Mitochondrial proteomics as a selective tool for unraveling Parkinson's disease pathogenesis (Q37727186)

22 August 2017

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title

Mitochondrial proteomics as a selective tool for unraveling Parkinson's disease pathogenesis (English)

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22 August 2017

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Ilse Sanet Pienaar

1

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22 August 2017

David Trevor Dexter

series ordinal

2

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22 August 2017

Pierre Roland Burkhard

series ordinal

3

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22 August 2017

publication date

1 April 2010

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Expert Review of Proteomics

22 August 2017

published in

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22 August 2017

volume

7

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22 August 2017

issue

2

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22 August 2017

page(s)

205-226

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Staging of brain pathology related to sporadic Parkinson's disease

22 August 2017

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Evidence that the blockade of mitochondrial respiration by the neurotoxin 1-methyl-4-phenylpyridinium (MPP+) involves binding at the same site as the respiratory inhibitor, rotenone

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Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

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Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

21 January 2018

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Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

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Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism

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Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

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Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats

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Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

21 January 2018

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Rotenone induces cell death in primary dopaminergic culture by increasing ROS production and inhibiting mitochondrial respiration

21 January 2018

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Unaltered aconitase activity, but decreased complex I activity in substantia nigra pars compacta of patients with Parkinson's disease

21 January 2018

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Mitochondrial involvement in Parkinson's disease

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Mitochondrial complex I deficiency in Parkinson's disease

21 January 2018

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Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled.

21 January 2018

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Biochemical analysis of cybrids expressing mitochondrial DNA from Contursi kindred Parkinson's subjects

21 January 2018

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Mitochondrial complex I, II/III, and IV activities in familial and sporadic Parkinson's disease

21 January 2018

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Mitochondrial complex I and II activities of lymphocytes and platelets in Parkinson's disease

21 January 2018

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Respiratory-chain enzyme activities in isolated mitochondria of lymphocytes from patients with Parkinson's disease: preliminary study

21 January 2018

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Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease

21 January 2018

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Role of mitochondria in oxidative stress and aging

21 January 2018

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Mitochondrial protein oxidation and degradation in response to oxidative stress and aging

21 January 2018

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Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease

21 January 2018

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Mitochondrial DNA polymorphisms as risk factors for Parkinson's disease and Parkinson's disease dementia

21 January 2018

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Genotype in the 24-kDa subunit gene (NDUFV2) of mitochondrial complex I and susceptibility to Parkinson disease

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

21 January 2018

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Early-onset familial parkinsonism due to POLG mutations.

21 January 2018

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Two novel POLG1 mutations in a patient with progressive external ophthalmoplegia, levodopa-responsive pseudo-orthostatic tremor and parkinsonism

21 January 2018

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Clinical and genetic heterogeneity in progressive external ophthalmoplegia due to mutations in polymerase gamma

21 January 2018

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

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Tickled PINK1: mitochondrial homeostasis and autophagy in recessive Parkinsonism.

21 January 2018

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Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

21 January 2018

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Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

21 January 2018

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Update on the genetics of Parkinson's disease

21 January 2018

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Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

21 January 2018

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Mitochondrial ND5 mutations in idiopathic Parkinson's disease

21 January 2018

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Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

21 January 2018

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Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

21 January 2018

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Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls

21 January 2018

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Genetic variation of Omi/HtrA2 and Parkinson's disease

21 January 2018

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Mechanisms of impaired mitochondrial energy metabolism in acute and chronic neurodegenerative disorders

21 January 2018

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Clinically approved heterocyclics act on a mitochondrial target and reduce stroke-induced pathology.

21 January 2018

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Promethazine protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.

21 January 2018

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Progress on the mitochondrial permeability transition pore: regulation by complex I and ubiquinone analogs.

21 January 2018

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The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

21 January 2018

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Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart.

21 January 2018

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The effects of focal ischemia and reperfusion on the glutathione content of mitochondria from rat brain subregions

21 January 2018

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VDAC2 inhibits BAK activation and mitochondrial apoptosis

21 January 2018

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The voltage-dependent anion channel (VDAC): function in intracellular signalling, cell life and cell death.

21 January 2018

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The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria.

