Endothelial dysfunction in diabetes: multiple targets for treatment (Q37711251)

22 August 2017

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title

Endothelial dysfunction in diabetes: multiple targets for treatment (English)

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22 August 2017

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Hong Ding

1

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PubMed ID

20238124

22 August 2017

Chris R Triggle

series ordinal

2

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22 August 2017

18 March 2010

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22 August 2017

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22 August 2017

459

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22 August 2017

6

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22 August 2017

977-994

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https://scigraph.springernature.com/pub.10.1007/s00424-010-0807-3

22 August 2017

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cites work

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Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects

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High glucose-induced downregulation of connexin 43 expression promotes apoptosis in microvascular endothelial cells.

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Elevated glucose impairs cAMP-mediated dilation by reducing Kv channel activity in rat small coronary smooth muscle cells

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Altered functional coupling of coronary K+ channels in diabetic dyslipidemic pigs is prevented by exercise

21 January 2018

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Structural alterations in subcutaneous small arteries of normotensive and hypertensive patients with non-insulin-dependent diabetes mellitus

21 January 2018

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Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease

21 January 2018

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High glucose-induced apoptosis through store-operated calcium entry and calcineurin in human umbilical vein endothelial cells

21 January 2018

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Determinants of renal microvascular response to ACh: afferent and efferent arteriolar actions of EDHF.

21 January 2018

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Determinants of renal afferent arteriolar actions of bradykinin: evidence that multiple pathways mediate responses attributed to EDHF

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Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?

21 January 2018

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12 December 2020

Hyperinsulinemia induces myocardial infarctions and arteriolar medial hypertrophy in spontaneously hypertensive rats

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12 December 2020

Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice

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12 December 2020

Different pathways with distinct properties conduct dilations in the microcirculation in vivo

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12 December 2020

Elevated plasma endothelin in patients with diabetes mellitus.

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12 December 2020

Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery.

1 reference

12 December 2020

Endothelial cell tetrahydrobiopterin: going with the flow

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12 December 2020

Modulation of endothelial cell KCa3.1 channels during endothelium-derived hyperpolarizing factor signaling in mesenteric resistance arteries.

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12 December 2020

The deleterious effect of high concentrations of D-glucose requires pro-inflammatory preconditioning

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12 December 2020

Regulation of superoxide production in neutrophils: role of calcium influx

1 reference

12 December 2020

Reduced EDHF responses and connexin activity in mesenteric arteries from the insulin-resistant obese Zucker rat.

1 reference

12 December 2020

Mechanism of non-capacitative Ca2+ influx in response to bradykinin in vascular endothelial cells

1 reference

12 December 2020

Amino acids and gaseous signaling.

1 reference

12 December 2020

Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability

1 reference

12 December 2020

HMG-CoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells

1 reference

12 December 2020

Reduced expression of endothelial connexin37 and connexin40 in hyperlipidemic mice: recovery of connexin37 after 7-day simvastatin treatment

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12 December 2020

Single-nucleotide polymorphisms in vascular Ca2+-activated K+-channel genes and cardiovascular disease

1 reference

12 December 2020

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels

1 reference

12 December 2020

High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms.

1 reference

12 December 2020

MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial

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12 December 2020

Upregulated TRPC1 channel in vascular injury in vivo and its role in human neointimal hyperplasia

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12 December 2020

The nuclear receptor LXR is a glucose sensor

1 reference

12 December 2020

Alterations in endothelium-dependent hyperpolarization and relaxation in mesenteric arteries from streptozotocin-induced diabetic rats

1 reference

12 December 2020

Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome

1 reference

12 December 2020

Attenuation of conducted vasodilatation in rat mesenteric arteries during hypertension: role of inwardly rectifying potassium channels.

1 reference

12 December 2020

Association of cardiovascular risk factors with markers of endothelial dysfunction in middle-aged men and women. Results from the MONICA/KORA Augsburg Study

1 reference

12 December 2020

The early effects of elevated glucose on endothelial function as a target in the treatment of type 2 diabetes.

1 reference

12 December 2020

Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components

1 reference

12 December 2020

D-Glucose sensing by a plasma membrane regulator of G signaling protein, AtRGS1.

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12 December 2020

Endothelial dysfunction in diabetes.

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12 December 2020

The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide.

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12 December 2020

UK Prospective Diabetes Study (UKPDS). VIII. Study design, progress and performance

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12 December 2020

Molecular insights and therapeutic targets for diabetic endothelial dysfunction

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12 December 2020

EDHF: bringing the concepts together

1 reference

12 December 2020

Exposure to elevated D-glucose concentrations modulates vascular endothelial cell vasodilatory response.

