DNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new therapeutic targets. (Q37602208)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19775280%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

review article

1 reference

title

DNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new therapeutic targets (English)

1 reference

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8 February 2020

0 references

1 reference

1 reference

2

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8 February 2020

author name string

Long Shan Li

1

1 reference

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8 February 2020

Martina Veigl

3

1 reference

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8 February 2020

David Sedwick

4

1 reference

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8 February 2020

Sheldon Greer

5

1 reference

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8 February 2020

Mark Meyers

6

1 reference

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8 February 2020

Mark Wagner

7

1 reference

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8 February 2020

Richard Fishel

8

1 reference

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8 February 2020

David A Boothman

9

1 reference

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8 February 2020

language of work or name

English

0 references

publication date

23 September 2009

1 reference

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British Journal of Pharmacology

8 February 2020

published in

1 reference

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8 February 2020

volume

158

1 reference

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8 February 2020

issue

3

1 reference

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8 February 2020

page(s)

679-692

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Sequence context effect for hMSH2-hMSH6 mismatch-dependent activation

8 February 2020

cites work

1 reference

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Coupling distant sites in DNA during DNA mismatch repair.

23 August 2017

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Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair

23 August 2017

1 reference

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Structure of the human MutSalpha DNA lesion recognition complex

23 August 2017

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ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts

23 August 2017

1 reference

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Mismatch repair status in the prediction of benefit from adjuvant fluorouracil chemotherapy in colorectal cancer

23 August 2017

1 reference

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Reconstitution of 5'-directed human mismatch repair in a purified system

23 August 2017

1 reference

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Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility

23 August 2017

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An Msh2 point mutation uncouples DNA mismatch repair and apoptosis

23 August 2017

1 reference

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Mechanism of 5'-directed excision in human mismatch repair

23 August 2017

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A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage.

23 August 2017

1 reference

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Chromosomal imbalances in the colorectal carcinomas with microsatellite instability

23 August 2017

1 reference

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Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates

23 August 2017

1 reference

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Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer

23 August 2017

1 reference

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Uracil in DNA--occurrence, consequences and repair

23 August 2017

1 reference

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Mismatch repair defects as a cause of resistance to cytotoxic drugs

23 August 2017

1 reference

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Activation of human MutS homologs by 8-oxo-guanine DNA damage

23 August 2017

1 reference

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The selection for mismatch repair defects in hereditary nonpolyposis colorectal cancer: revising the mutator hypothesis.

23 August 2017

1 reference

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The interaction of DNA mismatch repair proteins with human exonuclease I

23 August 2017

1 reference

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Molecular predictors of survival after adjuvant chemotherapy for colon cancer

23 August 2017

1 reference

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Role of MED1 (MBD4) Gene in DNA repair and human cancer

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch

23 August 2017

1 reference

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Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA

23 August 2017

1 reference

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Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase

23 August 2017

1 reference

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Base excision repair of DNA in mammalian cells

23 August 2017

1 reference

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The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch

23 August 2017

1 reference

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Involvement of bcl-2 and p21waf1 proteins in response of human breast cancer cell clones to Tomudex

23 August 2017

1 reference

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Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

23 August 2017

1 reference

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The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

23 August 2017

1 reference

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Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair

23 August 2017

1 reference

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MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1

23 August 2017

1 reference

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hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA

23 August 2017

1 reference

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The interaction of the human MutL homologues in hereditary nonpolyposis colon cancer

23 August 2017

1 reference

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Human exonuclease I interacts with the mismatch repair protein hMSH2

23 August 2017

1 reference

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Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer

23 August 2017

1 reference

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Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha

23 August 2017

1 reference

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Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.

23 August 2017

1 reference

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Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase

23 August 2017

1 reference

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Structural basis for MutH activation in E.coli mismatch repair and relationship of MutH to restriction endonucleases

23 August 2017

1 reference

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The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch

23 August 2017

1 reference

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MutS mediates heteroduplex loop formation by a translocation mechanism

23 August 2017

1 reference

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G protein mechanisms: insights from structural analysis

23 August 2017

1 reference

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Cell cycle regulation of the human DNA mismatch repair genes hMSH2, hMLH1, and hPMS2.

