Polycomb group protein gene silencing, non-coding RNA, stem cells, and cancer (Q37629613)

21 August 2017

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title

Polycomb group protein gene silencing, non-coding RNA, stem cells, and cancer (English)

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21 August 2017

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Randall S Gieni

1

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PubMed ID

19898523

21 August 2017

Michael J Hendzel

series ordinal

2

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21 August 2017

1 October 2009

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Biochemistry and Cell Biology

21 August 2017

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21 August 2017

87

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21 August 2017

5

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21 August 2017

711-746

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Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1

21 August 2017

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Cancer stem cells in solid tumors

21 January 2018

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Prospective identification of tumorigenic breast cancer cells

21 January 2018

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Increased expression of EZH2, a polycomb group protein, in bladder carcinoma

21 January 2018

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Independent prognostic value of the basal-like phenotype of breast cancer and associations with EGFR and candidate stem cell marker BMI-1.

21 January 2018

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Chromatin signatures of pluripotent cell lines

21 January 2018

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Mutation screen and association study of EZH2 as a susceptibility gene for aggressive prostate cancer.

21 January 2018

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EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast

21 January 2018

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Loss of BMI-1 expression is associated with clinical progress of malignant melanoma.

21 January 2018

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The impact of microRNAs on protein output

21 January 2018

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Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype

21 January 2018

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MicroRNAs: genomics, biogenesis, mechanism, and function

21 January 2018

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Polycomb group protein Bmi1 is required for growth of RAF driven non-small-cell lung cancer

21 January 2018

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The Wnt connection to tumorigenesis

21 January 2018

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Temozolomide preferentially depletes cancer stem cells in glioblastoma

21 January 2018

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CD133 expression and cancer stem cells predict prognosis in high-grade oligodendroglial tumors.

21 January 2018

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The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2.

21 January 2018

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Reprogramming epigenetic silencing: artificial transcription factors synergize with chromatin remodeling drugs to reactivate the tumor suppressor mammary serine protease inhibitor.

21 January 2018

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An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors

21 January 2018

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Structural-proliferative units and organ growth: effects of insulin-like growth factor 2 on the growth of colon and skin.

21 January 2018

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CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus.

21 January 2018

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21 January 2018

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

21 January 2018

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Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin

21 January 2018

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Global identification of human transcribed sequences with genome tiling arrays

21 January 2018

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BMI-1 expression is enhanced through transcriptional and posttranscriptional regulation during the progression of chronic myeloid leukemia

21 January 2018

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Variation, "evolution", immortality and genetic instabilities in tumour cells

21 January 2018

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Anticancer activities of histone deacetylase inhibitors

21 January 2018

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Cancer stem cells: a step toward the cure.

21 January 2018

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Polycomb complexes repress developmental regulators in murine embryonic stem cells

21 January 2018

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EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

21 January 2018

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Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

21 January 2018

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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

21 January 2018

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Biology of polycomb and trithorax group proteins

21 January 2018

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Increased expression of the EZH2 polycomb group gene in BMI-1-positive neoplastic cells during bronchial carcinogenesis.

21 January 2018

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EZH2 promotes proliferation and invasiveness of prostate cancer cells

21 January 2018

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Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression

21 January 2018

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let-7 microRNAs in development, stem cells and cancer

21 January 2018

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Expression of secreted Wnt antagonists in gastrointestinal tissues: potential role in stem cell homeostasis

21 January 2018

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Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

21 January 2018

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A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia

21 January 2018

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Cancer genes hypermethylated in human embryonic stem cells

21 January 2018

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Altered HOX and WNT7A expression in human lung cancer

21 January 2018

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SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex

21 January 2018

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The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.

21 January 2018

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Role of histone H3 lysine 27 methylation in Polycomb-group silencing

21 January 2018

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Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing

21 January 2018

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Repression of E-cadherin by the polycomb group protein EZH2 in cancer

21 January 2018

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Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapy

21 January 2018

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The transcriptional landscape of the mammalian genome

21 January 2018

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Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3

21 January 2018

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Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency

21 January 2018

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MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells

21 January 2018

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Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases

21 January 2018

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A microRNA as a translational repressor of APETALA2 in Arabidopsis flower development

21 January 2018

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Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution

21 January 2018

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Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.

