Senescence and life span (Q37599560)

21 August 2017

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title

Senescence and life span (English)

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21 August 2017

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Peter J Hornsby

1

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21 August 2017

8 September 2009

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21 August 2017

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21 August 2017

459

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21 August 2017

2

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21 August 2017

291-299

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https://scigraph.springernature.com/pub.10.1007/s00424-009-0723-6

21 August 2017

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cites work

Prevention of accelerated cell aging in Werner syndrome using a p38 mitogen-activated protein kinase inhibitor.

1 reference

https://api.crossref.org/works/10.1007%2FS00424-009-0723-6

Oncogenes and the DNA damage response: Myc and E2F1 engage the ATM signaling pathway to activate p53 and induce apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-009-0723-6

Cellular senescence and tissue aging in vivo

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-009-0723-6

p16INK4a as a second effector of the telomere damage pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-009-0723-6

The identification of zebrafish mutants showing alterations in senescence-associated biomarkers

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-009-0723-6

Ink4a/Arf expression is a biomarker of aging

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-009-0723-6

Bmi1, stem cells, and senescence regulation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-009-0723-6

p16INK4A participates in a G1 arrest checkpoint in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-009-0723-6

Brain inflammation and steroids: two double-edged swords.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-009-0723-6

Telomere dysfunction: multiple paths to the same end.

21 January 2018

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12 December 2020

DNA repair, genome stability, and aging

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12 December 2020

Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells

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12 December 2020

A role for CXCR2 in senescence, but what about in cancer?

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12 December 2020

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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12 December 2020

Senescence as a mode of tumor suppression

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12 December 2020

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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12 December 2020

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

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12 December 2020

Senescence, apoptosis and therapy--cutting the lifelines of cancer.

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12 December 2020

Total body irradiation selectively induces murine hematopoietic stem cell senescence

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12 December 2020

Hallmarks of senescence in carcinogenesis and cancer therapy

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12 December 2020

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

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12 December 2020

When cells get stressed: an integrative view of cellular senescence

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12 December 2020

Cellular senescence and organismal aging

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12 December 2020

Phosphorylated histone H2AX in spheroids, tumors, and tissues of mice exposed to etoposide and 3-amino-1,2,4-benzotriazine-1,3-dioxide

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12 December 2020

Human cell senescence as a DNA damage response.

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12 December 2020

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

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12 December 2020

Normal human fibroblasts are resistant to RAS-induced senescence

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12 December 2020

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

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12 December 2020

Restoration of p53 function leads to tumour regression in vivo

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12 December 2020

Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence

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12 December 2020

The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms.

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12 December 2020

Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging

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12 December 2020

Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging: what markers can we use?

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12 December 2020

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

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12 December 2020

Heterochromatin Focuses on Senescence

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12 December 2020

Essential role for oncogenic Ras in tumour maintenance

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12 December 2020

Senescence-associated beta-galactosidase is lysosomal beta-galactosidase

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12 December 2020

Exploration of replicative senescence-associated genes in human dermal fibroblasts by cDNA microarray technology

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12 December 2020

Senescence and immortalization: role of telomeres and telomerase

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12 December 2020

High frequency of BRAF mutations in nevi

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12 December 2020

Disappearance of the telomere dysfunction-induced stress response in fully senescent cells

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12 December 2020

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

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12 December 2020

Inflammation and cancer

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12 December 2020

ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

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12 December 2020

Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

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12 December 2020

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

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12 December 2020

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

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12 December 2020

Transient and reversible deoxyribonucleic acid damage in human left ventricle under controlled ischemia and reperfusion

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12 December 2020

Complicated tails: histone modifications and the DNA damage response

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12 December 2020

Cellular senescence: molecular mechanisms, in vivo significance, and redox considerations

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12 December 2020

Replicative senescence: implications for in vivo aging and tumor suppression

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12 December 2020

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

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12 December 2020

From the Hayflick mosaic to the mosaics of ageing. Role of stress-induced premature senescence in human ageing

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12 December 2020

E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts.

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12 December 2020

Inflammatory signaling and cellular senescence

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12 December 2020

High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human Fibroblasts

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12 December 2020

The cellular response to DNA double-strand breaks: defining the sensors and mediators

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12 December 2020

Chromatin in need of a fix: phosphorylation of H2AX connects chromatin to DNA repair

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12 December 2020

Cellular senescence in cancer treatment: friend or foe?

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12 December 2020

Expression and radiation-induced phosphorylation of histone H2AX in mammalian cells

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12 December 2020

The power and the promise of oncogene-induced senescence markers.

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12 December 2020

Oncogene-induced cell senescence--halting on the road to cancer

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12 December 2020

Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts

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12 December 2020

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

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12 December 2020

Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion

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12 December 2020

DNA damage response and cellular senescence in tissues of aging mice

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12 December 2020

Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo.

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12 December 2020

Characteristics of gamma-H2AX foci at DNA double-strand breaks sites

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12 December 2020

Senescence as an anticancer mechanism

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12 December 2020

Ras induces chromosome instability and abrogation of the DNA damage response.

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12 December 2020

Telomerase: Dr Jekyll or Mr Hyde?

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12 December 2020

DNA double-strand breaks and gamma-H2AX signaling in the testis

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12 December 2020

Tumor cell senescence in cancer treatment

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12 December 2020

Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells

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12 December 2020

Ink4a/Arf links senescence and aging

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12 December 2020

Senescence-messaging secretome: SMS-ing cellular stress

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12 December 2020

Autophagy mediates the mitotic senescence transition

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12 December 2020

Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity

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12 December 2020

Senescence of activated stellate cells limits liver fibrosis

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12 December 2020

Cellular senescence in aging primates.

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12 December 2020

Accumulation of senescent cells in mitotic tissue of aging primates

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12 December 2020

Cellular senescence: hot or what?

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12 December 2020

Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model.

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12 December 2020

Microarray analysis of replicative senescence

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12 December 2020

BRAFE600-associated senescence-like cell cycle arrest of human naevi

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12 December 2020

Fibroblast stimulation of blood vessel development and cancer cell invasion in a subrenal capsule xenograft model: stress-induced premature senescence does not increase effect

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12 December 2020

10.1007/S00424-009-0723-6

Identifiers

DOI

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21 August 2017

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PubMed ID

19763609