Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2. (Q37605156)

21 August 2017

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title

Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2. (English)

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21 August 2017

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Nadja Bitomsky

1

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PubMed ID

19788416

21 August 2017

Thomas G Hofmann

series ordinal

2

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PubMed ID

19788416

21 August 2017

language of work or name

English

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publication date

29 September 2009

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21 August 2017

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21 August 2017

276

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21 August 2017

6074-6083

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21 August 2017

21

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The DNA damage response: ten years after

21 August 2017

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

DNA damage signalling guards against activated oncogenes and tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

The many substrates and functions of ATM

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

21 January 2018

How cells activate ATR.

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

ATM regulates ATR chromatin loading in response to DNA double-strand breaks

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Interfaces between the detection, signaling, and repair of DNA damage

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Live or let die: the cell's response to p53

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

p53 ubiquitination: Mdm2 and beyond

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Post-translational modification of p53 in tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Atmospheric carbon dioxide concentrations over the past 60 million years

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

The function of PML in p53-dependent apoptosis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Body language: the function of PML nuclear bodies in apoptosis regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Role of nuclear bodies in apoptosis signalling

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

How cells switch HIPK2 on and off

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

PML is a direct p53 target that modulates p53 effector functions

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Oncogene-dependent regulation of caspase activation by p53 protein in a cell-free system

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

p53 has a direct apoptogenic role at the mitochondria

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

The post-translational phosphorylation and acetylation modification profile is not the determining factor in targeting endogenous stress-induced p53 to mitochondria

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Monoubiquitylation promotes mitochondrial p53 translocation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

MSL2 promotes Mdm2-independent cytoplasmic localization of p53

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Regulation of autophagy by cytoplasmic p53

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Self-eating and self-killing: crosstalk between autophagy and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

p73, the "assistant" guardian of the genome?

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

The ubiquitin-protein ligase Itch regulates p73 stability

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

p73-induced apoptosis: a question of compartments and cooperation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Interaction between ATM protein and c-Abl in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

P73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

c-Jun NH2-terminal kinase promotes apoptosis by down-regulating the transcriptional co-repressor CtBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

TGFbeta1-induced activation of ATM and p53 mediates apoptosis in a Smad7-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07331.X

10.1111/J.1742-4658.2009.07331.X

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

19788416