Engineering mammalian cells in bioprocessing - current achievements and future perspectives (Q37730868)

22 August 2017

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title

Engineering mammalian cells in bioprocessing - current achievements and future perspectives (English)

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22 August 2017

Yiping Lim

1

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22 August 2017

Niki S C Wong

2

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22 August 2017

Yih Yean Lee

3

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22 August 2017

Sebastian C Y Ku

4

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22 August 2017

Danny C F Wong

5

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22 August 2017

Miranda G S Yap

6

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22 August 2017

publication date

7 April 2010

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Biotechnology and Applied Biochemistry

22 August 2017

published in

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22 August 2017

volume

55

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22 August 2017

issue

4

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22 August 2017

page(s)

175-189

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Biopharmaceutical benchmarks 2006.

22 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Production of recombinant protein therapeutics in cultivated mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Growth inhibition in animal cell culture. The effect of lactate and ammonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Engineering of a mammalian cell line for reduction of lactate formation and high monoclonal antibody production

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Expression of recombinant cytoplasmic yeast pyruvate carboxylase for the improvement of the production of human erythropoietin by recombinant BHK-21 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Impact of temperature reduction and expression of yeast pyruvate carboxylase on hGM-CSF-producing CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Improving glucose and glutamine metabolism of human HEK 293 and Trichoplusia ni insect cells engineered to express a cytosolic pyruvate carboxylase enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Variation of stoichiometric ratios and their correlation for monitoring and control of animal cell cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

High level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Modification of glucose and glutamine metabolism in hybridoma cells through metabolic engineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Engineering cell metabolism for high-density cell culture via manipulation of sugar transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Amino acid transporters: roles in amino acid sensing and signalling in animal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

A novel cytostatic process enhances the productivity of Chinese hamster ovary cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Controlled proliferation by multigene metabolic engineering enhances the productivity of Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Interferon regulatory factor 1 (IRF-1) mediates cell growth inhibition by transactivation of downstream target genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Regulation of cell growth by IRF-1 in BHK-21 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Metabolic changes during cell growth inhibition by p27 overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Manipulation of culture conditions for BHK cell growth inhibition by IRF-1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Enhanced productivity during controlled proliferation of BHK cells in continuously perfused bioreactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Rat gene encoding the 78-kDa glucose-regulated protein GRP78: its regulatory sequences and the effect of protein glycosylation on its expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Comparative proteomic analysis of GS-NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Functional proteomic analysis of GS-NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Molecular portrait of high productivity in recombinant NS0 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Transcriptional profiling of gene expression changes in a PACE-transfected CHO DUKX cell line secreting high levels of rhBMP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Relationship between recombinant activated protein C secretion rates and mRNA levels in baby hamster kidney cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Molecular definition of predictive indicators of stable protein expression in recombinant NS0 myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Effects of overexpression of X-box binding protein 1 on recombinant protein production in Chinese hamster ovary and NS0 myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Effect of doxycycline-regulated protein disulfide isomerase expression on the specific productivity of recombinant CHO cells: thrombopoietin and antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Increasing the secretory capacity of Saccharomyces cerevisiae for production of single-chain antibody fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Protein disulfide isomerase, but not binding protein, overexpression enhances secretion of a non-disulfide-bonded protein in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Cooverexpression of chaperones for enhanced secretion of a single-chain antibody fragment in Pichia pastoris.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

PDI improves secretion of redox-inactive beta-glucosidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Coexpression of molecular chaperone BiP improves immunoglobulin solubility and IgG secretion from Trichoplusia ni insect cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Effect of increased expression of protein disulfide isomerase and heavy chain binding protein on antibody secretion in a recombinant CHO cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Effect of doxycycline-regulated ERp57 expression on specific thrombopoietin productivity of recombinant CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Effect of PDI overexpression on recombinant protein secretion in CHO cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Effect of doxycycline-regulated calnexin and calreticulin expression on specific thrombopoietin productivity of recombinant Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Xbp1-based engineering of secretory capacity enhances the productivity of Chinese hamster ovary cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Production of recombinant human factor VIII in different cell lines and the effect of human XBP1 co-expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Improved production of recombinant human antithrombin III in Chinese hamster ovary cells by ATF4 overexpression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

The unfolded protein response in nutrient sensing and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Regulation of XBP-1 signaling during transient and stable recombinant protein production in CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Molecular engineering of exocytic vesicle traffic enhances the productivity of Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Life and death in mammalian cell culture: strategies for apoptosis inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Apoptosis in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Animal cell cultures: recent achievements and perspectives in the production of biopharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

The BCL-2 protein family: opposing activities that mediate cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

In hybridoma cultures, deprivation of any single amino acid leads to apoptotic death, which is suppressed by the expression of the bcl-2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Prevention of hybridoma cell death by bcl-2 during suboptimal culture conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Effect of bcl-2 expression on hybridoma cell growth in serum-supplemented, protein-free and diluted media