21 January 2018

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Species- and tissue-specific relationships between mitochondrial permeability transition and generation of ROS in brain and liver mitochondria of rats and mice.

21 January 2018

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Dynamics of intracellular calcium and free radical production during ischemia in pyramidal neurons.

21 January 2018

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Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore.

21 January 2018

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The proteomics of neurodegeneration

21 January 2018

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Neuroproteomics as a promising tool in Parkinson's disease research

21 January 2018

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Applied proteomics: mitochondrial proteins and effect on function

21 January 2018

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Proteome analysis of human substantia nigra in Parkinson's disease.

21 January 2018

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Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia

21 January 2018

1 reference

Oxidative stress and 17-alpha- and 17-beta-estradiol modulate neurofilaments differently

21 January 2018

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Proteome analysis of human substantia nigra in Parkinson's disease

21 January 2018

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Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function

21 January 2018

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Parkin-associated Parkinson's disease

21 January 2018

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Mitochondrial dysfunction, oxidative stress, and apoptosis revealed by proteomic and transcriptomic analyses of the striata in two mouse models of Parkinson's disease

21 January 2018

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Long-term consequences of methamphetamine exposure in young adults are exacerbated in glial cell line-derived neurotrophic factor heterozygous mice.

21 January 2018

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Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions

21 January 2018

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Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage

21 January 2018

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ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia

21 January 2018

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Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis

21 January 2018

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Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease

21 January 2018

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Increased flexibility and selectivity in spatial learning of transgenic mice ectopically expressing the neural cell adhesion molecule L1 in astrocytes.

21 January 2018

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L1 neural cell adhesion molecule is a survival factor for fetal dopaminergic neurons

21 January 2018

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Proteome analysis of ventral midbrain in MPTP-treated normal and L1cam transgenic mice

21 January 2018

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A proteomic approach in the study of an animal model of Parkinson's disease.

21 January 2018

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Proteomics analysis provides insight into caloric restriction mediated oxidation and expression of brain proteins associated with age-related impaired cellular processes: Mitochondrial dysfunction, glutamate dysregulation and impaired protein synthe

21 January 2018

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Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B

21 January 2018

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Monoamine oxidase activity and monoamine metabolism in brains of parkinsonian patients treated with l-deprenyl

21 January 2018

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Monoamine oxidase-inhibition and MPTP-induced neurotoxicity in the non-human primate: comparison of rasagiline (TVP 1012) with selegiline

21 January 2018

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Neuroprotective effect of rasagiline in a rodent model of Parkinson's disease

21 January 2018

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A double-blind, delayed-start trial of rasagiline in Parkinson's disease

21 January 2018

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The anti-Parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells

21 January 2018

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An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic bcl-2 in human dopaminergic SH-SY5Y cells

21 January 2018

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Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol

21 January 2018

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Contrasting neuroprotective and neurotoxic actions of respective metabolites of anti-Parkinson drugs rasagiline and selegiline

21 January 2018

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Further evidence that amphetamines produce long-lasting dopamine neurochemical deficits by destroying dopamine nerve fibers

21 January 2018

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Why is parkinsonism not a feature of human methamphetamine users?

21 January 2018

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Neuroprotective and neurotoxic effects of monoamine oxidase-B inhibitors and derived metabolites under ischemia in PC12 cells

21 January 2018

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Neuroprotection by monoamine oxidase B inhibitors: a therapeutic strategy for Parkinson's disease?

21 January 2018

1 reference

Genomic and proteomic study to survey the mechanism of action of the anti-Parkinson's disease drug, rasagiline compared with selegiline, in the rat midbrain.

21 January 2018

1 reference

Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: new insights and implications for therapy

21 January 2018

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N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor

21 January 2018

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Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease

21 January 2018

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Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra

21 January 2018

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The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling

21 January 2018

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Absence of inclusion body formation in the MPTP mouse model of Parkinson's disease

21 January 2018

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Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson's disease

21 January 2018

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Modelling Parkinson-like neurodegeneration via osmotic minipump delivery of MPTP and probenecid

21 January 2018

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Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

21 January 2018

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Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes

21 January 2018

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Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease

21 January 2018

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Proteomic analysis of rat brain mitochondria following exposure to dopamine quinone: implications for Parkinson disease.

