5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity (Q37530219)

20 August 2017

5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity (English)

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20 August 2017

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3 June 2020

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Marla Gearing

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3 June 2020

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Peter T Nelson

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3 June 2020

author name string

Yunting Lin

2

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3 June 2020

R Craig Street

3

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3 June 2020

Li Lin

4

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3 June 2020

Qing Dai

5

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3 June 2020

Li Yu

6

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3 June 2020

Han Bao

7

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3 June 2020

James J Lah

9

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3 June 2020

Chuan He

11

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3 June 2020

Allan I Levey

12

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3 June 2020

Jennifer G Mullé

13

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3 June 2020

Ranhui Duan

14

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3 June 2020

Peng Jin

15

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3 June 2020

publication date

9 April 2016

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20 August 2017

Human Molecular Genetics

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3 June 2020

volume

25

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3 June 2020

issue

12

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3 June 2020

page(s)

2437-2450

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describes a project that uses

3 June 2020

Cytoscape

1 reference

9 June 2022

https://europepmc.org/search?query=(METHODS:'Cytoscape')

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

1 reference

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Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

23 August 2017

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5-Hydroxymethylcytosine: A new player in brain disorders?

23 August 2017

1 reference

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Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain.

23 August 2017

1 reference

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Diversity of two forms of DNA methylation in the brain.

23 August 2017

1 reference

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Drosophila melanogaster as a model organism for Alzheimer's disease

23 August 2017

1 reference

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

23 August 2017

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U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease

23 August 2017

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Epigenetic changes in the progression of Alzheimer's disease

23 August 2017

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diffReps: detecting differential chromatin modification sites from ChIP-seq data with biological replicates

23 August 2017

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Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease

23 August 2017

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Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients.

23 August 2017

1 reference

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Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

23 August 2017

1 reference

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5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients

23 August 2017

1 reference

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University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology

23 August 2017

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A unique regulatory phase of DNA methylation in the early mammalian embryo

23 August 2017

1 reference

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Dynamics of DNA methylation in aging and Alzheimer's disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

The Human Epigenome Browser at Washington University

23 August 2017

1 reference

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National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Autosomal recessive causes likely in early-onset Alzheimer disease

23 August 2017

1 reference

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Functional screening of Alzheimer pathology genome-wide association signals in Drosophila

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology

23 August 2017

1 reference

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Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates

23 August 2017

1 reference

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Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

23 August 2017

1 reference

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Cytoscape 2.8: new features for data integration and network visualization

23 August 2017

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Tau reduction prevents Abeta-induced defects in axonal transport.

23 August 2017

1 reference

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Cytoscape Web: an interactive web-based network browser

23 August 2017

1 reference

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Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

23 August 2017

1 reference

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Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

23 August 2017

1 reference

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Alzheimer's disease: insights from Drosophila melanogaster models

23 August 2017

1 reference

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Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Drosophila melanogaster as a model organism of brain diseases

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

TopHat: discovering splice junctions with RNA-Seq

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Epigenetic changes in Alzheimer's disease: decrements in DNA methylation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

A human phenome-interactome network of protein complexes implicated in genetic disorders

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

A survey of human disease gene counterparts in the Drosophila genome

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Comparative genomics of the eukaryotes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Alzheimer's disease genetics: from the bench to the clinic

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Genetic insights in Alzheimer's disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Do epigenetic pathways initiate late onset Alzheimer disease (LOAD): towards a new paradigm.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Epigenetics in Alzheimer's disease: a focus on DNA modifications

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Alzheimer's disease: the challenge of the second century

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5181627

2 September 2018

Identifiers

DOI

10.1093/HMG/DDW109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27060332%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27060332%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

27060332

1 reference