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Influence of bcl-2 on antibody productivity in high cell density perfusion cultures of hybridoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Co-expression of bcl-2 and bag-1, apoptosis suppressing genes, prolonged viable culture period of hybridoma and enhanced antibody production

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Variable functions of bcl-2 in mediating bioreactor stress- induced apoptosis in hybridoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Glycosylation of an immunoglobulin produced from a murine hybridoma cell line: the effect of culture mode and the anti-apoptotic gene, bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Prolongation of murine hybridoma cell survival in stationary batch culture by Bcl-xL expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Inducible expression of Bcl-XL restricts apoptosis resistance to the antibody secretion phase in hybridoma cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Bcl-2 mediated suppression of apoptosis in myeloma NS0 cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Effect of Bcl-2 overexpression on cell cycle and antibody productivity in chemostat cultures of myeloma NS0 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Suppression of apoptosis in perfusion culture of Myeloma NS0 cells enhances cell growth but reduces antibody productivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Part II. Overexpression of bcl-2 family members enhances survival of mammalian cells in response to various culture insults.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Response of recombinant Chinese hamster ovary cells to hyperosmotic pressure: effect of Bcl-2 overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Influence of bcl-2 on cell death during the cultivation of a Chinese hamster ovary cell line expressing a chimeric antibody.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Regulated overexpression of the survival factor bcl-2 in CHO cells increases viable cell density in batch culture and decreases DNA release in extended fixed-bed cultivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Impact of coexpression and coamplification of sICAM and antiapoptosis determinants bcl-2/bcl-x(L) on productivity, cell survival, and mitochondria number in CHO-DG44 grown in suspension and serum-free media.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Bcl-x(L) mediates increased production of humanized monoclonal antibodies in Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Bcl-xL overexpression does not enhance specific erythropoietin productivity of recombinant CHO cells grown at 33 degrees C and 37 degrees C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Comparison of Bcl-2 to a Bcl-2 deletion mutant for mammalian cells exposed to culture insults

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

A comparison of the properties of a Bcl-xL variant to the wild-type anti-apoptosis inhibitor in mammalian cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Protection of hybridoma cells against apoptosis by a loop domain-deficient Bcl-xL protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Protective effect of viral homologues of bcl-2 on hybridoma cells under apoptosis-inducing conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Dose-dependent reduction of apoptosis in nutrient-limited cultures of NS/0 myeloma cells transfected with the E1B-19K adenoviral gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Apoptosis-resistant E1B-19K-expressing NS/0 myeloma cells exhibit increased viability and chimeric antibody productivity under perfusion culture conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Enhanced cell culture performance using inducible anti-apoptotic genes E1B-19K and Aven in the production of a monoclonal antibody with Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Inhibiting apoptosis in mammalian cell culture using the caspase inhibitor XIAP and deletion mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Study of caspase inhibitors for limiting death in mammalian cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Specific inhibition of caspase-8 and -9 in CHO cells enhances cell viability in batch and fed-batch cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Heat shock proteins: endogenous modulators of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Transfection of NS0 myeloma fusion partner cells with HSP70 gene results in higher hybridoma yield by improving cellular resistance to apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Over-expression of Hsp70 in BHK-21 cells engineered to produce recombinant factor VIII promotes resistance to apoptosis and enhances secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Overexpression of heat shock proteins (HSPs) in CHO cells for extended culture viability and improved recombinant protein production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Aven and Bcl-xL enhance protection against apoptosis for mammalian cells exposed to various culture conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Combining caspase and mitochondrial dysfunction inhibitors of apoptosis to limit cell death in mammalian cell cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Anti-apoptotic genes Aven and E1B-19K enhance performance of BHK cells engineered to express recombinant factor VIII in batch and low perfusion cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Caspase function in programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Influence of co-down-regulation of caspase-3 and caspase-7 by siRNAs on sodium butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Influence of down-regulation of caspase-3 by siRNAs on sodium-butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Inhibition of sodium butyrate-induced apoptosis in recombinant Chinese hamster ovary cells by constitutively expressing antisense RNA of caspase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

RNAi suppression of Bax and Bak enhances viability in fed-batch cultures of CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Transcriptional profiling of apoptotic pathways in batch and fed-batch CHO cell cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Targeting early apoptotic genes in batch and fed-batch CHO cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Links between metabolism and apoptosis in mammalian cells: applications for anti-apoptosis engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Expression of anti-apoptosis genes alters lactate metabolism of Chinese Hamster Ovary cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