1 reference

12 December 2020

Acetylcholine-induced relaxation of peripheral arteries isolated from mice lacking endothelial nitric oxide synthase

1 reference

12 December 2020

Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture).

1 reference

12 December 2020

Endothelial dysfunction in the streptozotocin-induced diabetic apoE-deficient mouse

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12 December 2020

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease

1 reference

12 December 2020

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12 December 2020

Endothelium-dependent contractions: when a good guy turns bad!

1 reference

12 December 2020

Connexin37 protects against atherosclerosis by regulating monocyte adhesion

1 reference

12 December 2020

High glucose-induced oxidative stress increases transient receptor potential channel expression in human monocytes

1 reference

12 December 2020

Two distinct pathways account for EDHF-dependent dilatation in the gracilis artery of dyslipidaemic hApoB+/+ mice.

1 reference

12 December 2020

Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness

1 reference

12 December 2020

Reduced Ca2+-dependent activation of large-conductance Ca2+-activated K+ channels from arteries of Type 2 diabetic Zucker diabetic fatty rats.

1 reference

12 December 2020

Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus

1 reference

12 December 2020

Nitric oxide release accounts for insulin's vascular effects in humans

1 reference

12 December 2020

Arachidonic acid metabolites as endothelium-derived hyperpolarizing factors

1 reference

12 December 2020

Twenty-four-hour exposure to altered blood flow modifies endothelial Ca2+-activated K+ channels in rat mesenteric arteries

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12 December 2020

Compromised arterial function in human type 2 diabetic patients

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12 December 2020

Coordination of vasomotor responses by the endothelium

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12 December 2020

Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans

1 reference

12 December 2020

Effects of simulated hyperglycemia, insulin, and glucagon on endothelial nitric oxide synthase expression

1 reference

12 December 2020

Effect of tetrahydrobiopterin on endothelial function in canine middle cerebral arteries

1 reference

12 December 2020

Biochemistry and molecular cell biology of diabetic complications

1 reference

12 December 2020

Time-course changes in plasma endothelin-1 and its effects on the mesenteric arterial bed in streptozotocin-induced diabetic rats

1 reference

12 December 2020

Characterisation of glucose transporters in the intact coronary artery endothelium in rats: GLUT-2 upregulated by long-term hyperglycaemia

1 reference

12 December 2020

Effects of intensive glucose lowering in type 2 diabetes

1 reference

12 December 2020

Endothelial Ca+-activated K+ channels in normal and impaired EDHF-dilator responses--relevance to cardiovascular pathologies and drug discovery

1 reference

12 December 2020

Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells

1 reference

12 December 2020

Interactions between nitric oxide and cytochrome P-450 in the liver

1 reference

12 December 2020

Endothelium and control of vascular function. State of the Art lecture

1 reference

12 December 2020

Nitric oxide and peroxynitrite in health and disease

1 reference

12 December 2020

Tetrahydrobiopterin: mediator of endothelial protection

1 reference

12 December 2020

High glucose induces alteration of gap junction permeability and phosphorylation of connexin-43 in cultured aortic smooth muscle cells.

1 reference

12 December 2020

Role of caveolar compartmentation in endothelium-derived hyperpolarizing factor-mediated relaxation: Ca2+ signals and gap junction function are regulated by caveolin in endothelial cells

1 reference

12 December 2020

Circulating markers of endothelial function in cardiovascular disease

1 reference

12 December 2020

Fundamentals of endothelial function for the clinical cardiologist

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12 December 2020

Diabetes reduces aortic endothelial gap junctions in ApoE-deficient mice: simvastatin exacerbates the reduction

1 reference

12 December 2020

Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells

1 reference

12 December 2020

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.

1 reference

12 December 2020

Endothelial-specific deletion of connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion

1 reference

12 December 2020

Pharmacological characteristics of endothelium-derived hyperpolarizing factor-mediated relaxation of small mesenteric arteries from db/db mice

1 reference

12 December 2020

Glucose enhances expression of TRPC1 and calcium entry in endothelial cells

1 reference

12 December 2020

Impaired endothelium-derived hyperpolarizing factor-mediated dilations and increased blood pressure in mice deficient of the intermediate-conductance Ca2+-activated K+ channel.

1 reference

12 December 2020

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1 reference

12 December 2020

Alteration of endothelins: a common pathogenetic mechanism in chronic diabetic complications.

1 reference

12 December 2020

In vivo chromatin remodeling events leading to inflammatory gene transcription under diabetic conditions

1 reference

12 December 2020

Diabetes and advanced glycation endproducts

1 reference

12 December 2020

Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus.

