HS-173, a novel PI3K inhibitor suppresses EMT and metastasis in pancreatic cancer (Q37718484)

22 August 2017

HS-173, a novel PI3K inhibitor suppresses EMT and metastasis in pancreatic cancer (English)

1 reference

22 August 2017

1 reference

10

Sungwoo Hong

1 reference

22 August 2017

Marufa Rumman

1

1 reference

22 August 2017

Kyung Hee Jung

2

1 reference

22 August 2017

Zhenghuan Fang

3

1 reference

22 August 2017

Hong Hua Yan

4

1 reference

22 August 2017

Mi Kwon Son

5

1 reference

22 August 2017

Soo Jung Kim

6

1 reference

22 August 2017

Juyoung Kim

7

1 reference

22 August 2017

Jung Hee Park

8

1 reference

22 August 2017

Joo Han Lim

9

1 reference

22 August 2017

Soon-Sun Hong

11

1 reference

22 August 2017

language of work or name

English

0 references

publication date

25 October 2016

1 reference

22 August 2017

1 reference

22 August 2017

7

1 reference

22 August 2017

47

1 reference

22 August 2017

78029-78047

1 reference

describes a project that uses

22 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5363641/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors

23 August 2017

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Loss of E-cadherin and epithelial to mesenchymal transition is not required for cell motility in tissues or for metastasis

23 August 2017

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Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model

23 August 2017

1 reference

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Anoikis resistance: an essential prerequisite for tumor metastasis

23 August 2017

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TWIST and p-Akt immunoexpression in normal oral epithelium, oral dysplasia and in oral squamous cell carcinoma.

23 August 2017

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23 August 2017

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Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion

23 August 2017

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Pancreatic cancer stem cells and EMT in drug resistance and metastasis.

23 August 2017

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Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer

23 August 2017

1 reference

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Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

23 August 2017

1 reference

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Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells

23 August 2017

1 reference

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E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer

23 August 2017

1 reference

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Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

23 August 2017

1 reference

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Metastatic pancreatic cancer 2008: is the glass less empty?

23 August 2017

1 reference

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Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis

23 August 2017

1 reference

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Intra-operative rapid diagnostic method based on CK19 mRNA expression for the detection of lymph node metastases in breast cancer

23 August 2017

1 reference

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Epithelial-mesenchymal transition in ovarian cancer progression: a crucial role for the endothelin axis

23 August 2017

1 reference

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Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

23 August 2017

1 reference

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Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer

23 August 2017

1 reference

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The neuropsychological correlates of borderline personality disorder and suicidal behaviour

23 August 2017

1 reference

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Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways

23 August 2017

1 reference

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The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFbeta signal transduction

23 August 2017

1 reference

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Dual role of transforming growth factor beta in mammary tumorigenesis and metastatic progression.

23 August 2017

1 reference

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Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

23 August 2017

1 reference

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TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

23 August 2017

1 reference

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Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

23 August 2017

1 reference

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ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types

23 August 2017

1 reference

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Epithelial-mesenchymal transition in pancreatic cancer: Is it a clinically significant factor?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5363641

Osthole inhibits insulin-like growth factor-1-induced epithelial to mesenchymal transition via the inhibition of PI3K/Akt signaling pathway in human brain cancer cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5363641

Role of aberrant PI3K pathway activation in gallbladder tumorigenesis

6 September 2017

1 reference

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The dual PI3K/mTOR inhibitor NVP-BEZ235 prevents epithelial-mesenchymal transition induced by hypoxia and TGF-β1.

6 September 2017

1 reference

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Epithelial-to-mesenchymal transition rewires the molecular path to PI3K-dependent proliferation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5363641

A novel imidazopyridine PI3K inhibitor with anticancer activity in non-small cell lung cancer cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5363641

Synergistic anticancer activity of HS-173, a novel PI3K inhibitor in combination with Sorafenib against pancreatic cancer cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5363641

HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5363641

PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5363641

The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5363641

TGF-β2 induces epithelial-mesenchymal transition in cultured human lens epithelial cells through activation of the PI3K/Akt/mTOR signaling pathway

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5363641

Epithelial-mesenchymal transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancer

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5363641

Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5363641

Solitary cell infiltration is a novel indicator of poor prognosis and epithelial-mesenchymal transition in pancreatic cancer

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5363641

Cytokeratin-19 mRNA-positive circulating tumor cells after adjuvant chemotherapy in patients with early breast cancer.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5363641

Epithelial to mesenchymal transition: expression of the regulators snail, slug, and twist in pancreatic cancer.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5363641

TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5363641

Inhibition of tumor growth and vasculogenic mimicry by curcumin through down-regulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma model

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27793006

12 December 2020

inferred from PubMed ID database lookup

Molecular quantification and mapping of lymph-node micrometastases in cervical cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27793006

12 December 2020

inferred from PubMed ID database lookup

A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27793006

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.18632/ONCOTARGET.12871

1 reference

release_sjmehrdbqnbmlhp3hwtdw4lfp4

22 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/sjmehrdbqnbmlhp3hwtdw4lfp4

24 November 2022

mapped directly with Wikidata item

1 reference

22 August 2017

PubMed publication ID

27793006

1 reference