Structure-activity relationships of the glucuronidation of flavonoids by human glucuronosyltransferases. (Q37575653)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19663742%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

review article

1 reference

title

Structure-activity relationships of the glucuronidation of flavonoids by human glucuronosyltransferases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19663742%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19663742%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Ge Lin

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19663742%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

author name string

Li Zhang

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19663742%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Zhong Zuo

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19663742%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

language of work or name

English

0 references

publication date

1 November 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19663742%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Drug Metabolism & Toxicology

5 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19663742%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19663742%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19663742%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

page(s)

1399-1419

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19663742%20AND%20SRC:MED&resulttype=core&format=json

Anthocyanins and other flavonoids.

5 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Flavonoids, vascular function and cardiovascular protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Recent advance in the research of flavonoids as anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Pharmacokinetics and metabolism of dietary flavonoids in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Intestinal and hepatic glucuronidation of flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Glucuronidation versus oxidation of the flavonoid galangin by human liver microsomes and hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Structural and functional studies of UDP-glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

SAR and QSAR of the antioxidant activity of flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

A quantitative structure-activity relationship model for radical scavenging activity of flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

QSAR aspects of flavonoids as a plentiful source of new drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

The relation between the chemical structure of flavonoids and their estrogen-like activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Comparison of enzymically glucuronidated flavonoids with flavonoid aglycones in an in vitro cellular model of oxidative stress protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Genistein- and daidzein 7-O-beta-D-glucuronic acid retain the ability to inhibit copper-mediated lipid oxidation of low density lipoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Glucuronides of tea catechins: enzymology of biosynthesis and biological activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

In vitro biological properties of flavonoid conjugates found in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Onions: a source of unique dietary flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Properties of quercetin conjugates: modulation of LDL oxidation and binding to human serum albumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Quercetin glucuronide inhibits cell migration and proliferation by platelet-derived growth factor in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Flavonoid glucuronides are substrates for human liver beta-glucuronidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Effect of quercetin conjugates on vascular permeability and expression of adhesion molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Biotransformation of green tea polyphenols and the biological activities of those metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Pharmacophore and quantitative structure activity relationship modelling of UDP-glucuronosyltransferase 1A1 (UGT1A1) substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Syntheses of daidzein-7-yl beta-D-glucopyranosiduronic acid and daidzein-4',7-yl di-beta-D-glucopyranosiduronic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Substrate specificity of plant UDP-dependent glycosyltransferases predicted from crystal structures and homology modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

A historical overview of the heterologous expression of mammalian UDP-glucuronosyltransferase isoforms over the past twenty years.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Involvement of UDP-glucuronosyltransferases in the extensive liver and intestinal first-pass metabolism of flavonoid baicalein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Glucuronidation of flavonoids by recombinant UGT1A3 and UGT1A9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Phase I study of flavopiridol in combination with Paclitaxel and Carboplatin in patients with non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

A phase II study of flavopiridol (Alvocidib) in combination with docetaxel in refractory, metastatic pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

In vitro characterization of hepatic flavopiridol metabolism using human liver microsomes and recombinant UGT enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Differential and Special Properties of the Major Human UGT1-encoded Gastrointestinal UDP-glucuronosyltransferases Enhance Potential to Control Chemical Uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Glucuronidation of bioflavonoids by human UGT1A10: structure-function relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Disposition of flavonoids via enteric recycling: determination of the UDP-glucuronosyltransferase isoforms responsible for the metabolism of flavonoids in intact Caco-2 TC7 cells using siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

UDP-Glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Glucuronidation Activity of the UGT2B17 Enzyme toward Xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

The configuration of the 17-hydroxy group variably influences the glucuronidation of beta-estradiol and epiestradiol by human UDP-glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Human UDP-glucuronosyltransferase 1A5: identification, expression, and activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Isolation and characterization of a human orphan UDP-glucuronosyltransferase, UGT2B11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Quantitative regioselectivity of glucuronidation of quercetin by recombinant UDP-glucuronosyltransferases 1A9 and 1A3 using enzymatic kinetic parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Regioselectivity of human UDP-glucuronosyl-transferase 1A1 in the synthesis of flavonoid glucuronides determined by metal complexation and tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Absorption and metabolism of genistein and its five isoflavone analogs in the human intestinal Caco-2 model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Plasma profiling of intact isoflavone metabolites by high-performance liquid chromatography and mass spectrometric identification of flavone glycosides daidzin and genistin in human plasma after administration of kinako

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Glucuronidation of the soyabean isoflavones genistein and daidzein by human liver is related to levels of UGT1A1 and UGT1A9 activity and alters isoflavone response in the MCF-7 human breast cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

The importance of local chemical structure for chemical metabolism by human uridine 5'-diphosphate-glucuronosyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Intestinal first-pass glucuronidation activities of selected dihydroxyflavones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Anthocyanins: structural characteristics that result in unique metabolic patterns and biological activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Disposition and metabolism of the flavonoid chrysin in normal volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Disposition of flavonoids via enteric recycling: structural effects and lack of correlations between in vitro and in situ metabolic properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Structures of (-)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (-)-epicatechin: differences between human and rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

In vitro metabolism of eupatilin by multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Quantitative structure activity relationships in drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Towards integrated ADME prediction: past, present and future directions for modelling metabolism by UDP-glucuronosyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Quantitative structure activity relationships for the glucuronidation of simple phenols by expressed human UGT1A6 and UGT1A9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Recent advances in the in silico modelling of UDP glucuronosyltransferase substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Predicting human drug glucuronidation parameters: application of in vitro and in silico modeling approaches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Glucuronidation and sulfation of the tea flavonoid (-)-epicatechin by the human and rat enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Absorption, Conjugation and Efflux of the Flavonoids, Kaempferol and Galangin, Using the Intestinal CACO-2/TC7 Cell Model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Pharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Stereospecific high-performance liquid chromatographic analysis of hesperetin in biological matrices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Stereospecific high-performance liquid chromatographic analysis of naringenin in urine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Stereospecific high-performance liquid chromatography of taxifolin, applications in pharmacokinetics, and determination in tu fu ling (Rhizoma smilacis glabrae) and apple (Malus x domestica).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Methods of analysis and separation of chiral flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Pharmacogenomics of human UDP-glucuronosyltransferase enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Cancer phytotherapeutics: role for flavonoids at the cellular level

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

The anti-cancer charm of flavonoids: a cup-of-tea will do!

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Lack of association between common polymorphisms in UGT1A9 and gene expression and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Developmental aspects of human hepatic drug glucuronidation in young children and adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Natural polyphenol disposition via coupled metabolic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Intra-herb pharmacokinetics interaction between quercetin and isorhamentin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Structure of UDP-glucuronosyltransferases in membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Regulation of UDP glucuronosyltransferases in the gastrointestinal tract.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

In vitro phase II metabolism of xanthohumol by human UDP-glucuronosyltransferases and sulfotransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Bioavailability and metabolism of orange juice flavanones in humans: impact of a full-fat yogurt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

Absorption, metabolism and excretion of flavanones from single portions of orange fruit and juice and effects of anthropometric variables and contraceptive pill use on flavanone excretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903179300

10.1517/17425250903179300

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19663742%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference