EFEMP1 induces γ-secretase/Notch-mediated temozolomide resistance in glioblastoma (Q37660295)

21 August 2017

EFEMP1 induces γ-secretase/Notch-mediated temozolomide resistance in glioblastoma (English)

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21 August 2017

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Lotte Hiddingh

1

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21 August 2017

Bakhos A Tannous

2

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21 August 2017

Jian Teng

3

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21 August 2017

Bas Tops

4

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21 August 2017

Judith Jeuken

5

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21 August 2017

Esther Hulleman

6

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21 August 2017

Sandra H Boots-Sprenger

7

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21 August 2017

W Peter Vandertop

8

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21 August 2017

David P Noske

9

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21 August 2017

Gertjan J L Kaspers

10

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21 August 2017

Pieter Wesseling

11

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21 August 2017

Thomas Wurdinger

12

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21 August 2017

language of work or name

English

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publication date

1 January 2014

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21 August 2017

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21 August 2017

5

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21 August 2017

2

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21 August 2017

363-374

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describes a project that uses

21 August 2017

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/3964213

inferred from PubMed Central ID database lookup

cites work

A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells

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Prolonged inhibition of glioblastoma xenograft initiation and clonogenic growth following in vivo Notch blockade

23 August 2017

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Efemp1 and p27(Kip1) modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models

23 August 2017

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Fibulin-3 as a blood and effusion biomarker for pleural mesothelioma

23 August 2017

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MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

23 August 2017

1 reference

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Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling

23 August 2017

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23 August 2017

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Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma

23 August 2017

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Down-regulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2

23 August 2017

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Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133(+) glioma stem cells to temozolomide therapy

23 August 2017

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Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence

23 August 2017

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Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease

23 August 2017

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The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis.

23 August 2017

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

23 August 2017

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Fibulin-3 is uniquely upregulated in malignant gliomas and promotes tumor cell motility and invasion

23 August 2017

1 reference

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EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells

23 August 2017

1 reference

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The ABCG2 resistance network of glioblastoma

23 August 2017

1 reference

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MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance.

23 August 2017

1 reference

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Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia

23 August 2017

1 reference

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Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

23 August 2017

1 reference

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Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age

23 August 2017

1 reference

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23 August 2017

1 reference

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Mechanisms of chemoresistance to alkylating agents in malignant glioma

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

A secreted luciferase for ex vivo monitoring of in vivo processes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology

23 August 2017

1 reference

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Fibulins and cancer: friend or foe?

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

MGMT gene silencing and benefit from temozolomide in glioblastoma

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Fibulins: physiological and disease perspectives.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Significance analysis of microarrays applied to the ionizing radiation response

23 August 2017

1 reference

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Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Canonical and non-canonical Notch ligands

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

A role for the transcription factor HEY1 in glioblastoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Contribution of Notch signaling activation to human glioblastoma multiforme.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Primary glioblastomas express mesenchymal stem-like properties

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Predictive impact of MGMT promoter methylation in glioblastoma of the elderly

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Blood platelets contain tumor-derived RNA biomarkers.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

EFEMP1 expression promotes in vivo tumor growth in human pancreatic adenocarcinoma

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Gene expression profiling of gliomas strongly predicts survival

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3964213

Fibulin-3 is associated with tumour progression and a poor prognosis in nasopharyngeal carcinomas and inhibits cell migration and invasion via suppressed AKT activity

2 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24495907

12 December 2020

inferred from PubMed ID database lookup

Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24495907

12 December 2020

inferred from PubMed ID database lookup

EFEMP1 expression promotes angiogenesis and accelerates the growth of cervical cancer in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24495907

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.18632/ONCOTARGET.1620

0 references

1 reference

21 August 2017

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