The NLRP3 inflammasome: a sensor for metabolic danger? (Q37675505)

21 August 2017

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title

The NLRP3 inflammasome: a sensor for metabolic danger? (English)

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21 August 2017

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1

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21 August 2017

3

Jurg Tschopp

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21 August 2017

2

Rongbin Zhou

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PubMed ID

20075245

21 August 2017

language of work or name

English

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publication date

1 January 2010

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21 August 2017

5

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based on heuristic

inferred from page(s)

published in

Science

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21 August 2017

327

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21 August 2017

296-300

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21 August 2017

5963

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Interleukin-1 beta targeted therapy for type 2 diabetes

21 August 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Increased number of islet-associated macrophages in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

The inflammasomes: guardians of the body

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

An interleukin-1 receptor antagonist protein protects insulin-producing Beta cells against suppressive effects of interleukin-1?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Adenoviral overexpression of interleukin-1 receptor antagonist protein increases beta-cell replication in rat pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Sensing pathogens and danger signals by the inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Molecular mechanisms involved in inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

CA-074Me protection against anthrax lethal toxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

The Nalp3 inflammasome is essential for the development of silicosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Txnip balances metabolic and growth signaling via PTEN disulfide reduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Thioredoxin binding protein-2/thioredoxin-interacting protein is a critical regulator of insulin secretion and peroxisome proliferator-activated receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

TXNIP regulates peripheral glucose metabolism in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Gout-associated uric acid crystals activate the NALP3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

A pilot study of IL-1 inhibition by anakinra in acute gout

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Type 2 Diabetes Mellitus: New Genetic Insights will Lead to New Therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

TLR4 links innate immunity and fatty acid-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Intracerebroventricular administration of a specific IL-1 receptor antagonist blocks food and water intake suppression induced by interleukin-1 beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

Fungal zymosan and mannan activate the cryopyrin inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1184003

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1184003

1 reference

21 August 2017

0 references

1 reference

PubMed ID

20075245