23 August 2017

1 reference

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hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

23 August 2017

1 reference

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Mismatch repair in replication fidelity, genetic recombination, and cancer biology

23 August 2017

1 reference

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hMutSbeta, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA

23 August 2017

1 reference

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Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs

23 August 2017

1 reference

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Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

23 August 2017

1 reference

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Improving the anti-tumor activity of 5-fluorouracil by increasing its incorporation into RNA via metabolic modulation

23 August 2017

1 reference

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Deoxyribonucleotide pools, base pairing, and sequence configuration affecting bromodeoxyuridine- and 2-aminopurine-induced mutagenesis

23 August 2017

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Methyl-directed repair of DNA base-pair mismatches in vitro

23 August 2017

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Multienzyme complex for metabolic channeling in mammalian DNA replication

23 August 2017

1 reference

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Requirement for d(GATC) sequences in Escherichia coli mutHLS mismatch correction

23 August 2017

1 reference

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DNA mismatch repair detected in human cell extracts

23 August 2017

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Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs

23 August 2017

1 reference

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DNA mismatch correction in a defined system

23 August 2017

1 reference

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Protective, tumor-selective dual pathway activation of 5-fluoro-2'-deoxycytidine provided by tetrahydrouridine in mice bearing mammary adenocarcinoma-755

23 August 2017

1 reference

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Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines

23 August 2017

1 reference

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Participation of p53 protein in the cellular response to DNA damage

23 August 2017

1 reference

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Mechanisms and biological effects of mismatch repair

23 August 2017

1 reference

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Metabolism and mechanism of action of 5-fluorouracil

23 August 2017

1 reference

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Altering the conserved nucleotide binding motif in the Salmonella typhimurium MutS mismatch repair protein affects both its ATPase and mismatch binding activities

23 August 2017

1 reference

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Mechanism of human methyl-directed DNA methyltransferase and the fidelity of cytosine methylation

23 August 2017

1 reference

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Repair of DNA heteroduplexes containing small heterologous sequences in Escherichia coli

23 August 2017

1 reference

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Mismatch repair in heteroduplex DNA

23 August 2017

1 reference

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Repair tracts in mismatched DNA heteroduplexes

23 August 2017

1 reference

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Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer

23 August 2017

1 reference

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Dominant Saccharomyces cerevisiae msh6 mutations cause increased mispair binding and decreased dissociation from mispairs by Msh2-Msh6 in the presence of ATP.

6 September 2017

1 reference

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The effect of O6-methylguanine DNA adducts on the adenosine nucleotide switch functions of hMSH2-hMSH6 and hMSH2-hMSH3.

6 September 2017

1 reference

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DNA-dependent activation of the hMutSalpha ATPase

6 September 2017

1 reference

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MutS and MutL activate DNA helicase II in a mismatch-dependent manner

6 September 2017

1 reference

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Bidirectional excision in methyl-directed mismatch repair

6 September 2017

1 reference

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Methyl-directed mismatch repair is bidirectional

6 September 2017

1 reference

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Exploitation of elevated pyrimidine deaminating enzymes for selective chemotherapy.

6 September 2017

1 reference

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Methyl-directed DNA mismatch correction.

6 September 2017

1 reference

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Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectively

6 September 2017

1 reference

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Role of c-Abl kinase in DNA mismatch repair-dependent G2 cell cycle checkpoint arrest responses.

14 September 2017

1 reference

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Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Perspective on the design and biochemical pharmacology of inhibitors of thymidylate synthetase

14 September 2017

1 reference

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Fluorinated pyrimidines and their nucleosides

14 September 2017

1 reference

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Mutation induction by 5-fluorodeoxyuridine in synchronous Chinese hamster cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

DNA mismatch repair-dependent activation of c-Abl/p73alpha/GADD45alpha-mediated apoptosis.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Apoptosis induced by overexpression of hMSH2 or hMLH1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Comparison of 5-fluoro-2'-deoxyuridine with 5-fluorouracil and their role in the treatment of colorectal cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Bromouracil mutagenesis and mismatch repair in mutator strains of Escherichia coli

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Fluorouracil in colorectal cancer--a tale of two drugs: implications for biochemical modulation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Single-strand DNA-specific exonucleases in Escherichia coli. Roles in repair and mutation avoidance.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Strand-specific mismatch repair in mammalian cells

