Rap1, a mercenary among the Ras-like GTPases (Q37671129)

21 August 2017

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title

Rap1, a mercenary among the Ras-like GTPases (English)

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21 August 2017

E W Frische

1

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21 August 2017

F J T Zwartkruis

series ordinal

2

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21 August 2017

language of work or name

English

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publication date

7 January 2010

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21 August 2017

number of pages

9

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based on heuristic

inferred from page(s)

published in

Developmental Biology

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21 August 2017

volume

340

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21 August 2017

issue

1

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21 August 2017

page(s)

1-9

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Mitogenic and oncogenic properties of the small G protein Rap1b

21 August 2017

cites work

1 reference

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Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors

7 January 2021

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The Rap1 GTPase functions as a regulator of morphogenesis in vivo

7 January 2021

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Activation of Rap1 promotes prostate cancer metastasis

7 January 2021

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Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1.

7 January 2021

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The Rap GTPase activator Drosophila PDZ-GEF regulates cell shape in epithelial migration and morphogenesis

7 January 2021

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GEFs and GAPs: critical elements in the control of small G proteins

7 January 2021

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Role of small G proteins in yeast cell polarization and wall biosynthesis

7 January 2021

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Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis

7 January 2021

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The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators

7 January 2021

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Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway

7 January 2021

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Biological characterization of Drosophila Rapgap1, a GTPase activating protein for Rap1

7 January 2021

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Rap1b is required for normal platelet function and hemostasis in mice

7 January 2021

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Defective angiogenesis, endothelial migration, proliferation, and MAPK signaling in Rap1b-deficient mice.

7 January 2021

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Rap1b regulates B cell development, homing, and T cell-dependent humoral immunity

7 January 2021

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Dictyostelium: an ideal organism for genetic dissection of Ras signalling networks.

7 January 2021

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Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway

7 January 2021

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Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Rap1A-deficient T and B cells show impaired integrin-mediated cell adhesion

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Activation of the Rap1 guanine nucleotide exchange gene, CalDAG-GEF I, in BXH-2 murine myeloid leukemia

7 January 2021

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The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Rapid Ca2+-mediated activation of Rap1 in human platelets

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

The Par polarity complex regulates Rap1- and chemokine-induced T cell polarization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Temporal and spatial regulation of Rho-type guanine-nucleotide exchange factors: the yeast perspective

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Shroom induces apical constriction and is required for hingepoint formation during neural tube closure

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Rap1 regulates the formation of E-cadherin-based cell-cell contacts.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Regulation of E-cadherin endocytosis by nectin through afadin, Rap1, and p120ctn

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

The PDZ-GEF dizzy regulates cell shape of migrating macrophages via Rap1 and integrins in the Drosophila embryo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Dynamic analysis of dorsal closure in Drosophila: from genetics to cell biology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Rap1 controls cell adhesion and cell motility through the regulation of myosin II.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Rap1 GTPase regulation of adherens junction positioning and cell adhesion.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Epac1 regulates integrity of endothelial cell junctions through VE-cadherin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Highlighting the role of Ras and Rap during Dictyostelium chemotaxis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Characterization of the GbpD-activated Rap1 pathway regulating adhesion and cell polarity in Dictyostelium discoideum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Kindlins: essential regulators of integrin signalling and cell-matrix adhesion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Myosin VI and vinculin cooperate during the morphogenesis of cadherin cell cell contacts in mammalian epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Pulsed contractions of an actin-myosin network drive apical constriction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Regulation of cell-cell junctions by the cytoskeleton.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

A mechanism of Bud1p GTPase action suggested by mutational analysis and immunolocalization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Ras-independent activation of ERK signaling via the torso receptor tyrosine kinase is mediated by Rap1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Rap1GAP promotes invasion via induction of matrix metalloproteinase 9 secretion, which is associated with poor survival in low N-stage squamous cell carcinoma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

The little R cell that could

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Regulation of Rap1 activity is required for differential adhesion, cell-type patterning and morphogenesis in Dictyostelium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Rap1 regulates E-cadherin-mediated cell-cell adhesion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Specificity in Ras and Rap signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Altered morphology of vegetative amoebae induced by increased expression of the Dictyostelium discoideum ras-related gene rap1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Mutational analysis of the role of Rap1 in regulating cytoskeletal function in Dictyostelium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

The small GTPase, Rap1, mediates CD31-induced integrin adhesion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

The small Mr Ras-like GTPase Rap1 and the phospholipase C pathway act to regulate phagocytosis in Dictyostelium discoideum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

A two-hybrid dual bait system to discriminate specificity of protein interactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

RalA but not RalB enhances polarized delivery of membrane proteins to the basolateral surface of epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

The high-risk human papillomavirus type 16 E6 counters the GAP function of E6TP1 toward small Rap G proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Conserved patterns of cell movements during vertebrate gastrulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

The guanine nucleotide exchange factor C3G is necessary for the formation of focal adhesions and vascular maturation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Pattern formation during C. elegans vulval induction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

DOCK4, a GTPase activator, is disrupted during tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YDBIO.2009.12.043

10.1016/J.YDBIO.2009.12.043

7 January 2021

Identifiers

DOI

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21 August 2017

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