Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia (Q35606429)

9 August 2017

Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia (English)

1 reference

9 August 2017

0 references

0 references

1 reference

2

D Allan Butterfield

1 reference

9 August 2017

Marzia Perluigi

1

1 reference

9 August 2017

29 November 2011

1 reference

Current gerontology and geriatrics research

9 August 2017

1 reference

9 August 2017

2012

1 reference

9 August 2017

724904

1 reference

Creative Commons Attribution 3.0 Unported

9 August 2017

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Mouse models for Down syndrome-associated developmental cognitive disabilities

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

The use of mouse models to understand and improve cognitive deficits in Down syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Proteomic analysis of amniotic fluid for the diagnosis of fetal aneuploidies

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Evaluation of urinary biomarkers of oxidative/nitrosative stress in adolescents and adults with Down syndrome.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Impairment of methyl cycle affects mitochondrial methyl availability and glutathione level in Down's syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Change in plasma Aß peptides and onset of dementia in adults with Down syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Emerging biological importance of central nervous system lanthionines.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Aneuploidy: from a physiological mechanism of variance to Down syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Molecular genetic analysis of Down syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Mutations in the Chinese hamster ovary cell GART gene of de novo purine synthesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Mechanisms of disease: DNA repair defects and neurological disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Beta-amyloid, oxidative stress and down syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Age-dependent oxidative stress-induced DNA damage in Down's lymphocytes.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Oxidative stress: a bridge between Down's syndrome and Alzheimer's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Alzheimer's disease and endocytic dysfunction: clues from the Down syndrome-related proteins, DSCR1 and ITSN1

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

mtDNA mutations and common neurodegenerative disorders

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Amniotic fluid: not just fetal urine anymore

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Down syndrome and genetics - a case of linked histories.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Aberrant neuronal and mitochondrial proteins in hippocampus of transgenic mice overexpressing human Cu/Zn superoxide dismutase 1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Down syndrome and beta-amyloid deposition

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Risk factors for dementia in people with down syndrome: issues in assessment and diagnosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Mitochondrial dysfunction and Down's syndrome.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Brain hydrogen sulfide is severely decreased in Alzheimer's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Antioxidant proteins in fetal brain: superoxide dismutase-1 (SOD-1) protein is not overexpressed in fetal Down syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down syndrome and Alzheimer's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Down syndrome and Alzheimer's disease: a link between development and aging

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Increased mitochondrial superoxide generation in neurons from trisomy 16 mice: a model of Down's syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Down syndrome: advances in molecular biology and the neurosciences

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Oxidative stress and neural dysfunction in Down syndrome.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Mitochondrial diseases in man and mouse

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Cytoplasmic abnormalities in cultured cerebellar neurons from the trisomy 16 mouse.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Are reactive oxygen species involved in Alzheimer's disease?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

The gene for cystathionine beta-synthase (CBS) maps to the subtelomeric region on human chromosome 21q and to proximal mouse chromosome 17

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

The regulation of amyloid beta protein precursor secretion and its modulatory role in cell adhesion

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Relation of medial temporal lobe volumes to age and memory function in nondemented adults with Down's syndrome: implications for the prodromal phase of Alzheimer's disease.

12 July 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Biomarkers of oxidative stress are significantly elevated in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Oxidative damage is the earliest event in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Increased lipid peroxidation in Down's syndrome mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Amyloid-beta impairs development of neuronal progenitor cells by oxidative mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Increased amyloid beta protein levels in children and adolescents with Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

In vivo effects of APP are not exacerbated by BACE2 co-overexpression: behavioural characterization of a double transgenic mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Cystathionine beta-synthase is enriched in the brains of Down's patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Mental retardation in Down syndrome: a hydrogen sulfide hpothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Cystathionine beta synthase as a risk factor for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

The astroglial-derived S100beta protein stimulates the expression of nitric oxide synthase in rodent macrophages through p38 MAP kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Early glycoxidation damage in brains from Down's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Urinary biomarkers of oxidative/nitrosative stress in healthy smokers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Amniotic fluid proteome analysis from Down syndrome pregnancies for biomarker discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

DSCR1(Adapt78) modulates expression of SOD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Mitochondrial dysfunction in mouse trisomy 16 brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Oxidative metabolites of 5-S-cysteinyldopamine inhibit the pyruvate dehydrogenase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Multiple evidence for an early age pro-oxidant state in Down Syndrome patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Early oxidative stress in amniotic fluid of pregnancies with Down syndrome

25 September 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F724904

Clinical, social, and ethical implications of changing life expectancy in Down syndrome

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3235450

Overexpression of s100beta in Down's syndrome: correlation with patient age and with beta-amyloid deposition

15 November 2018

1 reference

12 December 2020

Down's syndrome is associated with increased 8,12-iso-iPF2alpha-VI levels: evidence for enhanced lipid peroxidation in vivo

1 reference

12 December 2020

Endogenous hydrogen sulfide overproduction in Down syndrome

1 reference

12 December 2020

The amyloid precursor protein and its network of interacting proteins: physiological and pathological implications

1 reference

12 December 2020

Mitochondrial alterations and tendency to apoptosis in peripheral blood cells from children with Down syndrome

1 reference

12 December 2020

Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid

1 reference

12 December 2020

Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation

1 reference

12 December 2020

A mitochondrial etiology of Alzheimer and Parkinson disease

1 reference

12 December 2020

Cu/Zn-superoxide dismutase and glutathione peroxidase during aging

1 reference

12 December 2020

Mitochondrial enzyme deficiencies in Down's syndrome

1 reference

12 December 2020

Defective repair of oxidative damage in mitochondrial DNA in Down's syndrome

1 reference

12 December 2020

Identifiers

DOI

10.1155/2012/724904

1 reference

release_vozviaei3zam7nd6xdxvzu6iyi

9 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/vozviaei3zam7nd6xdxvzu6iyi

24 November 2022

mapped directly with Wikidata item

PMCID

3235450

1 reference

9 August 2017

1 reference

PubMed ID

22203843