1 reference

12 December 2020

Effects of tetrahydrobiopterin on coronary vascular reactivity in atherosclerotic human coronary arteries.

1 reference

12 December 2020

Tetrahydrobiopterin improves endothelial function in human saphenous veins

1 reference

12 December 2020

Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail

1 reference

12 December 2020

Altered Expression of Small-Conductance Ca2+-Activated K+ (SK3) Channels Modulates Arterial Tone and Blood Pressure

1 reference

12 December 2020

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells

1 reference

12 December 2020

Perivascular adipose tissue as a messenger of the brain-vessel axis: role in vascular inflammation and dysfunction.

1 reference

12 December 2020

TRP proteins: a new dimension in the treatment of occlusive vascular disease

1 reference

12 December 2020

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide

1 reference

12 December 2020

Regulation of intracerebral arteriolar tone by K(v) channels: effects of glucose and PKC.

1 reference

12 December 2020

Enhanced spontaneous Ca2+ events in endothelial cells reflect signalling through myoendothelial gap junctions in pressurized mesenteric arteries

1 reference

12 December 2020

Mechanisms for early microvascular injury in obesity and type II diabetes

1 reference

12 December 2020

Sulfaphenazole treatment restores endothelium-dependent vasodilation in diabetic mice.

1 reference

12 December 2020

Endothelin-1 inhibits endothelium-dependent vasodilatation in the human forearm: reversal by ETA receptor blockade in patients with atherosclerosis

1 reference

12 December 2020

High glucose impairs voltage-gated K(+) channel current in rat small coronary arteries

1 reference

12 December 2020

Glucose reduces endothelin inhibition of voltage-gated potassium channels in rat arterial smooth muscle cells

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12 December 2020

High glucose concentrations dilate cerebral arteries and diminish myogenic tone through an endothelial mechanism

1 reference

12 December 2020

Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes

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12 December 2020

Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner

1 reference

12 December 2020

TRP channels: an overview

1 reference

12 December 2020

DAF-FM (4-amino-5-methylamino-2',7'-difluorofluorescein) diacetate detects impairment of agonist-stimulated nitric oxide synthesis by elevated glucose in human vascular endothelial cells: reversal by vitamin C and L-sepiapterin

1 reference

12 December 2020

Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior

1 reference

12 December 2020

Endothelium-dependent hyperpolarizations: past beliefs and present facts

1 reference

12 December 2020

Microvascular dysfunction after transient high glucose is caused by superoxide-dependent reduction in the bioavailability of NO and BH(4).

1 reference

12 December 2020

Phosphorylation of the leucocyte NADPH oxidase subunit p47(phox) by casein kinase 2: conformation-dependent phosphorylation and modulation of oxidase activity

1 reference

12 December 2020

Inhibitory effect of high concentration of glucose on relaxations to activation of ATP-sensitive K+ channels in human omental artery.

1 reference

12 December 2020

Assessment and treatment of endothelial dysfunction in humans

1 reference

12 December 2020

Glucose-evoked alterations in connexin43-mediated cell-to-cell communication in human collecting duct: a possible role in diabetic nephropathy.

1 reference

12 December 2020

Store-operated calcium entry promotes shape change in pulmonary endothelial cells expressing Trp1

1 reference

12 December 2020

Molecular mechanisms mediating inhibition of human large conductance Ca2+-activated K+ channels by high glucose

1 reference

12 December 2020

The vascular endothelium in diabetes: a practical target for drug treatment?

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12 December 2020

Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells

1 reference

12 December 2020

Twenty-five years since the discovery of endothelium-derived relaxing factor (EDRF): does a dysfunctional endothelium contribute to the development of type 2 diabetes?

1 reference

12 December 2020

High glucose increases expression of cyclooxygenase-2, increases oxidative stress and decreases the generation of nitric oxide in mouse microvessel endothelial cells

1 reference

12 December 2020

Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways

1 reference

12 December 2020

High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells: role of protein kinase C and reactive oxygen species

1 reference

12 December 2020

Induces vasodilatation of rat mesenteric artery in vitro mainly by inhibiting receptor-mediated Ca(2+)-influx and Ca(2+)-release.

1 reference

12 December 2020

The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

1 reference

12 December 2020

Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation

1 reference

12 December 2020

Endothelial function: ready for prime time?

1 reference

12 December 2020

Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis

1 reference

12 December 2020

Tetrahydrobiopterin as an alternative treatment for mild phenylketonuria

1 reference

12 December 2020

Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesis

1 reference

12 December 2020

Hydrogen peroxide inhibits cytochrome p450 epoxygenases: interaction between two endothelium-derived hyperpolarizing factors

1 reference

12 December 2020

Evidence for a functional calcium-sensing receptor that modulates myogenic tone in rat subcutaneous small arteries.

