Assessing TP53 status in human tumours to evaluate clinical outcome (Q34570100)

3 August 2017

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title

Assessing TP53 status in human tumours to evaluate clinical outcome (English)

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3 August 2017

C Béroud

2

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author name string

T Soussi

series ordinal

1

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3 August 2017

language of work or name

English

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publication date

1 December 2001

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3 August 2017

Nature Reviews Cancer

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3 August 2017

1

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3 August 2017

3

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3 August 2017

233-240

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https://scigraph.springernature.com/pub.10.1038/35106009

3 August 2017

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21 January 2018

Surfing the p53 network

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Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

21 January 2018

1 reference

Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

1 reference

Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumours

21 January 2018

1 reference

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

21 January 2018

1 reference

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

21 January 2018

1 reference

ATM: a mediator of multiple responses to genotoxic stress

21 January 2018

1 reference

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

21 January 2018

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p53: a frequent target for genetic abnormalities in lung cancer.

21 January 2018

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Mutations in the p53 gene occur in diverse human tumour types

21 January 2018

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Characterization of germline TP53 splicing mutations and their genetic and functional analysis

21 January 2018

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Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma

21 January 2018

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Lack of prognostic significance of p53 and K-ras mutations in primary resected non-small-cell lung cancer on E4592: a Laboratory Ancillary Study on an Eastern Cooperative Oncology Group Prospective Randomized Trial of Postoperative Adjuvant Therapy

21 January 2018

1 reference

The molecular epidemiology of p53 gene mutations in human breast cancer

21 January 2018

1 reference

Definition of a consensus binding site for p53

21 January 2018

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Oncogenic forms of p53 inhibit p53-regulated gene expression

21 January 2018

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Gain of function mutations in p53.

21 January 2018

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

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Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

21 January 2018

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Hot-spot mutants of p53 core domain evince characteristic local structural changes.

21 January 2018

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Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer

21 January 2018

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TP53 mutations and breast cancer prognosis: particularly poor survival rates for cases with mutations in the zinc-binding domains.

21 January 2018

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High metastatic potential in mice inheriting a targeted p53 missense mutation

21 January 2018

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Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions.

21 January 2018

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P63 and P73: P53 mimics, menaces and more

21 January 2018

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p53 family genes: structural comparison, expression and mutation

21 January 2018

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Structure, function and regulation of p63 and p73.

21 January 2018

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AIS is an oncogene amplified in squamous cell carcinoma

21 January 2018

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A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

21 January 2018

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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

21 January 2018

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The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

21 January 2018

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p53 associates with and targets Delta Np63 into a protein degradation pathway

21 January 2018

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Role of a p53 polymorphism in the development of human papillomavirus-associated cancer.

21 January 2018

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p53 codon 72 polymorphism and risk of cervical cancer in UK.

21 January 2018

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Rapid p53 sequence analysis in primary lung cancer using an oligonucleotide probe array

21 January 2018

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Rescuing the function of mutant p53.

21 January 2018

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NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

21 January 2018

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Identification and classification of p53-regulated genes

21 January 2018

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Isolation and characterization of sixteen novel p53 response genes.

21 January 2018

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DNA microarrays identification of primary and secondary target genes regulated by p53.

21 January 2018

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The role of p53-target genes in human cancer

21 January 2018

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p53; from inductive signal to cellular effect

21 January 2018

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Twenty years of p53 research: structural and functional aspects of the p53 protein

21 January 2018

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Association of p53 accumulation with TP53 mutations, loss of heterozygosity at 17p13, and DNA ploidy status in 273 colorectal carcinomas.

21 January 2018

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Mutations in exon 7 and 8 of p53 as poor prognostic factors in patients with non-small cell lung cancer

21 January 2018

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p53 exon 5 mutations as a prognostic indicator of shortened survival in non-small-cell lung cancer

21 January 2018

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Mutations in zinc-binding domains of p53 as a prognostic marker of esophageal-cancer patients.

21 January 2018

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Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

21 January 2018

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p53 polymorphism and risk of cervical cancer

21 January 2018

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p53 Website and analysis of p53 gene mutations in human cancer: Forging a link between epidemiology and carcinogenesis

21 January 2018

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7 January 2021

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

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7 January 2021

Different tumor-derived p53 mutants exhibit distinct biological activities

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7 January 2021

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice

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7 January 2021

Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

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7 January 2021

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

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7 January 2021

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

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7 January 2021

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

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7 January 2021

Prognostic significance of mutations in the p53 gene, particularly in the zinc-binding domains, in lymph node- and steroid receptor positive breast cancer patients

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7 January 2021

Prognostic significance ofp53 mutation in breast cancer: Frequent detection of non-missense mutations by yeast functional assay

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7 January 2021

p53 mutation as a genetic trait of typical medullary breast carcinoma

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7 January 2021

Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

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7 January 2021

p53 polymorphism and risk of cervical cancer

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7 January 2021

Is p53 polymorphism maintained by natural selection?

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7 January 2021

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

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7 January 2021

Distinct prognostic values of p53 mutations and loss of estrogen receptor and their cumulative effect in primary breast cancers

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7 January 2021

p53 and survival in early onset breast cancer: analysis of gene mutations, loss of heterozygosity and protein accumulation

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7 January 2021

TP53 DNA contact mutations are selectively associated with allelic loss and have a strong clinical impact in head and neck cancer

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7 January 2021

Identifiers

DOI

10.1038/35106009

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Dimensions Publication ID

3 August 2017

1023694803

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Fatcat ID

release_oflfzrl3frhh3i645izrj2ddv4

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Fatcat

https://api.fatcat.wiki/v0/release/oflfzrl3frhh3i645izrj2ddv4

24 November 2022

mapped directly with Wikidata item

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