T cell epitope: friend or foe? Immunogenicity of biologics in context (Q37556764)

21 August 2017

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title

T cell epitope: friend or foe? Immunogenicity of biologics in context (English)

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21 August 2017

Lenny Moise

4

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Anne Searls De Groot

object named as

Anne S De Groot

6

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Matthew T Ardito

3

object named as

Matt Ardito

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21 August 2017

Constanze A Weber

1

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21 August 2017

Preema J Mehta

2

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21 August 2017

Bill Martin

5

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21 August 2017

language of work or name

English

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publication date

18 July 2009

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Advanced Drug Delivery Reviews

21 August 2017

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21 August 2017

61

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21 August 2017

11

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21 August 2017

965-976

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High-affinity T helper epitope induces complementary helper and APC polarization, increased CTL, and protection against viral infection

21 August 2017

1 reference

12 December 2020

Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen

1 reference

12 December 2020

B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab

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12 December 2020

Natural versus adaptive regulatory T cells

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12 December 2020

Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors

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12 December 2020

De-immunization of therapeutic proteins by T-cell epitope modification.

1 reference

12 December 2020

Detection of IGA anti-OKT3 antibodies in OKT3-treated transplant recipients

1 reference

12 December 2020

CAMPATH-1H, a humanized monoclonal antibody, in refractory rheumatoid arthritis. An intravenous dose-escalation study

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12 December 2020

Self-representation in the thymus: an extended view

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12 December 2020

Analyzing Mycobacterium tuberculosis proteomes for candidate vaccine epitopes.

1 reference

12 December 2020

Resuscitating adaptive Tregs with combination therapies?

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12 December 2020

Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide

1 reference

12 December 2020

Immunogenicity of protein therapeutics

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12 December 2020

Preparation of a non-immunogenic arginase by the covalent attachment of polyethylene glycol

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12 December 2020

Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion

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12 December 2020

Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products

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12 December 2020

Immune epitope database analysis resource (IEDB-AR).

1 reference

12 December 2020

Pivotal study of iodine I 131 tositumomab for chemotherapy-refractory low-grade or transformed low-grade B-cell non-Hodgkin's lymphomas.

1 reference

12 December 2020

Immunogenicity of engineered antibodies

1 reference

12 December 2020

Reducing risk, improving outcomes: bioengineering less immunogenic protein therapeutics

1 reference

12 December 2020

Rituximab anti-CD20 monoclonal antibody therapy in non-Hodgkin's lymphoma: safety and efficacy of re-treatment

1 reference

12 December 2020

A single helper T cell clone is sufficient to commit polyclonal naive B cells to produce pathogenic IgG in experimental pemphigus vulgaris.

1 reference

12 December 2020

Recombinant staphylokinase variants with altered immunoreactivity. I: Construction and characterization

1 reference

12 December 2020

Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells.

1 reference

12 December 2020

Comparative analysis of six European influenza vaccines

1 reference

12 December 2020

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

1 reference

12 December 2020

Clinical validation of the "in silico" prediction of immunogenicity of a human recombinant therapeutic protein.

1 reference

12 December 2020

Pegylation: a novel process for modifying pharmacokinetics

1 reference

12 December 2020

Humanised monoclonal antibody therapy for rheumatoid arthritis

1 reference

12 December 2020

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

1 reference

12 December 2020

A review of Campath in autoimmune disease: biologic therapy in the gray zone between immunosuppression and immunoablation

1 reference

12 December 2020

Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis

1 reference

12 December 2020

Extended Rituximab (anti-CD20 monoclonal antibody) therapy for relapsed or refractory low-grade or follicular non-Hodgkin's lymphoma

1 reference

12 December 2020

The autoimmune pathogenesis of rheumatoid arthritis: role of autoreactive T cells and new immunotherapies

1 reference

12 December 2020

Decision making during the conception and career of CD4+ T cells.

1 reference

12 December 2020

Thyrotropin receptor epitopes and their relation to histocompatibility leukocyte antigen-DR molecules in Graves' disease

1 reference

12 December 2020

Long-term human coronavirus-myelin cross-reactive T-cell clones derived from multiple sclerosis patients

1 reference

12 December 2020

The danger model: a renewed sense of self

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12 December 2020

Autoimmune mechanisms in type 1 diabetes

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12 December 2020

Modelling the immunogenicity of therapeutic proteins using T cell epitope mapping

1 reference

12 December 2020

Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides

1 reference

12 December 2020

Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin

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12 December 2020

Targeting the development and effector functions of TH17 cells.

1 reference

12 December 2020

An interactive Web site providing major histocompatibility ligand predictions: application to HIV research

1 reference

12 December 2020

Computational methods for prediction of T-cell epitopes--a framework for modelling, testing, and applications

1 reference

12 December 2020

Immunomics: discovering new targets for vaccines and therapeutics

1 reference

12 December 2020

Clinical link between MHC class II haplotype and interferon-beta (IFN-beta) immunogenicity.