1 reference

12 December 2020

Endothelium-derived hyperpolarizing factor in vascular physiology and cardiovascular disease

1 reference

12 December 2020

Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice

1 reference

12 December 2020

Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in essential hypertensive patients

1 reference

12 December 2020

Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice

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12 December 2020

Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

1 reference

12 December 2020

Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS-/-) and eNOS-expressing (eNOS+/+) mice

1 reference

12 December 2020

Dual modulation of vascular function by perivascular adipose tissue and its potential correlation with adiposity/lipoatrophy-related vascular dysfunction

1 reference

12 December 2020

Functional architecture of inositol 1,4,5-trisphosphate signaling in restricted spaces of myoendothelial projections

1 reference

12 December 2020

The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes

1 reference

12 December 2020

Active and passive mechanical properties of isolated arterioles from STZ-induced diabetic rats. Effect of aminoguanidine treatment

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12 December 2020

What's where and why at a vascular myoendothelial microdomain signalling complex.

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12 December 2020

Impaired small-conductance Ca2+-activated K+ channel-dependent EDHF responses in Type II diabetic ZDF rats

1 reference

12 December 2020

5-Methyltetrahydrofolate and tetrahydrobiopterin can modulate electrotonically mediated endothelium-dependent vascular relaxation.

1 reference

12 December 2020

Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity

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12 December 2020

Endothelium-derived relaxing factors: a focus on endothelium-derived hyperpolarizing factor(s).

1 reference

12 December 2020

Characterization of endothelium-derived hyperpolarizing factor in the human forearm microcirculation

1 reference

12 December 2020

Spatial separation of endothelial small- and intermediate-conductance calcium-activated potassium channels (K(Ca)) and connexins: possible relationship to vasodilator function?

1 reference

12 December 2020

Structure and function of small arteries

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12 December 2020

Intestinal glucose sensing and regulation of intestinal glucose absorption.

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12 December 2020

ROS-sensitive cytochrome P450 activity maintains endothelial dilatation in ageing but is transitory in dyslipidaemic mice.

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12 December 2020

BK channels in cardiovascular disease: a complex story of channel dysregulation

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12 December 2020

Calcium channels, stores, and oscillations

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12 December 2020

Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells

1 reference

12 December 2020

Evidence for Involvement of Both IK Ca and SK Ca Channels in Hyperpolarizing Responses of the Rat Middle Cerebral Artery

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12 December 2020

Prognostic value of coronary vascular endothelial dysfunction

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12 December 2020

Ion channels in vascular endothelium

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12 December 2020

Downregulation of connexin 43 expression by high glucose reduces gap junction activity in microvascular endothelial cells.

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12 December 2020

Store depletion and calcium influx

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12 December 2020

Calpain activation contributes to hyperglycaemia-induced apoptosis in cardiomyocytes.

1 reference

12 December 2020

Prevention Conference VI: Diabetes and Cardiovascular Disease: executive summary: conference proceeding for healthcare professionals from a special writing group of the American Heart Association

1 reference

12 December 2020

Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid.

1 reference

12 December 2020

Differential effects of glucose on agonist-induced relaxations in human mesenteric and subcutaneous arteries

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12 December 2020

Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia

1 reference

12 December 2020

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

1 reference

12 December 2020

Diabetes downregulates large-conductance Ca2+-activated potassium beta 1 channel subunit in retinal arteriolar smooth muscle

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12 December 2020

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease

1 reference

12 December 2020

Regulation of tetrahydrobiopterin biosynthesis by shear stress

1 reference

12 December 2020

Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231.

1 reference

12 December 2020

Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease

1 reference

12 December 2020

Downregulation of connexin40 is associated with coronary endothelial cell dysfunction in streptozotocin-induced diabetic mice

1 reference

12 December 2020

Small- and intermediate-conductance calcium-activated K+ channels provide different facets of endothelium-dependent hyperpolarization in rat mesenteric artery

1 reference

12 December 2020

A unifying view of ageing and disease: the double-agent theory

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12 December 2020

Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion

1 reference

12 December 2020

Vascular dysfunction in type 2 diabetic TallyHo mice: role for an increase in the contribution of PGH2/TxA2 receptor activation and cytochrome p450 products

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12 December 2020

Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo

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12 December 2020

Close relation of endothelial function in the human coronary and peripheral circulations

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12 December 2020

10.1007/S00424-010-0807-3

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20238124