Natural products and their biological targets: proteomic and metabolomic labeling strategies (Q37718098)

22 August 2017

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title

Natural products and their biological targets: proteomic and metabolomic labeling strategies (English)

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22 August 2017

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Thomas Böttcher

1

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22 August 2017

Maximilian Pitscheider

series ordinal

2

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22 August 2017

Stephan A Sieber

series ordinal

3

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22 August 2017

language of work or name

English

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publication date

1 April 2010

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Angewandte Chemie International Edition

22 August 2017

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volume

49

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22 August 2017

2680-2698

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22 August 2017

15

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Assignment of protein function in the postgenomic era.

22 August 2017

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Proteomics to study genes and genomes

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Monitoring gene expression using DNA microarrays

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Multidimensional separations-based shotgun proteomics

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Mass spectrometry-based proteomics

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Activity-based probes as a tool for functional proteomic analysis of proteases.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Mechanism-based profiling of enzyme families

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Activity-based protein profiling: from enzyme chemistry to proteomic chemistry

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Activity based probes for proteases: applications to biomarker discovery, molecular imaging and drug screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

The application of a novel biotinylated affinity label for the detection of a cathepsin B-like precursor produced by breast-tumour cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Fluorescent derivatives of diphenyl [1-(N-peptidylamino)alkyl]phosphonate esters: synthesis and use in the inhibition and cellular localization of serine proteases

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Protein-reactive natural products

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Global strategies to integrate the proteome and metabolome

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Discovery metabolite profiling--forging functional connections between the proteome and metabolome

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Activity-based protein profiling: the serine hydrolases

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Profiling serine hydrolase activities in complex proteomes

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Irreversible inhibitors of serine, cysteine, and threonine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Enzyme activity--it's all about image

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Cell surface engineering by a modified Staudinger reaction

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Chemoselective ligation and modification strategies for peptides and proteins.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Bioorthogonal chemistry: fishing for selectivity in a sea of functionality

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

The Staudinger ligation-a gift to chemical biology.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Profiling enzyme activities in vivo using click chemistry methods

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Copper-free click chemistry for dynamic in vivo imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Mapping enzyme active sites in complex proteomes

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

A tandem orthogonal proteolysis strategy for high-content chemical proteomics

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

A streamlined platform for high-content functional proteomics of primary human specimens

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Discovering disease-associated enzymes by proteome reactivity profiling

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Disparate proteome reactivity profiles of carbon electrophiles

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Cinnamic aldehyde derived probes for the active site labelling of pathogenesis associated enzymes.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Vinyl sulfones as mechanism-based cysteine protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Comparative behaviour of calpain and cathepsin B toward peptidyl acyloxymethyl ketones, sulphonium methyl ketones and other potential inhibitors of cysteine proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Proteomics evaluation of chemically cleavable activity-based probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Aryl Vinyl Sulfonates and Sulfones as Active Site-Directed and Mechanism-Based Probes for Protein Tyrosine Phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Activity-based probes for the proteomic profiling of metalloproteases

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Proteomic profiling of metalloprotease activities with cocktails of active-site probes

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Inhibitor fingerprinting of matrix metalloproteases using a combinatorial peptide hydroxamate library

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Chemical proteomics and its application to drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Activity-based proteomics: enzyme chemistry redux

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Chemical strategies for activity-based proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Natural products in drug discovery and development

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

The influence of natural products upon drug discovery

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Natural products as sources of new drugs over the period 1981-2002.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Synthesis and function of 3-phosphorylated inositol lipids

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

A cell-permeable, activity-based probe for protein and lipid kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Design and synthesis of AX7574: a microcystin-derived, fluorescent probe for serine/threonine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

The structure of showdomycin, a novel carbon-linked nucleoside antibiotic related to uridine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Structural Analysis of Spiro β-Lactone Proteasome Inhibitors

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Penicillin-binding proteins and beta-lactam resistance

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Biological characterization of a new radioactive labeling reagent for bacterial penicillin-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Beta-lactams as selective chemical probes for the in vivo labeling of bacterial enzymes involved in cell wall biosynthesis, antibiotic resistance, and virulence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Beta-lactam probes as selective chemical-proteomic tools for the identification and functional characterization of resistance associated enzymes in MRSA.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Phosphoglycerate mutase-derived polypeptide inhibits glycolytic flux and induces cell growth arrest in tumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Chemical approaches for functionally probing the proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Beta-lactones decrease the intracellular virulence of Listeria monocytogenes in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Proteases of malaria parasites: new targets for chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

A role for the protease falcipain 1 in host cell invasion by the human malaria parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Global regulatory impact of ClpP protease of Staphylococcus aureus on regulons involved in virulence, oxidative stress response, autolysis, and DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Structurally refined beta-lactones as potent inhibitors of devastating bacterial virulence factors.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Assignment of endogenous substrates to enzymes by global metabolite profiling

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Metabolomics approach for enzyme discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Metabolomics reviewed: a new "omics" platform technology for systems biology and implications for natural products research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

The expanding role of mass spectrometry in metabolite profiling and characterization

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Molecular phenotyping of the pal1 and pal2 mutants of Arabidopsis thaliana reveals far-reaching consequences on phenylpropanoid, amino acid, and carbohydrate metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

A FAAH-regulated class of N-acyl taurines that activates TRP ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

A brain detoxifying enzyme for organophosphorus nerve poisons

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Peptidase substrates via global peptide profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Elucidation of gene-to-gene and metabolite-to-gene networks in arabidopsis by integration of metabolomics and transcriptomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Comparative assessment of large-scale proteomic studies of apoptotic proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Global mapping of the topography and magnitude of proteolytic events in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

A global metabolite profiling approach to identify protein-metabolite interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

Enrichment tags for enhanced-resolution profiling of the polar metabolome

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.200905352

Microarray platform for profiling enzyme activities in complex proteomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.200905352

21 January 2018

Identifiers

DOI

10.1002/ANIE.200905352

1 reference

22 August 2017

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