BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis (Q37761495)

22 August 2017

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title

BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis (English)

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22 August 2017

1

Katia Basso

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22 August 2017

Riccardo Dalla-Favera

series ordinal

2

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22 August 2017

1 January 2010

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22 August 2017

Advances in Immunology

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22 August 2017

105

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22 August 2017

193-210

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Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain

22 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Tracking CD40 signaling during germinal center development

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Acetylation inactivates the transcriptional repressor BCL6.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Control of inflammation, cytokine expression, and germinal center formation by BCL-6

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Pathophysiology of B-cell intrinsic immunoglobulin class switch recombination deficiencies

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Genomic targets of the human c-Myc protein

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Induction of the transcription factors NF-kappa B, AP-1 and NF-AT during B cell stimulation through the CD40 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Recognition DNA sequence of a novel putative transcription factor, BCL6.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

PD-1 and its ligands in tolerance and immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Germinal centres: role in B-cell physiology and malignancy

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Transcriptional analysis of the B cell germinal center reaction

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

CtBP is an essential corepressor for BCL6 autoregulation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

B cell intrinsic TLR signals amplify but are not required for humoral immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

BCL6 controls the expression of the B7-1/CD80 costimulatory receptor in germinal center B cells

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Control of B-cell responses by Toll-like receptors

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

AID is required for germinal center-derived lymphomagenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Humoral immune responses in CD40 ligand-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

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https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

1 reference

7 January 2021

Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Mice deficient for the CD40 ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

Role of beta-catenin in B cell development and function

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2810%2905007-8

7 January 2021

10.1016/S0065-2776(10)05007-8

Identifiers

DOI

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22 August 2017

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PubMed ID

20510734