Understanding inflammatory pain: ion channels contributing to acute and chronic nociception (Q37693805)

22 August 2017

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title

Understanding inflammatory pain: ion channels contributing to acute and chronic nociception (English)

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sensory perception of pain

22 August 2017

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4

Nikita Gamper

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John Linley

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John E Linley

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1

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Lezanne Ooi

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Lezanne Ooi

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3

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author name string

Kirstin Rose

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2

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22 August 2017

17 February 2010

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22 August 2017

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22 August 2017

459

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22 August 2017

657-669

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22 August 2017

5

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https://scigraph.springernature.com/pub.10.1007/s00424-010-0784-6

22 August 2017

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Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain

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Voltage is a partial activator of rat thermosensitive TRP channels

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Cell damage excites nociceptors through release of cytosolic ATP.

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Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia

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12 December 2020

Contribution of transient receptor potential vanilloid subfamily 1 to endothelin-1-induced thermal hyperalgesia

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12 December 2020

p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia

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12 December 2020

Dual regulation of TRPV1 by phosphoinositides.

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12 December 2020

The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity

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12 December 2020

A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons

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12 December 2020

Role of the peripheral heme oxygenase-carbon monoxide pathway on the nociceptive response of rats to the formalin test: evidence for a cGMP signaling pathway.

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12 December 2020

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12 December 2020

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12 December 2020

Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha.

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12 December 2020

Contribution of interaction between nitric oxide and cyclooxygenases to the production of prostaglandins in carrageenan-induced inflammation

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12 December 2020

Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin

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12 December 2020

Retigabine, the specific KCNQ channel opener, blocks ectopic discharges in axotomized sensory fibres

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12 December 2020

Functional and molecular aspects of renal prostaglandin receptors

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12 December 2020

Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

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12 December 2020

Activity-dependent neuronal plasticity following tissue injury and inflammation

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12 December 2020

Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1.

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12 December 2020

Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain.

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12 December 2020

TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury

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12 December 2020

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12 December 2020

Contribution of TRPV1 to the bradykinin-evoked nociceptive behavior and excitation of cutaneous sensory neurons

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12 December 2020

MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability.

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12 December 2020

Suppressed Ca2+/CaM/CaMKII-dependent K(ATP) channel activity in primary afferent neurons mediates hyperalgesia after axotomy

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12 December 2020

The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant

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12 December 2020

Impaired nociception and pain sensation in mice lacking the capsaicin receptor

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12 December 2020

Regulation of ion transport proteins by membrane phosphoinositides

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12 December 2020

Bradykinin excites rat sympathetic neurons by inhibition of M current through a mechanism involving B2 receptors and G alpha q/11.

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12 December 2020

The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose neurones

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12 December 2020

Acid increases inflammatory pain in rats: effect of local peripheral ASICs inhibitors

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12 December 2020

Transient receptor potential channels: targeting pain at the source

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12 December 2020

Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins

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12 December 2020

Ca2+ waves in keratinocytes are transmitted to sensory neurons: the involvement of extracellular ATP and P2Y2 receptor activation

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12 December 2020

Calmodulin mediates Ca2+-dependent modulation of M-type K+ channels

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12 December 2020

Brain-derived neurotrophic factor prevents axotomized retinal ganglion cell death through MAPK and PI3K signaling pathways.

1 reference

12 December 2020

Intracellular signaling in primary sensory neurons and persistent pain

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12 December 2020

Heme oxygenase type 2 participates in the development of chronic inflammatory and neuropathic pain

1 reference

12 December 2020

The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain

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12 December 2020

Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence

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12 December 2020

Induction of vanilloid receptor channel activity by protein kinase C

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12 December 2020

Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencing

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12 December 2020

PAR-2 agonists activate trigeminal nociceptors and induce functional competence in the delta opioid receptor

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12 December 2020

Inflammatory mediators modulating the transient receptor potential vanilloid 1 receptor: therapeutic targets to treat inflammatory and neuropathic pain

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12 December 2020

Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation

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12 December 2020

How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation

1 reference

12 December 2020

Increased acid-sensing ion channel ASIC-3 in inflamed human intestine

1 reference

12 December 2020

NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels.

1 reference

12 December 2020

G proteins of the Gq family couple the H2 histamine receptor to phospholipase C.