21 January 2018

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Epigenetics and microRNAs

21 January 2018

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Extensive modulation of a set of microRNAs in primary glioblastoma

21 January 2018

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miR-15 and miR-16 induce apoptosis by targeting BCL2

21 January 2018

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Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer

21 January 2018

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Chromatin, cancer and drug therapies

21 January 2018

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Non-coding RNAs: new players in eukaryotic biology

21 January 2018

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H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment

21 January 2018

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The polycomb group protein enhancer of zeste homolog 2 (EZH 2) is an oncogene that influences myeloma cell growth and the mutant ras phenotype

21 January 2018

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Loss of imprinting of IGF2 as an epigenetic marker for the risk of human cancer

21 January 2018

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Bmi-1 regulates the differentiation and clonogenic self-renewal of I-type neuroblastoma cells in a concentration-dependent manner.

21 January 2018

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Differential expression of the novel oncogene, SALL4, in lymphoma, plasma cell myeloma, and acute lymphoblastic leukemia

21 January 2018

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Bmi-1 is essential for the tumorigenicity of neuroblastoma cells

21 January 2018

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Common themes of dedifferentiation in somatic cell reprogramming and cancer

21 January 2018

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Chromatin remodeling agents for cancer therapy

21 January 2018

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Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation

21 January 2018

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Polycomb silencing blocks transcription initiation.

21 January 2018

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Enhancer of Zeste 2 as a marker of preneoplastic progression in the breast

21 January 2018

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NRED: a database of long noncoding RNA expression

21 January 2018

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Epigenetics: heterochromatin meets RNAi.

21 January 2018

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BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression

21 January 2018

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Do cells let-7 determine stemness?

21 January 2018

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Clinical development of histone deacetylase inhibitors as anticancer agents

21 January 2018

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Unique polycomb gene expression pattern in Hodgkin's lymphoma and Hodgkin's lymphoma-derived cell lines

21 January 2018

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Discovering motifs in ranked lists of DNA sequences

21 January 2018

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A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin

21 January 2018

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Low BMI-1 expression is associated with an activated BMI-1-driven signature, vascular invasion, and hormone receptor loss in endometrial carcinoma

21 January 2018

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New twists in X-chromosome inactivation.

21 January 2018

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Epigenetic gene silencing in cancer: the DNA hypermethylome

21 January 2018

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DNA methylation of RASSF1A, HIN‐1, RAR‐β, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma

21 January 2018

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Predicting aberrant CpG island methylation

21 January 2018

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Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb.

21 January 2018

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

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Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1

21 January 2018

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A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence

21 January 2018

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The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2.

21 January 2018

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Socializing with the neighbors: stem cells and their niche

21 January 2018

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Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines

21 January 2018

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Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer

21 January 2018

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Clusters of internally primed transcripts reveal novel long noncoding RNAs

21 January 2018

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Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

21 January 2018

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Cancer stem cells and therapeutic perspectives.

21 January 2018

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MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.

21 January 2018

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Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets

21 January 2018

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Polycomb CBX7 has a unifying role in cellular lifespan

21 January 2018

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Genomic models of metastatic cancer: functional analysis of death-from-cancer signature genes reveals aneuploid, anoikis-resistant, metastasis-enabling phenotype with altered cell cycle control and activated Polycomb Group (PcG) protein chromatin si

21 January 2018

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Stem cell origin of death-from-cancer phenotypes of human prostate and breast cancers

21 January 2018

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"Stemness" genomics law governs clinical behavior of human cancer: implications for decision making in disease management

21 January 2018

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Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer

21 January 2018

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Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal

21 January 2018

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The bmi-1 and mel-18 gene products define a new family of DNA-binding proteins involved in cell proliferation and tumorigenesis

21 January 2018

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Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer

21 January 2018

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The pathophysiology of HOX genes and their role in cancer.

21 January 2018

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21 January 2018

The microRNA Registry

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From genetics to epigenetics: the tale of Polycomb group and trithorax group genes

21 January 2018

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Cellular signaling in normal and cancerous stem cells

21 January 2018

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Epigenetic changes in cancer as potential targets for prophylaxis and maintenance therapy

21 January 2018

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Wnt signaling in renal cancer

21 January 2018

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Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins

21 January 2018

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Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells

21 January 2018

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Nuclear reprogramming in cells

21 January 2018

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MicroRNA miR-155 is a biomarker of early pancreatic neoplasia

21 January 2018

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Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers

21 January 2018

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Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cells

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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A model for transmission of the H3K27me3 epigenetic mark

21 January 2018

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A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation

21 January 2018

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Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours.