BCL2 family in DNA damage and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Regulation of cell proliferation and apoptosis in CHO-K1 cells by the coexpression of c-Myc and Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Optimisation of the cellular metabolism of glycosylation for recombinant proteins produced by Mammalian cell systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Increasing the sialylation of therapeutic glycoproteins: the potential of the sialic acid biosynthetic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Remodeling of sugar chain structures of human interferon-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Genetic engineering of CHO cells producing human interferon-gamma by transfection of sialyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Tissue plasminogen activator coexpressed in Chinese hamster ovary cells with alpha(2,6)-sialyltransferase contains NeuAc alpha(2,6)Gal beta(1,4)Glc-N-AcR linkages

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Genetic engineering of α2,6-sialyltransferase in recombinant CHO cells and its effects on the sialylation of recombinant interferon-γ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

A new Chinese hamster ovary cell line expressing alpha2,6-sialyltransferase used as universal host for the production of human-like sialylated recombinant glycoproteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Modulation of circulatory residence of recombinant acetylcholinesterase through biochemical or genetic manipulation of sialylation levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Construction and characterization of stably transfected BHK-21 cells with human-type sialylation characteristic

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Construction of stable BHK-21 cells coexpressing human secretory glycoproteins and human Gal(beta 1-4)GlcNAc-R alpha 2,6-sialyltransferase alpha 2,6-linked NeuAc is preferentially attached to the Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)-branch of

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Reduction of CMP-N-acetylneuraminic acid hydroxylase activity in engineered Chinese hamster ovary cells using an antisense-RNA strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Removal of sialic acid from a glycoprotein in CHO cell culture supernatant by action of an extracellular CHO cell sialidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

RNA interference of sialidase improves glycoprotein sialic acid content consistency

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Nucleotide sugar transporters of the Golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Enhancing recombinant glycoprotein sialylation through CMP-sialic acid transporter over expression in Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Enhanced sialylation of EPO by overexpression of UDP-GlcNAc 2-epimerase/ManAc kinase containing a sialuria mutation in CHO cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Enhanced sialylation of recombinant erythropoietin in genetically engineered Chinese-hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Glycosylation and biological activity of CAMPATH-1H expressed in different cell lines and grown under different culture conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Modulation of therapeutic antibody effector functions by glycosylation engineering: influence of Golgi enzyme localization domain and co-expression of heterologous beta1, 4-N-acetylglucosaminyltransferase III and Golgi alpha-mannosidase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Glycosylation as a strategy to improve antibody-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Establishment of FUT8 knockout Chinese hamster ovary cells: an ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Engineering Chinese hamster ovary cells to maximize effector function of produced antibodies using FUT8 siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Comparison of cell lines for stable production of fucose-negative antibodies with enhanced ADCC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Establishment of a GDP-mannose 4,6-dehydratase (GMD) knockout host cell line: a new strategy for generating completely non-fucosylated recombinant therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Double knockdown of alpha1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Sialylation of human IgG-Fc carbohydrate by transfected rat alpha2,6-sialyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Using cell engineering and omic tools for the improvement of cell culture processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Initial identification of low temperature and culture stage induction of miRNA expression in suspension CHO-K1 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

MicroRNAs as targets for engineering of CHO cell factories

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Identification and expression analysis of miRNAs during batch culture of HEK-293 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Autophagy contributes to caspase-independent macrophage cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Autophagy in cell death: an innocent convict?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Nutrient deprivation induces autophagy as well as apoptosis in Chinese hamster ovary cell culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Feast or famine: autophagy control and engineering in eukaryotic cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Effect of Akt overexpression on programmed cell death in antibody-producing Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Effect of Bcl-xL overexpression on apoptosis and autophagy in recombinant Chinese hamster ovary cells under nutrient-deprived condition

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

p27Kip1-mediated controlled proliferation technology increases constitutive sICAM production in CHO-DUKX adapted for growth in suspension and serum-free media

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Modulation of cell cycle for enhancement of antibody productivity in perfusion culture of NS0 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Uncoupling of cell growth and proliferation results in enhancement of productivity in p21CIP1-arrested CHO cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Expression of BHRF1 improves survival of murine hybridoma cultures in batch and continuous modes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Inhibiting the apoptosis pathway using MDM2 in mammalian cell cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Enhancement of recombinant protein production in Chinese hamster ovary cells through anti-apoptosis engineering using 30Kc6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Mcl-1 overexpression leads to higher viabilities and increased production of humanized monoclonal antibody in Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Over-expression of hTERT in CHO K1 results in decreased apoptosis and reduced serum dependency

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

The effect of the cell death suppressor vMIA on the production of a recombinant protein in the adenovirus-293 expression system

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Blocking caspase-3 activity with a U6 SnRNA promoter-driven ribozyme enhances survivability of CHO cells cultured in low serum medium and production of interferon-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBA20090363

21 January 2018

Identifiers

DOI

10.1042/BA20090363

1 reference

22 August 2017

1 reference