Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors. (Q37642614)

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2 April 2020

title

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors (English)

1 reference

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2 April 2020

0 references

1 reference

1 reference

5

1 reference

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2 April 2020

Christine Jandrasits

8

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2 April 2020

Vyacheslav Amstislavskiy

10

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Martin Lange

14

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James E Barrett

17

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Joseph Lewis Regan

25

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Ralf Herwig

30

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Ulf Landegren

31

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Stephan Beck

37

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Reinhold Schäfer

38

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Christian Regenbrecht

39

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Johannes Haybaeck

42

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Marie-Laure Yaspo

46

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Catherine Louise Worth

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Catherine L Worth

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45

Hans Lehrach

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15

Hans-Jörg Warnatz

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4

Karsten Boehnke

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6

Marlen Keil

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12

Caroline Schweiger

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Sandra Liebs

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Nicole Golob-Schwarzl

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26

Maxine Silvestrov

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36

Christoph Reinhard

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44

Jens Hoffmann

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author name string

Moritz Schütte

1

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Thomas Risch

2

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Nilofar Abdavi-Azar

3

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Reha Yildiriman

7

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Tatiana Borodina

9

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Lee M Butcher

16

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Marc Sultan

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Christoph Wierling

19

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Sigurd Lax

21

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Stefan Uranitsch

22

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Michael Becker

23

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Yvonne Welte

24

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Inge Kehler

27

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Alberto Fusi

28

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Thomas Kessler

29

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Dirk Wienke

32

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Mats Nilsson

33

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2 April 2020

Juan A Velasco

34

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Pilar Garin-Chesa

35

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2 April 2020

David Henderson

40

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2 April 2020

Bodo Lange

41

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2 April 2020

Ulrich Keilholz

43

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language of work or name

English

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publication date

10 February 2017

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2 April 2020

published in

Nature Communications

1 reference

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volume

8

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2 April 2020

page(s)

14262

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Creative Commons Attribution 4.0 International

2 April 2020

copyright license

start time

10 February 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1038/ncomms14262

0 references

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Metrics other than potency reveal systematic variation in responses to cancer drugs.

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23 August 2017

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Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status

23 August 2017

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23 August 2017

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23 August 2017

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An epigenetic signature in peripheral blood predicts active ovarian cancer

23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer

23 August 2017

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The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation

23 August 2017

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KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

23 August 2017

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Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas

23 August 2017

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Multiple SVM-RFE for gene selection in cancer classification with expression data

23 August 2017

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BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

23 August 2017

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Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts

23 August 2017

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A monkey antigen crossreacting with carcinoembryonic antigen, CEA

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

Prospective derivation of a living organoid biobank of colorectal cancer patients.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

Stromal contribution to the colorectal cancer transcriptome.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

REG4 acts as a mitogenic, motility and pro-invasive factor for colon cancer cells.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

Differential Crizotinib Response Duration Among ALK Fusion Variants in ALK-Positive Non-Small-Cell Lung Cancer.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

Pvclust: an R package for assessing the uncertainty in hierarchical clustering.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

Anticancer drug response and expression of molecular markers in early-passage xenotransplanted colon carcinomas.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

CLICK: a clustering algorithm with applications to gene expression analysis.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5309787

Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab

1 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS14262

inferred from DOI database lookup

7 January 2021

based on heuristic

Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS14262

inferred from DOI database lookup

7 January 2021

based on heuristic

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS14262

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCOMMS14262

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28186126%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28186126%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference