Gene therapy for neurodegenerative diseases based on lentiviral vectors (Q37574419)

21 August 2017

1 reference

title

Gene therapy for neurodegenerative diseases based on lentiviral vectors (English)

1 reference

21 August 2017

0 references

0 references

1 reference

Aikaterini Nanou

1

1 reference

PubMed ID

19660657

21 August 2017

Mimoun Azzouz

series ordinal

2

1 reference

21 August 2017

1 January 2009

1 reference

Progress in Brain Research

21 August 2017

1 reference

21 August 2017

175

1 reference

21 August 2017

187-200

1 reference

Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout mice

21 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Lentivector-mediated SMN replacement in a mouse model of spinal muscular atrophy.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Neuroprotection in a rat Parkinson model by GDNF gene therapy using EIAV vector

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III)

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Parkinson's disease: a genetic perspective

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Levodopa-induced dyskinesia in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

The energetics of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Genetic mapping of chronic childhood-onset spinal muscular atrophy to chromosome 5q11.2-13.3

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Parkinson's disease: mechanisms and models

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Prospects for new restorative and neuroprotective treatments in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Neurotrophic factors and amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

A Drosophila model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Quantitative analyses of SMN1 and SMN2 based on real-time lightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Efficient in vivo protection of nigral dopaminergic neurons by lentiviral gene transfer of a modified Neurturin construct.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Striatal delivery of neurturin by CERE-120, an AAV2 vector for the treatment of dopaminergic neuron degeneration in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Mechanisms of neurodegeneration in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Local GDNF expression mediated by lentiviral vector protects facial nerve motoneurons but not spinal motoneurons in SOD1(G93A) transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

A mouse model for spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Development of a novel fusogenic viral liposome system (HVJ-liposomes) and its applications to the treatment of acquired diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Efficient gene transfer via retrograde transport in rodent and primate brains using a human immunodeficiency virus type 1-based vector pseudotyped with rabies virus glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Lentiviral gene transfer to the nonhuman primate brain

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Parkinson's disease. First of two parts

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Identification and characterization of a spinal muscular atrophy-determining gene

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Therapeutic benefits of cardiotrophin-1 gene transfer in a mouse model of spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Nonviral gene therapy: promises and challenges

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

A novel nuclear structure containing the survival of motor neurons protein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

SMN oligomerization defect correlates with spinal muscular atrophy severity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

A cellular model that recapitulates major pathogenic steps of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Gene for chronic proximal spinal muscular atrophies maps to chromosome 5q

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Transduction of motor neurons and muscle fibers by intramuscular injection of HIV-1-based vectors pseudotyped with select rabies virus glycoproteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

International SMA consortium meeting. (26-28 June 1992, Bonn, Germany)

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Plastin 3 is a protective modifier of autosomal recessive spinal muscular atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Intragenic telSMN mutations: frequency, distribution, evidence of a founder effect, and modification of the spinal muscular atrophy phenotype by cenSMN copy number.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Intrastriatal injections of quinolinic acid or kainic acid: differential patterns of cell survival and the effects of data analysis on outcome

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Erratum: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Spinal muscular atrophy: clinical classification and disease heterogeneity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Molecular and cellular pathways of neurodegeneration in motor neurone disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Alpha-synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Valproic acid increases SMN levels in spinal muscular atrophy patient cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

6-hydroxy-dopamine induced degeneration of central monoamine neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Neuropathology in mice expressing human alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

1 reference

7 January 2021

Animal models of Huntington's disease: implications in uncovering pathogenic mechanisms and developing therapies

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Motor neuron disease (amyotrophic lateral sclerosis).

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Transduction Patterns of Pseudotyped Lentiviral Vectors in the Nervous System

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Towards a transgenic model of Huntington's disease in a non-human primate

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

The Relationship between SMN, the Spinal Muscular Atrophy Protein, and Nuclear Coiled Bodies in Differentiated Tissues and Cultured Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

Glutamine repeats and neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2809%2917513-1

7 January 2021

10.1016/S0079-6123(09)17513-1

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

19660657