions

1 reference

12 December 2020

A potential role for estrogen in experimental autoimmune encephalomyelitis and multiple sclerosis

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12 December 2020

CD45 (PTPRC) as a candidate gene in multiple sclerosis

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12 December 2020

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

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12 December 2020

Recent clinical trials and future therapies

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12 December 2020

Occurrence of a multiple sclerosis-like illness in women who have a Leber's hereditary optic neuropathy mitochondrial DNA mutation

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12 December 2020

The prevalence of multiple sclerosis in the world: an update

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12 December 2020

Combination therapies for multiple sclerosis: scientific rationale, clinical trials, and clinical practice

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12 December 2020

Na+ - and K+-dependent adenosine triphosphatase changes in multiple sclerosis plaques

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12 December 2020

Synthetic Peptide dendrimers block the development and expression of experimental allergic encephalomyelitis

1 reference

12 December 2020

Treatment with selective estrogen receptor modulators regulates myelin specific T-cells and suppresses experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Association of a common polymorphism in the promoter of UCP2 with susceptibility to multiple sclerosis

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12 December 2020

Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis

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12 December 2020

Epstein-Barr virus in the development of multiple sclerosis

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12 December 2020

A complex II defect affects mitochondrial structure, leading to ced-3- and ced-4-dependent apoptosis and aging

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12 December 2020

Glial inhibition of CNS axon regeneration

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12 December 2020

Uric acid protects against secondary damage after spinal cord injury

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12 December 2020

The immunogenetics of multiple sclerosis

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12 December 2020

Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis

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12 December 2020

Treatment of established relapsing experimental autoimmune encephalomyelitis with the proteasome inhibitor PS-519

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12 December 2020

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12 December 2020

T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

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12 December 2020

Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains

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12 December 2020

Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients

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12 December 2020

Investigation of the role of mitochondrial DNA in multiple sclerosis susceptibility

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12 December 2020

Sex ratio of multiple sclerosis in Canada: a longitudinal study.

1 reference

12 December 2020

Virus-induced autoimmunity: epitope spreading to myelin autoepitopes in Theiler's virus infection of the central nervous system

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12 December 2020

Growth factors and myelin regeneration in multiple sclerosis

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12 December 2020

Debris clearance by microglia: an essential link between degeneration and regeneration.

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12 December 2020

Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences

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12 December 2020

Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult

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12 December 2020

Human respiratory coronavirus OC43: genetic stability and neuroinvasion

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12 December 2020

Mitochondrial DNA variants in Bulgarian patients affected by multiple sclerosis

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12 December 2020

Axonal degeneration and progressive neurologic disability in multiple sclerosis

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12 December 2020

[Study on immunological pathogenesis of 59 patients with multiple sclerosis of different TCM syndrome types]

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12 December 2020

Review: Mitochondria and disease progression in multiple sclerosis

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12 December 2020

Another way to die: autophagic programmed cell death

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12 December 2020

Nitric oxide, a novel biologic messenger

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12 December 2020

The role of nitric oxide in multiple sclerosis

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12 December 2020

Strength, skeletal muscle composition, and enzyme activity in multiple sclerosis

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12 December 2020

Mitochondrial mechanism of neuroprotection by CART

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12 December 2020

Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger.

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12 December 2020

Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity

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12 December 2020

Nitric oxide toxicity in CNS white matter: an in vitro study using rat optic nerve

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12 December 2020

No association of the 11778 mitochondrial DNA mutation and multiple sclerosis in Japan

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12 December 2020

Oligodendrocyte development and the onset of myelination in the human fetal brain

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12 December 2020

Antioxidant therapy in multiple sclerosis.

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12 December 2020

Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis

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12 December 2020

An in Vitro Model of Oligodendrocyte Destruction by Nitric Oxide and Its Relevance to Multiple Sclerosis

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12 December 2020

Mitochondrial oxidative damage in aging and Alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics

1 reference

12 December 2020

10.1016/J.BBADIS.2009.07.002

Identifiers

DOI

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20 August 2017

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20 August 2017

PubMed publication ID

19607913

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