21 January 2018

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Beyond silencing--engineering applications of RNA interference and antisense technology for altering cellular phenotype

21 January 2018

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Cancerous stem cells can arise from pediatric brain tumors

21 January 2018

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MT1G hypermethylation is associated with higher tumor stage in prostate cancer

21 January 2018

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Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance.

21 January 2018

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21 January 2018

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Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer

21 January 2018

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CD44+ CD24(-) prostate cells are early cancer progenitor/stem cells that provide a model for patients with poor prognosis

21 January 2018

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EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor

21 January 2018

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Genomic imprinting mechanisms in mammals.

21 January 2018

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Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro

21 January 2018

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MicroRNA gene expression deregulation in human breast cancer

21 January 2018

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Dissecting self-renewal in stem cells with RNA interference

21 January 2018

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Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming

21 January 2018

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miRNA profiling for diagnosis and prognosis of human cancer

21 January 2018

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Loss of imprinting and cancer

21 January 2018

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The epigenetic magic of histone lysine methylation.

21 January 2018

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Translating the Histone Code

21 January 2018

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SET domain proteins modulate chromatin domains in eu- and heterochromatin.

21 January 2018

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A core Klf circuitry regulates self-renewal of embryonic stem cells.

21 January 2018

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RAS is regulated by the let-7 microRNA family

21 January 2018

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Stem cells primed for action: polycomb repressive complexes restrain the expression of lineage-specific regulators in embryonic stem cells.

21 January 2018

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Loss of imprinting of IGF2: a common epigenetic modifier of intestinal tumor risk

21 January 2018

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X chromosome inactivation in the absence of Dicer.

21 January 2018

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Elevated Bmi-1 expression is associated with dysplastic cell transformation during oral carcinogenesis and is required for cancer cell replication and survival

21 January 2018

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Epigenetic regulator polycomb group protein complexes control cell fate and cancer

21 January 2018

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Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays

21 January 2018

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SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus

21 January 2018

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High expression of EZH2 is associated with tumor proliferation and prognosis in human oral squamous cell carcinomas

21 January 2018

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The regulation of INK4/ARF in cancer and aging

21 January 2018

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Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells

21 January 2018

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MicroRNA-directed transcriptional gene silencing in mammalian cells

21 January 2018

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EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

21 January 2018

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Genomic DNA methylation: the mark and its mediators

21 January 2018

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The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins

21 January 2018

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Identification of target antigens in specific immunotherapy for renal cell carcinoma

21 January 2018

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Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas.

21 January 2018

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Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

21 January 2018

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pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.

21 January 2018

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Chromatin modifications and their function

21 January 2018

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BMI-1 expression is inversely correlated with the grading of renal clear cell carcinoma

21 January 2018

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Silencing of microRNAs in vivo with 'antagomirs'

21 January 2018

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Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains

21 January 2018

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Current status of epigenetic treatment in myelodysplastic syndromes

21 January 2018

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Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3

21 January 2018

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Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation

21 January 2018

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Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres

21 January 2018

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Concise review: MicroRNA expression in multipotent mesenchymal stromal cells.

21 January 2018

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MicroRNA expression pattern of undifferentiated and differentiated human embryonic stem cells

21 January 2018

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A mammalian microRNA expression atlas based on small RNA library sequencing

21 January 2018

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21 January 2018

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Control of developmental regulators by Polycomb in human embryonic stem cells

21 January 2018

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Evolutionary conservation of microRNA regulatory circuits: an examination of microRNA gene complexity and conserved microRNA-target interactions through metazoan phylogeny

21 January 2018

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Mel-18 negatively regulates INK4a/ARF-independent cell cycle progression via Akt inactivation in breast cancer

21 January 2018

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Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis

21 January 2018

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Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer

21 January 2018

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

21 January 2018

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Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

21 January 2018

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A gene complex controlling segmentation in Drosophila

21 January 2018

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Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation.

