The PINK1/Parkin pathway: a mitochondrial quality control system? (Q37646370)

21 August 2017

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title

The PINK1/Parkin pathway: a mitochondrial quality control system? (English)

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21 August 2017

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Alexander J. Whitworth

object named as

Alexander J Whitworth

series ordinal

1

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author name string

Leo J Pallanck

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2

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21 August 2017

1 December 2009

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Journal of Bioenergetics and Biomembranes

21 August 2017

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21 August 2017

41

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21 August 2017

6

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21 August 2017

499-503

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https://scigraph.springernature.com/pub.10.1007/s10863-009-9253-3

21 August 2017

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cites work

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

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12 December 2020

The PINK1/Parkin pathway regulates mitochondrial morphology

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12 December 2020

Mechanistic approaches to Parkinson's disease pathogenesis.

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12 December 2020

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

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12 December 2020

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.

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12 December 2020

Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice

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12 December 2020

Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes

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12 December 2020

Parkinson's disease: from causes to mechanisms

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12 December 2020

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

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12 December 2020

Mitochondrial dysfunction in Parkinson's disease

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12 December 2020

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

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12 December 2020

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin

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12 December 2020

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

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12 December 2020

Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions

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12 December 2020

Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice

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12 December 2020

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons.

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12 December 2020

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

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12 December 2020

DJ-1 and Parkin modulate dopamine-dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice

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12 December 2020

Molecular pathogenesis of Parkinson disease: insights from genetic studies

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12 December 2020

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

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12 December 2020

Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.

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12 December 2020

The kinase domain of mitochondrial PINK1 faces the cytoplasm

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12 December 2020

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

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12 December 2020

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

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12 December 2020

Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells

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12 December 2020

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

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12 December 2020

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

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12 December 2020

Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission

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12 December 2020

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

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12 December 2020

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

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12 December 2020

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

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12 December 2020

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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12 December 2020

Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice.

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12 December 2020

Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

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12 December 2020

Functions and dysfunctions of mitochondrial dynamics

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12 December 2020

Expanding insights of mitochondrial dysfunction in Parkinson's disease.

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12 December 2020

Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.

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12 December 2020

Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells

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12 December 2020

Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

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12 December 2020

PINK1 protein in normal human brain and Parkinson's disease

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12 December 2020

The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process.

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12 December 2020

Characterization of PINK1 processing, stability, and subcellular localization

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12 December 2020

10.1007/S10863-009-9253-3

Identifiers

DOI

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21 August 2017

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PubMed ID

19967438