1 reference

12 December 2020

Antibodies and B cell memory in viral immunity

1 reference

12 December 2020

Identification and removal of a promiscuous CD4+ T cell epitope from the C1 domain of factor VIII.

1 reference

12 December 2020

The genetic basis of autoantibody production

1 reference

12 December 2020

Development of a maturing T-cell-mediated immune response in patients with idiopathic Parkinson's disease receiving r-metHuGDNF via continuous intraputaminal infusion

1 reference

12 December 2020

Balance of Th1 and Th17 effector and peripheral regulatory T cells

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12 December 2020

Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels

1 reference

12 December 2020

Recognition of hepatitis B surface antigen by human T lymphocytes. Proliferative and cytotoxic responses to a major antigenic determinant defined by synthetic peptides.

1 reference

12 December 2020

Epigenetic control of T-helper-cell differentiation

1 reference

12 December 2020

Identification of an epitope for T-cells correlated with antibody response to hepatitis B surface antigen in vaccinated humans

1 reference

12 December 2020

High-affinity binding of an influenza hemagglutinin-derived peptide to purified HLA-DR

1 reference

12 December 2020

Some factor VIII (FVIII) inhibitors recognise a FVIII epitope(s) that is present only on FVIII-vWF complexes

1 reference

12 December 2020

Low avidity recognition of self-antigen by T cells permits escape from central tolerance.

1 reference

12 December 2020

Treatment of therapy-refractory B-lineage acute lymphoblastic leukemia with an apoptosis-inducing CD19-directed tyrosine kinase inhibitor

1 reference

12 December 2020

CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes

1 reference

12 December 2020

Immuno-informatics: Mining genomes for vaccine components

1 reference

12 December 2020

Use of site-directed mutagenesis to enhance the epitope-shielding effect of covalent modification of proteins with polyethylene glycol

1 reference

12 December 2020

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

1 reference

12 December 2020

Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection

1 reference

12 December 2020

Multiple sclerosis: a complicated picture of autoimmunity.

1 reference

12 December 2020

Clinical response to adalimumab: relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis

1 reference

12 December 2020

Immune responses to therapeutic proteins in humans--clinical significance, assessment and prediction

1 reference

12 December 2020

Rituximab treatment in patients with primary Sjögren's syndrome: an open-label phase II study

1 reference

12 December 2020

The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance

1 reference

12 December 2020

Prediction of HIV peptide epitopes by a novel algorithm.

1 reference

12 December 2020

A call to cellular & humoral arms: enlisting cognate T cell help to develop broad-spectrum vaccines against influenza A.

1 reference

12 December 2020

The expanding realm of heterologous immunity: friend or foe?

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12 December 2020

Human leukocyte antigens influence the immune response to a pre-S/S hepatitis B vaccine

1 reference

12 December 2020

A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice.

1 reference

12 December 2020

Naive and memory B cells in T-cell-dependent and T-independent responses

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12 December 2020

Nonresponse to hepatitis B vaccines and the kinetics of anti-HBs production

1 reference

12 December 2020

Rescue of the autoimmune scurfy mouse by partial bone marrow transplantation or by injection with T-enriched splenocytes

1 reference

12 December 2020

More than one reason to rethink the use of peptides in vaccine design

1 reference

12 December 2020

Diversity of Francisella tularensis Schu4 antigens recognized by T lymphocytes after natural infections in humans: Identification of candidate epitopes for inclusion in a rationally designed tularemia vaccine

1 reference

12 December 2020

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

1 reference

12 December 2020

An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais.

1 reference

12 December 2020

SAP is required for Th cell function and for immunity to influenza.

1 reference

12 December 2020

Confirmation of immunogenic consensus sequence HIV-1 T-cell epitopes in Bamako, Mali and Providence, Rhode Island

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12 December 2020

Several common HLA-DR types share largely overlapping peptide binding repertoires

1 reference

12 December 2020

HLA-A2-restricted CD8+-cytotoxic-T-cell responses to novel epitopes in Mycobacterium tuberculosis superoxide dismutase, alanine dehydrogenase, and glutamine synthetase

1 reference

12 December 2020

Safety and biodistribution of 99mTechnetium-labeled anti-CD44v6 monoclonal antibody BIWA 1 in head and neck cancer patients.

1 reference

12 December 2020

Prediction of immunogenicity for therapeutic proteins: state of the art.

1 reference

12 December 2020

DC activated via dectin-1 convert Treg into IL-17 producers

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12 December 2020

10.1016/J.ADDR.2009.07.001

Identifiers

DOI

1 reference

21 August 2017

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