1 reference

12 December 2020

P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP

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12 December 2020

Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity.

1 reference

12 December 2020

Pre- and postsynaptic activation of M-channels by a novel opener dampens neuronal firing and transmitter release.

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12 December 2020

ASIC3, a sensor of acidic and primary inflammatory pain

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12 December 2020

Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150

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12 December 2020

Structural requirements for differential sensitivity of KCNQ K+ channels to modulation by Ca2+/calmodulin

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12 December 2020

Peripheral mechanisms underlying the essential role of P2X3,2/3 receptors in the development of inflammatory hyperalgesia.

1 reference

12 December 2020

MAPK activation in nociceptive neurons and pain hypersensitivity

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12 December 2020

Pharmacological dissection and distribution of NaN/Nav1.9, T-type Ca2+ currents, and mechanically activated cation currents in different populations of DRG neurons

1 reference

12 December 2020

Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor

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12 December 2020

Potent analgesic effects of GDNF in neuropathic pain states.

1 reference

12 December 2020

Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.

1 reference

12 December 2020

Inositol phosphates and cell signalling

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12 December 2020

Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate.

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12 December 2020

Structural determinant of TRPV1 desensitization interacts with calmodulin

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12 December 2020

Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).

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12 December 2020

ASIC2a and ASIC3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons

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12 December 2020

Retigabine reduces the excitability of unmyelinated peripheral human axons

1 reference

12 December 2020

Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons

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12 December 2020

The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels

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12 December 2020

Neurotrophin activation of NFAT-dependent transcription contributes to the regulation of pro-nociceptive genes.

1 reference

12 December 2020

Sensitization of vanilloid receptor 1 induced by bradykinin via the activation of second messenger signaling cascades in rat primary afferent neurons.

1 reference

12 December 2020

Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice.

1 reference

12 December 2020

c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity.

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12 December 2020

Stimulation of cyclic GMP production via a nitrosyl factor in sensory neuronal cultures by algesic or inflammatory agents

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12 December 2020

Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin

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12 December 2020

Mediation of primary afferent peripheral hyperalgesia by the cAMP second messenger system

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12 December 2020

Phospholipase C mediated modulation of TRPV1 channels.

1 reference

12 December 2020

The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

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12 December 2020

Characterization of proteinase-activated receptor 2 signalling and expression in rat hippocampal neurons and astrocytes

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12 December 2020

Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptors

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12 December 2020

TRP channels in disease

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12 December 2020

The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin

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12 December 2020

The presence and role of the tetrodotoxin-resistant sodium channel Na(v)1.9 (NaN) in nociceptive primary afferent neurons.

1 reference

12 December 2020

TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents

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12 December 2020

Marked attenuation of inflammatory mediator-induced C-fiber sensitization for mechanical and hypotonic stimuli in TRPV4-/- mice

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12 December 2020

A capsaicin-receptor homologue with a high threshold for noxious heat

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12 December 2020

The capsaicin receptor: a heat-activated ion channel in the pain pathway

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12 December 2020

Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis

1 reference

12 December 2020

P2Y receptor linked to phospholipase C: stimulation of neuro 2A cells by UTP and ATP and possible regulation by protein kinase C subtype epsilon

1 reference

12 December 2020

Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following inflammation near the nerve cell body

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12 December 2020

Inflammatory mediators increase Nav1.9 current and excitability in nociceptors through a coincident detection mechanism

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12 December 2020

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

1 reference

12 December 2020

Glial-derived neurotrophic factor upregulates expression of functional SNS and NaN sodium channels and their currents in axotomized dorsal root ganglion neurons.

1 reference

12 December 2020

Inhibition of M current in sensory neurons by exogenous proteases: a signaling pathway mediating inflammatory nociception.

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12 December 2020

PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents

1 reference

12 December 2020

Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors).

1 reference

12 December 2020

Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain

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12 December 2020

A P2X purinoceptor expressed by a subset of sensory neurons

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12 December 2020

Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats.

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12 December 2020

Coupling of two endothelin receptor subtypes to differing signal transduction in transfected Chinese hamster ovary cells

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12 December 2020

10.1007/S00424-010-0784-6

Identifiers

DOI

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22 August 2017

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PubMed ID

20162302