21 January 2018

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Inhibition of cytosolic and mitochondrial creatine kinase by siRNA in HaCaT- and HeLaS3-cells affects cell viability and mitochondrial morphology

21 January 2018

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Octameric mitochondrial creatine kinase induces and stabilizes contact sites between the inner and outer membrane

21 January 2018

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Mitochondrial creatine kinase in contact sites: interaction with porin and adenine nucleotide translocase, role in permeability transition and sensitivity to oxidative damage

21 January 2018

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Differential effects of peroxynitrite on human mitochondrial creatine kinase isoenzymes. Inactivation, octamer destabilization, and identification of involved residues

21 January 2018

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Mitochondrial import driving forces: enhanced trapping by matrix Hsp70 stimulates translocation and reduces the membrane potential dependence of loosely folded preproteins

21 January 2018

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The mitochondrial inner membrane protein mitofilin controls cristae morphology

21 January 2018

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The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11

21 January 2018

1 reference

Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease.

21 January 2018

1 reference

Analysis of alpha-synuclein-associated proteins by quantitative proteomics

21 January 2018

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Microglial activation induced by neurodegeneration: a proteomic analysis

21 January 2018

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Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

21 January 2018

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Quantitative protein profiling by mass spectrometry using isotope-coded affinity tags

21 January 2018

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The role of alpha-synuclein in Parkinson's disease: insights from animal models

21 January 2018

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A Drosophila model of Parkinson's disease

21 January 2018

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Protein expression in a Drosophila model of Parkinson's disease

21 January 2018

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Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease

21 January 2018

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Global internal standard technology for comparative proteomics

21 January 2018

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Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice--a model of familial Parkinson's disease

21 January 2018

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

21 January 2018

1 reference

Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

21 January 2018

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Conformational behavior of human alpha-synuclein is modulated by familial Parkinson's disease point mutations A30P and A53T.

21 January 2018

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Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

21 January 2018

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Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

21 January 2018

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Enzymes of glycolysis are functionally associated with the mitochondrion in Arabidopsis cells.

21 January 2018

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Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles

21 January 2018

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Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

21 January 2018

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Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways.

21 January 2018

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Parkin enhances mitochondrial biogenesis in proliferating cells

21 January 2018

1 reference

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

Proteomic analysis of parkin knockout mice: alterations in energy metabolism, protein handling and synaptic function

21 January 2018

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Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

21 January 2018

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Stable isotope labeling and label-free proteomics of Drosophila parkin null mutants

21 January 2018

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Identification and relative quantitation of protein mixtures by enzymatic digestion followed by capillary reversed-phase liquid chromatography-tandem mass spectrometry

21 January 2018

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Evolutionary conservation of biogenesis of beta-barrel membrane proteins

21 January 2018

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Evolutionary conservation of the 14-3-3 protein

21 January 2018

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Isolation and functional analysis of mitochondria from the nematode Caenorhabditis elegans

21 January 2018

1 reference

KEGG: kyoto encyclopedia of genes and genomes

21 January 2018

1 reference

The human mitochondrial proteome: oxidative stress, protein modifications and oxidative phosphorylation

21 January 2018

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Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice

21 January 2018

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Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice

21 January 2018

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A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

21 January 2018

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Replication and transcription of mammalian mitochondrial DNA.

21 January 2018

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A genetic approach to identifying mitochondrial proteins

21 January 2018

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The role of separation science in proteomics research

21 January 2018

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Reference map of the low molecular mass proteins of Haemophilus influenzae

21 January 2018

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MitoMiner, an integrated database for the storage and analysis of mitochondrial proteomics data

21 January 2018

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Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders

21 January 2018

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Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism

21 January 2018

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

21 January 2018

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Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline

21 January 2018

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The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease

21 January 2018

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Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

21 January 2018

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A heterozygous effect for PINK1 mutations in Parkinson's disease?

21 January 2018

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Functional aspects of the X-ray structure of mitochondrial creatine kinase: a molecular physiology approach

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/EPR.10.8

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22 August 2017

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