Function and regulation of Dyrk1A: towards understanding Down syndrome (Q37580743)

21 August 2017

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title

Function and regulation of Dyrk1A: towards understanding Down syndrome (English)

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21 August 2017

Joongkyu Park

1

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21 August 2017

Woo-Joo Song

series ordinal

2

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21 August 2017

Kwang Chul Chung

series ordinal

3

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21 August 2017

language of work or name

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14 August 2009

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Cellular and Molecular Life Sciences

21 August 2017

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21 August 2017

66

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21 August 2017

20

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21 August 2017

3235-3240

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https://scigraph.springernature.com/pub.10.1007/s00018-009-0123-2

21 August 2017

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Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation.

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Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated

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Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.

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The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development

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The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development.

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The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome

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QSAR analysis of pyrazolidine-3,5-diones derivatives as Dyrk1A inhibitors

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A mouse model for Down syndrome exhibits learning and behaviour deficits.

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Structural and functional characteristics of Dyrk, a novel subfamily of protein kinases with dual specificity.

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Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test.

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Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs

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Regulation of the proapoptotic activity of huntingtin interacting protein 1 by Dyrk1 and caspase-3 in hippocampal neuroprogenitor cells

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Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome

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Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

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DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease

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Truncation of the Down syndrome candidate gene DYRK1A in two unrelated patients with microcephaly

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Piracetam therapy does not enhance cognitive functioning in children with down syndrome

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The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease

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Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease

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A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells

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Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome.

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The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

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The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome

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Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome

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Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/- mouse

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Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

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Attenuation of Notch signalling by the Down-syndrome-associated kinase DYRK1A.

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Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships

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Down syndrome and Alzheimer disease: response to donepezil

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12 December 2020

Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.

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12 December 2020

Phosphorylation of Ser640 in Muscle Glycogen Synthase by DYRK Family Protein Kinases

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12 December 2020

Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII

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12 December 2020

The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4.

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12 December 2020

Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1.

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12 December 2020

Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice

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12 December 2020

A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region

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12 December 2020

Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome

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DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects.

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12 December 2020

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

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12 December 2020

DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassembly

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12 December 2020

The selectivity of protein kinase inhibitors: a further update

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12 December 2020

Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models

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12 December 2020

Down syndrome and the genes of human chromosome 21: current knowledge and future potentials

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12 December 2020

Putative therapeutic agents for the learning and memory deficits of people with Down syndrome.

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12 December 2020

DYRK1A is a novel negative regulator of cardiomyocyte hypertrophy

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12 December 2020

The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome

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12 December 2020

Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities

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12 December 2020

10.1007/S00018-009-0123-2

Identifiers

DOI

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21 August 2017

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