21 January 2018

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Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex

21 January 2018

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Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages.

21 January 2018

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Loss of the human polycomb group protein BMI1 promotes cancer-specific cell death

21 January 2018

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Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells

21 January 2018

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Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer

21 January 2018

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The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

21 January 2018

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Evidence for the existence of an HP1-mediated subcode within the histone code.

21 January 2018

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MicroRNA expression profiles classify human cancers

21 January 2018

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Gene alterations identified by expression profiling in tumor-associated endothelial cells from invasive ovarian carcinoma

21 January 2018

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How epigenetics can explain human metastasis: a new role for microRNAs

21 January 2018

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Genetic unmasking of an epigenetically silenced microRNA in human cancer cells

21 January 2018

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A microRNA DNA methylation signature for human cancer metastasis

21 January 2018

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Polycomb complexes and silencing mechanisms.

21 January 2018

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DNA methyltransferase inhibitors and the development of epigenetic cancer therapies

21 January 2018

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The roles of microRNA in cancer and apoptosis

21 January 2018

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SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice

21 January 2018

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Genome imprinting regulated by the mouse Polycomb group protein Eed

21 January 2018

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Elongation of the Kcnq1ot1 transcript is required for genomic imprinting of neighboring genes

21 January 2018

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The epithelial-mesenchymal transition generates cells with properties of stem cells

21 January 2018

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Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms

21 January 2018

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Wnt signaling promotes reprogramming of somatic cells to pluripotency

21 January 2018

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Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells

21 January 2018

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A multifactorial signature of DNA sequence and polycomb binding predicts aberrant CpG island methylation

21 January 2018

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Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells

21 January 2018

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Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes

21 January 2018

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Differential expression of microRNAs in hematopoietic cell lineages

21 January 2018

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Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion

21 January 2018

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The role of DNA breaks in genomic instability and tumorigenesis

21 January 2018

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Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27

21 January 2018

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Liver stem cells and hepatocellular carcinoma

21 January 2018

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Architecture of a polycomb nucleoprotein complex

21 January 2018

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The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia.

21 January 2018

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Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

21 January 2018

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MicroRNA profiling of the murine hematopoietic system

21 January 2018

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Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential.

21 January 2018

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Role of RNA in the regulation of gene expression

21 January 2018

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Polycomb response elements and targeting of Polycomb group proteins in Drosophila.

21 January 2018

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Genomic instability: on the birth and death of cancer.

21 January 2018

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The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin

21 January 2018

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The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation

21 January 2018

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Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer

21 January 2018

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Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing

21 January 2018

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Small RNA regulators of gene expression.

21 January 2018

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Dynamic regulation of miRNA expression in ordered stages of cellular development.

21 January 2018

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BMI1 is a target gene of E2F-1 and is strongly expressed in primary neuroblastomas

21 January 2018

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Regulation of Hedgehog signaling: a complex story

21 January 2018

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A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

21 January 2018

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Generation of mouse induced pluripotent stem cells without viral vectors

21 January 2018

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Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways

21 January 2018

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Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer

21 January 2018

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

21 January 2018

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Reprogramming of human somatic cells to pluripotency with defined factors

21 January 2018

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The polycomb group protein Suz12 is required for embryonic stem cell differentiation

21 January 2018

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Silencing by imprinted noncoding RNAs: is transcription the answer?

21 January 2018

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Regulation of pluripotency and reprogramming by transcription factors

21 January 2018

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Protein interactions and complexes in human microRNA biogenesis and function

21 January 2018

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Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression

21 January 2018

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Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference

21 January 2018

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Stem cell regulation by polycomb repressors: postponing commitment

21 January 2018

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EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer

21 January 2018

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21 January 2018

Non coding RNA and brain

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Downregulation of BMI-1 enhances 5-fluorouracil-induced apoptosis in nasopharyngeal carcinoma cells

21 January 2018

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Coexpression of BMI-1 and EZH2 polycomb group genes in Reed-Sternberg cells of Hodgkin's disease

21 January 2018

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Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene

21 January 2018

1 reference

Histone H3 lysine 27 trimethylation in adult differentiated colon associated to cancer DNA hypermethylation

21 January 2018

1 reference

Concise review: roles of polycomb group proteins in development and disease: a stem cell perspective

21 January 2018

1 reference

Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder

21 January 2018

1 reference

Transcription through intergenic chromosomal memory elements of the Drosophila bithorax complex correlates with an epigenetic switch

21 January 2018

1 reference

The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing

21 January 2018

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Expression of BMI-1 in normal skin and inflammatory and neoplastic skin lesions.

