Unraveling the complexity of neurodegeneration in brains of subjects with Down syndrome: insights from proteomics. (Q37662773)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24259517%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Unraveling the complexity of neurodegeneration in brains of subjects with Down syndrome: insights from proteomics (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24259517%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

1 reference

2

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1 March 2020

author name string

Marzia Perluigi

series ordinal

1

1 reference

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1 March 2020

D Allan Buttterfield

series ordinal

3

1 reference

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1 March 2020

language of work or name

1 reference

1 February 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24259517%20AND%20SRC:MED&resulttype=core&format=json

Proteomics - Clinical Applications

1 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24259517%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

volume

8

1 reference

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1 March 2020

issue

1-2

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1 March 2020

page(s)

73-85

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Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain.

1 March 2020

cites work

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Normal protein composition of synapses in Ts65Dn mice: a mouse model of Down syndrome

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Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801.

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Application of proteomics for the identification of differentially expressed protein markers for Down syndrome in maternal plasma

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23 August 2017

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6 September 2017

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6 September 2017

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ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway

14 September 2017

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Proteasomes: multicatalytic proteinase complexes

14 September 2017

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Ets-2 is induced by oxidative stress and sensitizes cells to H(2)O(2)-induced apoptosis: implications for Down's syndrome

14 September 2017

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Possible involvement of proteasome inhibition in aging: implications for oxidative stress.

28 September 2017

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Are reactive oxygen species involved in Alzheimer's disease?

28 September 2017

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The effect of amyloid associated proteins on the expression of genes involved in amyloid-β clearance by adult human astrocytes.

28 September 2017

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Life-long overexpression of S100beta in Down's syndrome: implications for Alzheimer pathogenesis

25 June 2018

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Ubiquitin pools, ubiquitin mRNA levels, and ubiquitin-mediated proteolysis in aging human fibroblasts

25 June 2018

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Molecular mapping of twenty-four features of Down syndrome on chromosome 21.

25 June 2018

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A mouse model for Down syndrome exhibits learning and behaviour deficits.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Alzheimer's disease in Down's syndrome: clinicopathologic studies

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Altered composition of polyunsaturated fatty acyl groups in phosphoglycerides of Down's syndrome fetal brain

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Verification of a biomarker discovery approach for detection of Down syndrome in amniotic fluid via multiplex selected reaction monitoring (SRM) assay.

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

A gel-based proteomic method reveals several protein pathway abnormalities in fetal Down syndrome brain.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Comparative proteomic analysis of human amniotic fluid supernatants with Down syndrome using mass spectrometry.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Amniotic fluid proteome analysis from Down syndrome pregnancies for biomarker discovery

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Down's syndrome in diabetic patients aged <20 years: an analysis of metabolic status, glycaemic control and autoimmunity in comparison with type 1 diabetes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Increased lipid peroxidation in Down's syndrome mouse models.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

An apolipoprotein A-I gene promoter polymorphism associated with cognitive decline, but not with Alzheimer's disease

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Increased amyloid beta protein levels in children and adolescents with Down syndrome

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Increased prevalence of Down's syndrome in individuals with type 1 diabetes in Denmark: A nationwide population-based study.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Protein dysregulation in mouse hippocampus polytransgenic for chromosome 21 structures in the Down Syndrome Critical Region.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Dosage-dependent over-expression of genes in the trisomic region of Ts1Cje mouse model for Down syndrome.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Cystatin-B is expressed by neural stem cells and by differentiated neurons and astrocytes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Proteomic evaluation of intermediary metabolism enzyme proteins in fetal Down's syndrome cerebral cortex

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Relation of medial temporal lobe volumes to age and memory function in nondemented adults with Down's syndrome: implications for the prodromal phase of Alzheimer's disease.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Immunohistochemical distribution of the receptor for advanced glycation end products in neurons and astrocytes in Alzheimer's disease

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Type 1 diabetes mellitus and Down's syndrome: prevalence, management and diabetic complications.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

How do intracellular proteolytic systems change with age?

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Free radical damage in Down's syndrome brain

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Susceptibility of glucose-6-phosphate dehydrogenase modified by 4-hydroxy-2-nonenal and metal-catalyzed oxidation to proteolysis by the multicatalytic protease.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

S100 beta expression in Alzheimer's disease: relation to neuropathology in brain regions.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3965623

Differential gene expression studies to explore the molecular pathophysiology of Down syndrome

1 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FPRCA.201300066

Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome

21 January 2018

1 reference

12 December 2020

Antioxidant enzymes and fatty acid status in erythrocytes of Down's syndrome patients

1 reference

12 December 2020

Parental origin of the extra chromosome in trisomy 21 as indicated by analysis of DNA polymorphisms. Down Syndrome Collaborative Group

1 reference

12 December 2020

Down's syndrome is associated with increased 8,12-iso-iPF2alpha-VI levels: evidence for enhanced lipid peroxidation in vivo

1 reference

12 December 2020

Isolation and identification of the major heparan sulfate proteoglycans in the developing bovine rib growth plate

1 reference

12 December 2020

Preliminary proteomic-based identification of a novel protein for Down's syndrome in maternal serum

1 reference

12 December 2020

Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid

1 reference

12 December 2020

Are serum protein biomarkers derived from proteomic analysis useful in screening for trisomy 21 at 11-13 weeks?

1 reference

12 December 2020

The multicatalytic proteinase. Multiple proteolytic activities

1 reference

12 December 2020

Overexpression of s100beta in Down's syndrome: correlation with patient age and with beta-amyloid deposition

1 reference

12 December 2020

Identifiers

DOI

10.1002/PRCA.201300066

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24259517%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24259517%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

24259517

1 reference