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Coupled ribonucleoside diphosphate reduction, channeling, and incorporation into DNA of mammalian cells

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Use of 5-fluorodeoxycytidine and tetrahydrouridine to exploit high levels of deoxycytidylate deaminase in tumors to achieve DNA- and target-directed therapies

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

5-fluorouracil modulation of dihydrofolate reductase RNA levels in methotrexate-resistant KB cells

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

DNA methylation controls the inducibility of the mouse metallothionein-I gene in lymphoid cells

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Effects of 5-fluorouracil on dihydrofolate reductase and dihydrofolate reductase mRNA from methotrexate-resistant KB cells

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Mismatch repair of cis-diamminedichloroplatinum(II)-induced DNA damage.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Escherichia coli helicase II (urvD gene product) translocates unidirectionally in a 3' to 5' direction

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Isolation and characterization of the Escherichia coli mutH gene product.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Isolation and characterization of the Escherichia coli mutL gene product.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Endonucleolytic function of MutLalpha in human mismatch repair.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Mismatch repair proteins as sensors of alkylation DNA damage

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

The coordinated functions of the E. coli MutS and MutL proteins in mismatch repair

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

HNPCC mutations in hMSH2 result in reduced hMSH2-hMSH6 molecular switch functions

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Mechanisms of tolerance to DNA damaging therapeutic drugs

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Mismatch repair, molecular switches, and signal transduction

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2765589

Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy

1 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00423.X

Mismatch correction at O 6 -methylguanine residues in E. coli DNA

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2009.00423.X

Heat-induced deamination of cytosine residues in deoxyribonucleic acid

21 January 2018

1 reference

12 December 2020

Potentiation of the anti-tumor activity of 5FU by thymidine and its correlation with the formation of (5FU)RNA

1 reference

12 December 2020

Mechanism for exclusion of 5-fluorouracil from DNA

1 reference

12 December 2020

Cytotoxic mechanisms of 5-fluoropyrimidines. Relationships with poly(ADP-ribose) polymerase activity, DNA strand breakage and incorporation into nucleic acids

1 reference

12 December 2020

New mechanism of action of the cancer chemotherapeutic agent 5-fluorouracil in human cells

1 reference

12 December 2020

1 reference

12 December 2020

Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation

1 reference

12 December 2020

Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model

1 reference

12 December 2020

p53 gene mutation, microsatellite instability and adjuvant chemotherapy: impact on survival of 388 patients with Dukes' C colon carcinoma

1 reference

12 December 2020

The role of deoxyuridine triphosphate nucleotidohydrolase, uracil-DNA glycosylase, and DNA polymerase alpha in the metabolism of FUdR in human tumor cells

1 reference

12 December 2020

Mutagen-induced changes in cellular deoxycytidine triphosphate and thymidine triphosphate in Chinese hamster ovary cells

1 reference

12 December 2020

Rapid changes in deoxynucleoside triphosphate pools in mammalian cells treated with mutagens

1 reference

12 December 2020

Metabolic channeling of 5-fluoro-2'-deoxycytidine utilizing inhibitors of its deamination in cell culture

1 reference

12 December 2020

Gene conversion in Escherichia coli. Resolution of heteroallelic mismatched nucleotides by co-repair

1 reference

12 December 2020

Tumor-selective metabolism of 5-fluoro-2'-deoxycytidine coadministered with tetrahydrouridine compared to 5-fluorouracil in mice bearing Lewis lung carcinoma

1 reference

12 December 2020

Heteroduplex repair in extracts of human HeLa cells

1 reference

12 December 2020

Relationship of in vivo antitumor activities of fluorinated pyrimidines to thymidylate synthase activity and intratumoral concentrations of 5-fluorouracil and uracil

1 reference

12 December 2020

Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex

1 reference

12 December 2020

Dissociation of mismatch recognition and ATPase activity by hMSH2-hMSH3

1 reference

12 December 2020

Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice

1 reference

12 December 2020

Signaling mismatch repair in cancer

1 reference

12 December 2020

10.1111/J.1476-5381.2009.00423.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19775280%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19775280%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

19775280

1 reference