Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes (Q35184167)

7 August 2017

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title

Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes (English)

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7 August 2017

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Joachim Størling

2

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Thomas Mandrup-Poulsen

object named as

Thomas Mandrup-Poulsen

series ordinal

4

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Kathrin Maedler

object named as

Kathrin Maedler

series ordinal

3

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Marc Y Donath

series ordinal

1

object named as

Marc Y Donath

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7 August 2017

publication date

18 July 2003

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Journal of Molecular Medicine

7 August 2017

published in

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7 August 2017

volume

81

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7 August 2017

issue

8

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7 August 2017

page(s)

455-470

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https://scigraph.springernature.com/pub.10.1007/s00109-003-0450-y

7 August 2017

exact match

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cites work

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Islet growth and development in the adult

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Short-term exposure of rat pancreatic islets to human interleukin-1 beta increases cellular uptake of calcium

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Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

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Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis

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FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication

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Cytokines suppress human islet function irrespective of their effects on nitric oxide generation

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Insulin resistance is not necessarily an essential component of type 2 diabetes

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Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F.

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Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors

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The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus

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The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

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Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes

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Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia

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Inhibition of NF-kappa B by sodium salicylate and aspirin

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Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.

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Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor

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Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.

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Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes?

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Increased levels of acute-phase serum proteins in diabetes.

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Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase

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Cytokines induce both necrosis and apoptosis via a common Bcl-2-inhibitable pathway in rat insulin-producing cells

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Inhibition of protein kinase C delta protects rat INS-1 cells against interleukin-1beta and streptozotocin-induced apoptosis

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Prevention of fat-induced insulin resistance by salicylate

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beta-cell apoptosis: stimuli and signaling

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Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction

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Immune attack on pancreatic islet transplants in the spontaneously diabetic BioBreeding/Worcester (BB/W) rat is not MHC restricted

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A central role for JNK in obesity and insulin resistance

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Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model.

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A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus

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Expression of apoptosis-inducing CD95 (Fas/Apo-1) on human beta-cells sorted by flow-cytometry and cultured in vitro

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Apoptosis in insulin-secreting cells. Evidence for the role of intracellular Ca2+ stores and arachidonic acid metabolism

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The role of interleukin-1 in the pathogenesis of IDDM.

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Expression of calbindin-D(28k) in a pancreatic islet beta-cell line protects against cytokine-induced apoptosis and necrosis

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12 December 2020

Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

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Protein kinase Cdelta activation by interleukin-1beta stabilizes inducible nitric-oxide synthase mRNA in pancreatic beta-cells

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12 December 2020

Combined treatment with nicotinamide and desferrioxamine prevents islet allograft destruction in NOD mice

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12 December 2020

Apoptosis by death factor

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12 December 2020

High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

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Biologic functions of the IFN-gamma receptors

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Autoimmune islet destruction in spontaneous type 1 diabetes is not beta-cell exclusive.

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Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity

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12 December 2020

Development of type 1 diabetes despite severe hereditary B-cell deficiency

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Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes

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12 December 2020

Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays

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12 December 2020

Antibodies to Glutamic Acid Decarboxylase Discriminate Major Types of Diabetes Mellitus

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12 December 2020

Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.

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12 December 2020

Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway

1 reference

12 December 2020

Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro

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12 December 2020

Is type 2 diabetes a chronic inflammatory/autoimmune disease?

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12 December 2020

Beta-cell maturation leads to in vitro sensitivity to cytotoxins

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12 December 2020

A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis

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12 December 2020

Islet-specific T cell clones transfer diabetes to nonobese diabetic (NOD) F1 mice.

1 reference

12 December 2020

Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus

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12 December 2020

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

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12 December 2020

Cytokines activate the nuclear factor kappa B (NF-kappa B) and induce nitric oxide production in human pancreatic islets

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12 December 2020

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

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12 December 2020

The pancreatic islets in diabetes

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12 December 2020

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

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12 December 2020

The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes

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12 December 2020

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

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12 December 2020

Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases

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12 December 2020

TNF-induced signaling in apoptosis

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12 December 2020

Fetal pancreatic islets express functional leptin receptors and leptin stimulates proliferation of fetal islet cells

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12 December 2020

Arterial inflammation and atherosclerosis

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12 December 2020

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

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12 December 2020

The innate immune response and type 2 diabetes: evidence that leptin is associated with a stress-related (acute-phase) reaction.

1 reference

12 December 2020

The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense

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12 December 2020

Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid

1 reference

12 December 2020

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

12 December 2020

TNFalpha and IFNgamma potentiate IL-1beta induced mitogen activated protein kinase activity in rat pancreatic islets of Langerhans

1 reference

12 December 2020

Interleukin-1beta stimulation of c-Jun NH(2)-terminal kinase activity in insulin-secreting cells: evidence for cytoplasmic restriction

1 reference

12 December 2020

Activation of nuclear factor-kappaB by depolarization and Ca(2+) influx in MIN6 insulinoma cells

1 reference

12 December 2020

Blood glycoprotein levels in diabetes mellitus

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12 December 2020

Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation

1 reference

12 December 2020

Diabetes in identical twins. A study of 200 pairs

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12 December 2020

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

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12 December 2020

The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells

1 reference

12 December 2020

Mediators of cytokine-induced insulin resistance in obesity and other inflammatory settings

1 reference

12 December 2020

Low concentrations of interleukin-1 stimulate and high concentrations inhibit insulin release from isolated rat islets of Langerhans

1 reference

12 December 2020

A low voltage-activated Ca2+ current mediates cytokine-induced pancreatic beta-cell death

1 reference

12 December 2020

Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells

1 reference

12 December 2020

Processing of engulfed apoptotic bodies yields T cell epitopes

1 reference

12 December 2020

Double-stranded RNA inhibits beta-cell function and induces islet damage by stimulating beta-cell production of nitric oxide

1 reference

12 December 2020

Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study

1 reference

12 December 2020

Serum concentration of alpha-2-macroglobulin, haptoglobin and alpha-1-antitrypsin in diabetes mellitus

1 reference

12 December 2020

No decrease of the beta-cell mass in type 2 diabetic patients

1 reference

12 December 2020

Evidence of islet cell autoimmunity in elderly patients with type 2 diabetes

1 reference

12 December 2020

Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects.

1 reference

12 December 2020

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

1 reference

12 December 2020

NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X.

1 reference

12 December 2020

Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells

1 reference

12 December 2020

Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism

1 reference

12 December 2020

A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells

1 reference

12 December 2020

Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

1 reference

12 December 2020

Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program

1 reference

12 December 2020

IL-1 receptor antagonist serum levels are increased in human obesity: a possible link to the resistance to leptin?

1 reference

12 December 2020

Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease

1 reference

12 December 2020

Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression

1 reference

12 December 2020

Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited.

1 reference

12 December 2020

Leptin induces proliferation of pancreatic beta cell line MIN6 through activation of mitogen-activated protein kinase

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12 December 2020

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

1 reference

12 December 2020

Latent autoimmune diabetes mellitus in adults (LADA): the role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency

1 reference

12 December 2020

Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement

1 reference

12 December 2020

Is type II diabetes mellitus a disease of the innate immune system?

1 reference

12 December 2020

Insulin deficiency and insulin resistance in the pathogenesis of NIDDM: is a divorce possible?

1 reference

12 December 2020

Cyclosporin-induced remission of IDDM after early intervention. Association of 1 yr of cyclosporin treatment with enhanced insulin secretion. The Canadian-European Randomized Control Trial Group

1 reference

12 December 2020

TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

1 reference

12 December 2020

How cells respond to interferons

1 reference

12 December 2020

Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells

1 reference

12 December 2020

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

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12 December 2020

beta-Adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies

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12 December 2020

Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations

1 reference

12 December 2020

Pancreatic beta-cell damage mediated by beta-cell production of interleukin-1. A novel mechanism for virus-induced diabetes

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12 December 2020

Viruses and other perinatal exposures as initiating events for beta-cell destruction

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12 December 2020

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

1 reference

12 December 2020

Independent associations between plasma lipoprotein subfraction levels and the course of coronary artery disease in the St. Thomas' Atherosclerosis Regression Study (STARS)

1 reference

12 December 2020

Insulin resistance or insulin deficiency. Which is the primary cause of NIDDM?

1 reference

12 December 2020

Mouse islet cell lysis mediated by interleukin-1-induced Fas.

1 reference

12 December 2020

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

1 reference

12 December 2020

Beta-cell destruction in NOD mice correlates with Fas (CD95) expression on beta-cells and proinflammatory cytokine expression in islets

1 reference

12 December 2020

Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing

1 reference

12 December 2020

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

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12 December 2020

Relationship between plasma plasminogen activator inhibitor 1 and insulin resistance

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12 December 2020

Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis.

1 reference

12 December 2020

The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells

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12 December 2020

Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities

1 reference

12 December 2020

Perspective: the search for genes for type 2 diabetes in the post-genome era.

1 reference

12 December 2020

Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression

1 reference

12 December 2020

Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial.

1 reference

12 December 2020

Proinflammation: a common denominator or initiator of different pathophysiological disease processes.

1 reference

12 December 2020

Destruction of rat islet cell monolayers by cytokines. Synergistic interactions of interferon-gamma, tumor necrosis factor, lymphotoxin, and interleukin 1

1 reference

12 December 2020

Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic beta-cells.

1 reference

12 December 2020

Leptin increases the viability of isolated rat pancreatic islets by suppressing apoptosis

1 reference

12 December 2020

Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes

1 reference

12 December 2020

Fatty acids, lipotoxicity and insulin secretion

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12 December 2020

Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

1 reference

12 December 2020

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

1 reference

12 December 2020

10.1007/S00109-003-0450-Y

Identifiers

DOI

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7 August 2017

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