21 January 2018

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Wnt signalling in stem cells and cancer

21 January 2018

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Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.

21 January 2018

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EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation

21 January 2018

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Polycomb, trithorax and the decision to differentiate

21 January 2018

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Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins

21 January 2018

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Polycomb/Trithorax response elements and epigenetic memory of cell identity

21 January 2018

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The transcriptional activity of human Chromosome 22

21 January 2018

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Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs

21 January 2018

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Bone marrow-derived cells fuse with normal and transformed intestinal stem cells

21 January 2018

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Wnt signaling and prostate cancer

21 January 2018

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Prognosis of breast cancer in carriers of BRCA1 and BRCA2 mutations

21 January 2018

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The let-7 family of microRNAs

21 January 2018

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Non-coding RNAs in imprinted gene clusters

21 January 2018

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Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells

21 January 2018

1 reference

Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor

21 January 2018

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Noncoding RNAs of trithorax response elements recruit Drosophila Ash1 to Ultrabithorax

21 January 2018

1 reference

MYC stimulates EZH2 expression by repression of its negative regulator miR-26a

21 January 2018

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Repressing the repressor: a new mode of MYC action in lymphomagenesis

21 January 2018

1 reference

The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer

21 January 2018

1 reference

Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis

21 January 2018

1 reference

The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma

21 January 2018

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A Drosophila Polycomb group complex includes Zeste and dTAFII proteins.

21 January 2018

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Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

21 January 2018

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Intergenic transcription through a polycomb group response element counteracts silencing

21 January 2018

1 reference

Genome regulation by polycomb and trithorax proteins

21 January 2018

1 reference

Polycomb silencing mechanisms and the management of genomic programmes

21 January 2018

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Polycomb silencing mechanisms in Drosophila.

21 January 2018

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Rapid alteration of microRNA levels by histone deacetylase inhibition

21 January 2018

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Role of the chromobox protein CBX7 in lymphomagenesis.

21 January 2018

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Noncoding RNA synthesis and loss of Polycomb group repression accompanies the colinear activation of the human HOXA cluster

21 January 2018

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Generation of a functional mammary gland from a single stem cell

21 January 2018

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Bmi1 in development and tumorigenesis of the central nervous system

21 January 2018

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MicroRNA-126 regulates HOXA9 by binding to the homeobox

21 January 2018

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EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

21 January 2018

1 reference

Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells.

21 January 2018

1 reference

Neural stem cell self-renewal

21 January 2018

1 reference

The ESC-E(Z) complex participates in the hedgehog signaling pathway

21 January 2018

1 reference

miR-21-mediated tumor growth

21 January 2018

1 reference

Circulating Bmi-1 mRNA as a possible prognostic factor for advanced breast cancer patients

21 January 2018

1 reference

Roles of the EZH2 histone methyltransferase in cancer epigenetics

21 January 2018

1 reference

Histone lysine methylation: a signature for chromatin function

21 January 2018

1 reference

Identification of human brain tumour initiating cells

21 January 2018

1 reference

The non-coding Air RNA is required for silencing autosomal imprinted genes

21 January 2018

1 reference

Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells

21 January 2018

1 reference

Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells

21 January 2018

1 reference

Polycomb silencers control cell fate, development and cancer

21 January 2018

1 reference

Suz12 binds to silenced regions of the genome in a cell-type-specific manner

21 January 2018

1 reference

Induced pluripotent stem cells generated without viral integration

21 January 2018

1 reference

The polycomb group proteins, BMI-1 and EZH2, are tumour-associated antigens

21 January 2018

1 reference

Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma

21 January 2018

1 reference

RNASEN regulates cell proliferation and affects survival in esophageal cancer patients

21 January 2018

1 reference

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

1 reference

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

21 January 2018

1 reference

Wnt signaling in liver cancer

21 January 2018

1 reference

Role of Polycomb-group genes in sustaining activities of normal and malignant stem cells

21 January 2018

1 reference

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

21 January 2018

1 reference

Hyperconserved CpG domains underlie Polycomb-binding sites

21 January 2018

1 reference

Dysregulated expression of stem cell factor Bmi1 in precancerous lesions of the gastrointestinal tract

21 January 2018

1 reference

Reprogramming of liver to pancreas.

