Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436). (Q37585155)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23833299%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

title

Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436) (English)

1 reference

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4 March 2020

0 references

1 reference

ChEBI release 2020-05-28

1 reference

Katherine L Nathanson

1

1 reference

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4 March 2020

Michael P. Brown

12

1 reference

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4 March 2020

Richard F. Kefford

19

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4 March 2020

Georgina V. Long

20

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4 March 2020

11

Michael Millward

1 reference

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4 March 2020

18

Peter F Lebowitz

1 reference

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4 March 2020

9

Gerald S Falchook

1 reference

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4 March 2020

8

Jeffrey R Infante

1 reference

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4 March 2020

13

Anna Pavlick

1 reference

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4 March 2020

author name string

Anne-Marie Martin

2

1 reference

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4 March 2020

Bradley Wubbenhorst

3

1 reference

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4 March 2020

Joel Greshock

4

1 reference

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4 March 2020

Richard Letrero

5

1 reference

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4 March 2020

Kurt D'Andrea

6

1 reference

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4 March 2020

Steven O'Day

7

1 reference

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4 March 2020

Hendrik-Tobias Arkenau

10

1 reference

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4 March 2020

Michael A Davies

14

1 reference

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4 March 2020

Bo Ma

15

1 reference

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4 March 2020

Robert Gagnon

16

1 reference

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4 March 2020

Martin Curtis

17

1 reference

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4 March 2020

language of work or name

English

0 references

publication date

5 July 2013

1 reference

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4 March 2020

published in

Clinical Cancer Research

1 reference

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4 March 2020

volume

19

1 reference

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4 March 2020

page(s)

4868-4878

1 reference

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4 March 2020

issue

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23833299%20AND%20SRC:MED&resulttype=core&format=json

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

4 March 2020

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Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial.

6 September 2017

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Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials

6 September 2017

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

6 September 2017

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Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance

6 September 2017

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Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

6 September 2017

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Identification of MET and SRC activation in melanoma cell lines showing primary resistance to PLX4032.

6 September 2017

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NRAS mutation status is an independent prognostic factor in metastatic melanoma

6 September 2017

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Role and therapeutic potential of PI3K-mTOR signaling in de novo resistance to BRAF inhibition

6 September 2017

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RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

6 September 2017

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Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF

6 September 2017

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Improved survival with vemurafenib in melanoma with BRAF V600E mutation

6 September 2017

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Copy number gains in 11q13 and 8q24 [corrected] are highly linked to prognosis in cutaneous malignant melanoma

6 September 2017

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Tumour evolution inferred by single-cell sequencing

6 September 2017

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Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling

6 September 2017

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PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression

6 September 2017

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6 September 2017

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Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K

6 September 2017

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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

6 September 2017

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

6 September 2017

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BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation

6 September 2017

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

6 September 2017

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A comprehensive catalogue of somatic mutations from a human cancer genome

6 September 2017

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Distinct patterns of DNA copy number alterations associate with BRAF mutations in melanomas and melanoma-derived cell lines

6 September 2017

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p16INK4a expression and absence of activated B-RAF are independent predictors of chemosensitivity in melanoma tumors

6 September 2017

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Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas

6 September 2017

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The MAPK pathway in melanoma

6 September 2017

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Distinct sets of genetic alterations in melanoma

6 September 2017

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PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma

6 September 2017

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Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

6 September 2017

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Germline p16 mutations in familial melanoma

6 September 2017

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Somatic alterations in the melanoma genome: a high-resolution array-based comparative genomic hybridization study

6 September 2017

1 reference

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Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.

14 September 2017

1 reference

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Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924894

Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924894

Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924894

Reduced p16 and increased cyclin D1 and pRb expression are correlated with progression in cutaneous melanocytic tumors.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924894

Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924894

PTEN expression in melanoma: relationship with patient survival, Bcl-2 expression, and proliferation.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924894

Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancers.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3924894

Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23833299

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Homogeneous staining regions for cyclin D1, a marker of poor prognosis in malignant melanoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23833299

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1078-0432.CCR-13-0827

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23833299%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23833299%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference