How chronic viral infections impact on antigen-specific T-cell responses (Q37676100)

21 August 2017

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title

How chronic viral infections impact on antigen-specific T-cell responses (English)

1 reference

21 August 2017

3

Annette Oxenius

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21 August 2017

Helge Frebel

1

1 reference

PubMed ID

20077405

21 August 2017

Kirsten Richter

series ordinal

2

1 reference

PubMed ID

20077405

21 August 2017

language of work or name

English

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publication date

1 March 2010

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European Journal of Immunology

21 August 2017

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21 August 2017

40

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21 August 2017

3

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21 August 2017

654-663

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Rapid functional exhaustion and deletion of CTL following immunization with recombinant adenovirus

21 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

Ablation of CD8 and CD4 T cell responses by high viral loads

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

Complement-dependent enhancement of CD8+ T cell immunity to lymphocytic choriomeningitis virus infection in decay-accelerating factor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

Chronic lymphocytic choriomeningitis virus infection actively down-regulates CD4+ T cell responses directed against a broad range of epitopes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

Expansion and contraction of HIV-specific CD4 T cells with short bursts of viremia, but physical loss of the majority of these cells with sustained viral replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

Effects of sustained HIV-1 plasma viremia on HIV-1 Gag-specific CD4+ T cell maturation and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Sustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C Virus

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Cytotoxic T lymphocyte responses to human immunodeficiency virus: control and escape.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Functional discrepancies in HIV-specific CD8+ T-lymphocyte populations are related to plasma virus load

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Persistent numbers of tetramer+ CD8(+) T cells, but loss of interferon-gamma+ HIV-specific T cells during progression to AIDS

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Functional impairment of simian immunodeficiency virus-specific CD8+ T cells during the chronic phase of infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Antiviral CD8+ T cell responses in neonatal mice: susceptibility to polyoma virus-induced tumors is associated with lack of cytotoxic function by viral antigen-specific T cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

CD8+ T-cell dysfunction due to cytolytic granule deficiency in persistent Friend retrovirus infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Antigen-independent memory CD8 T cells do not develop during chronic viral infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Viral immune evasion due to persistence of activated T cells without effector function

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Molecular signature of CD8+ T cell exhaustion during chronic viral infection.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Skewed maturation of memory HIV-specific CD8 T lymphocytes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Interleukin-10 determines viral clearance or persistence in vivo

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Resolution of a chronic viral infection after interleukin-10 receptor blockade

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

A vital role for interleukin-21 in the control of a chronic viral infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

IL-21 is required to control chronic viral infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Tissue-specific abundance of regulatory T cells correlates with CD8+ T cell dysfunction and chronic retrovirus loads

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

High antigen levels are the cause of T cell exhaustion during chronic viral infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapy

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Chronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustion

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8+ T cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Critical role for perforin-, Fas/FasL-, and TNFR1-mediated cytotoxic pathways in down-regulation of antigen-specific T cells during persistent viral infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Dissection of antiviral and immune regulatory functions of tumor necrosis factor receptors in a chronic lymphocytic choriomeningitis virus infection.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Role of Bim in regulating CD8+ T-cell responses during chronic viral infection.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Control of virus-specific CD8+ T-cell exhaustion and immune-mediated pathology by E3 ubiquitin ligase Cbl-b during chronic viral infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Restoring function in exhausted CD8 T cells during chronic viral infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Elimination of chronic viral infection by blocking CD27 signaling.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Apoptotic regulation of T cells and absence of immune deficiency in virus-infected gamma interferon receptor knockout mice

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Upregulation of PD-1 Expression on Circulating and Intrahepatic Hepatitis C Virus-Specific CD8+ T Cells Associated with Reversible Immune Dysfunction

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Enhancing SIV-specific immunity in vivo by PD-1 blockade

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Virus-specific CD8 T cells: activation, differentiation and memory formation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

The role of CD4(+) T helper cells in the cytotoxic T lymphocyte response to HIV-1.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Impaired antibody response causes persistence of prototypic T cell-contained virus

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Requirement of B cells for generating CD4+ T cell memory

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

T-cell regulation by CD4 regulatory T cells during hepatitis B and C virus infections: facts and controversies.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Regulatory T cells in virus infections

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Influence of interleukin-10 gene promoter polymorphisms on disease progression in patients chronically infected with hepatitis B virus

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Interleukin-10 - 1082 GG polymorphism influences the occurrence and the clinical characteristics of hepatitis C virus infection.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Antigen burden is major determinant of human immunodeficiency virus-specific CD8+ T cell maturation state: potential implications for therapeutic immunization

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

PD-1 expression and IL-2 loss of cytomegalovirus- specific T cells correlates with viremia and reversible functional anergy

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CD8+ T cells upon acute versus persistent viral infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Tracking Virus-Specific CD4+ T Cells during and after Acute Hepatitis C Virus Infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Detection of functionally altered hepatitis C virus-specific CD4+ T cells in acute and chronic hepatitis C

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Preferential loss of IL-2-secreting CD4+ T helper cells in chronic HCV infection.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Restoration of HCV-specific T cell functions by PD-1/PD-L1 blockade in HCV infection: effect of viremia levels and antiviral treatment.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Diminished Proliferation of Human Immunodeficiency Virus-Specific CD4+T Cells Is Associated with Diminished Interleukin-2 (IL-2) Production and Is Recovered by Exogenous IL-2

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunction

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

IL-10, T cell exhaustion and viral persistence

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Regulatory T cells in autoimmmunity*.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Regulatory lymphocytes and intestinal inflammation.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Strategies for use of IL-10 or its antagonists in human disease

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Immunobiology and pathogenesis of viral hepatitis

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

The role of IL-10 in mouse hepatitis virus-induced demyelinating encephalomyelitis.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200940102

7 January 2021

Identifiers

DOI

10.1002/EJI.200940102

1 reference

21 August 2017

1 reference

PubMed ID

20077405