21 January 2018

1 reference

A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells

21 January 2018

1 reference

PcG proteins, DNA methylation, and gene repression by chromatin looping.

21 January 2018

1 reference

Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer

21 January 2018

1 reference

Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.

21 January 2018

1 reference

Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes.

21 January 2018

1 reference

Stem cells and cancer; the polycomb connection

21 January 2018

1 reference

Expression of the polycomb-group gene BMI1 is related to an unfavourable prognosis in primary nodal DLBCL.

21 January 2018

1 reference

Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma.

21 January 2018

1 reference

The trithorax-group and polycomb-group chromatin modifiers: implications for disease

21 January 2018

1 reference

Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

21 January 2018

1 reference

The polycomb group protein EZH2 is involved in progression of prostate cancer

21 January 2018

1 reference

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer

21 January 2018

1 reference

High expression of Polycomb group protein EZH2 predicts poor survival in salivary gland adenoid cystic carcinoma.

21 January 2018

1 reference

De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase

21 January 2018

1 reference

The Polycomb group protein EZH2 directly controls DNA methylation

21 January 2018

1 reference

The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma

21 January 2018

1 reference

G9a histone methyltransferase contributes to imprinting in the mouse placenta

21 January 2018

1 reference

Role of histone H2A ubiquitination in Polycomb silencing

21 January 2018

1 reference

Hierarchical recruitment of polycomb group silencing complexes

21 January 2018

1 reference

Use of chromatin immunoprecipitation to clone novel E2F target promoters

21 January 2018

1 reference

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

21 January 2018

1 reference

Epigenetic stem cell signature in cancer

21 January 2018

1 reference

Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis

21 January 2018

1 reference

Module map of stem cell genes guides creation of epithelial cancer stem cells

21 January 2018

1 reference

Stemness, cancer and cancer stem cells

21 January 2018

1 reference

Partners in imprinting: noncoding RNA and polycomb group proteins.

21 January 2018

1 reference

Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing

21 January 2018

1 reference

21 January 2018

X inactivation Xplained

1 reference

MicroRNA control in the immune system: basic principles

21 January 2018

1 reference

Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells

21 January 2018

1 reference

Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells

21 January 2018

1 reference

SALL4 is a key regulator of survival and apoptosis in human leukemic cells

21 January 2018

1 reference

A skin microRNA promotes differentiation by repressing 'stemness'.

21 January 2018

1 reference

Epigenetic therapy of cancer: past, present and future

21 January 2018

1 reference

Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.

21 January 2018

1 reference

Identification of the human homolog of the imprinted mouse Air non-coding RNA.

21 January 2018

1 reference

let-7 regulates self renewal and tumorigenicity of breast cancer cells

21 January 2018

1 reference

Induced pluripotent stem cell lines derived from human somatic cells

21 January 2018

1 reference

Antisense RNA-mediated suppression of Bmi-1 gene expression inhibits the proliferation of lung cancer cell line A549.

21 January 2018

1 reference

Genomic profiling maps loss of heterozygosity and defines the timing and stage dependence of epigenetic and genetic events in Wilms' tumors.

21 January 2018

1 reference

Noncoding RNAs and gene silencing

21 January 2018

1 reference

The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells

21 January 2018

1 reference

Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer

21 January 2018

1 reference

Treatment of radioresistant stem-like esophageal cancer cells by an apoptotic gene-armed, telomerase-specific oncolytic adenovirus

21 January 2018

1 reference

Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer

21 January 2018

1 reference

Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome

21 January 2018

1 reference

Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells.

21 January 2018

1 reference

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells

21 January 2018

1 reference

MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1).

21 January 2018

1 reference

Comparative genome profiling across subtypes of low-grade B-cell lymphoma identifies type-specific and common aberrations that target genes with a role in B-cell neoplasia

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1139/O09-057

1 reference

21 August 2017

1 reference

PubMed ID

19898523