Germinal centres: role in B-cell physiology and malignancy (Q37039584)

17 August 2017

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title

Germinal centres: role in B-cell physiology and malignancy (English)

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17 August 2017

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Ulf Klein

1

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17 August 2017

Riccardo Dalla-Favera

series ordinal

2

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17 August 2017

1 January 2008

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Nature Reviews Immunology

17 August 2017

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17 August 2017

8

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17 August 2017

22-33

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17 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nri2217

17 August 2017

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cites work

Antigen-driven selection of virgin and memory B cells

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Intraclonal generation of antibody mutants in germinal centres

31 March 2020

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Maturation of the immune response in germinal centers

31 March 2020

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31 March 2020

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Cellular origin of human B-cell lymphomas.

31 March 2020

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Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genes.

31 March 2020

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The dynamic structure of the germinal center.

31 March 2020

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CD19 regulates B cell maturation, proliferation, and positive selection in the FDC zone of murine splenic germinal centers.

31 March 2020

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Imaging of germinal center selection events during affinity maturation

31 March 2020

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In vivo imaging of germinal centres reveals a dynamic open structure

31 March 2020

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Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns.

31 March 2020

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Germinal-center B cells in the zone

31 March 2020

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In vivo imaging studies shed light on germinal-centre development

31 March 2020

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Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.

31 March 2020

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Transcriptional analysis of the B cell germinal center reaction

31 March 2020

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Signatures of the immune response

31 March 2020

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The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

31 March 2020

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Mechanism of antigen-driven selection in germinal centres

31 March 2020

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Isolation and characteristics of tonsil centroblasts with reference to Ig class switching.

31 March 2020

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Identification of a tonsil IgD+ B cell subset with phenotypical and functional characteristics of germinal center B cells

31 March 2020

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Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis

31 March 2020

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Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2

31 March 2020

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FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen

31 March 2020

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Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire.

31 March 2020

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The mechanisms of immune diversification and their disorders

31 March 2020

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Tracking CD40 signaling during germinal center development

31 March 2020

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The physiology of murine germinal center reactions

31 March 2020

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Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B.

31 March 2020

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The transcriptional programme of antibody class switching involves the repressor Bach2.

31 March 2020

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Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein

31 March 2020

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Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells

31 March 2020

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Evolution of autoantibody responses via somatic hypermutation outside of germinal centers

31 March 2020

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Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire

31 March 2020

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Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

31 March 2020

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BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

31 March 2020

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Somatic hypermutation of immunoglobulin genes

31 March 2020

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Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

31 March 2020

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DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

31 March 2020

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

31 March 2020

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

31 March 2020

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

31 March 2020

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Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

31 March 2020

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Transcription-targeted DNA deamination by the AID antibody diversification enzyme

31 March 2020

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Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

31 March 2020

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AID mediates hypermutation by deaminating single stranded DNA.

31 March 2020

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Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

31 March 2020

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Molecular mechanisms of antibody somatic hypermutation.

31 March 2020

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Expression of the AID protein in normal and neoplastic B cells

31 March 2020

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Nuclear and cytoplasmic AID in extrafollicular and germinal center B cells.

31 March 2020

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E-proteins directly regulate expression of activation-induced deaminase in mature B cells

31 March 2020

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The balance between Pax5 and Id2 activities is the key to AID gene expression

31 March 2020

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Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

31 March 2020

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The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation

31 March 2020

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PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells

31 March 2020

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Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation

31 March 2020

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

31 March 2020

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Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma

31 March 2020

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Control of inflammation, cytokine expression, and germinal center formation by BCL-6

31 March 2020

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The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

31 March 2020

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Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice

31 March 2020

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Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.

31 March 2020

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MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation

31 March 2020

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BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms

31 March 2020

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BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

31 March 2020

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BCL6 controls the expression of the B7-1/CD80 costimulatory receptor in germinal center B cells

31 March 2020

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BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells

31 March 2020

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Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR.

31 March 2020

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Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.

31 March 2020

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Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation

31 March 2020

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Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene

31 March 2020

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Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells

31 March 2020

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Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

31 March 2020

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Repression of BCL-6 is required for the formation of human memory B cells in vitro

31 March 2020

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Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor

31 March 2020

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A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma.

31 March 2020

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Acetylation inactivates the transcriptional repressor BCL6.

31 March 2020

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Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization.

31 March 2020

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Role of BCR affinity in T cell dependent antibody responses in vivo

31 March 2020

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High affinity germinal center B cells are actively selected into the plasma cell compartment.

31 March 2020

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C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.

31 March 2020

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AID mutant analyses indicate requirement for class-switch-specific cofactors

31 March 2020

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The role of the non-homologous end-joining pathway in lymphocyte development

31 March 2020

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Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation

31 March 2020

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ICOS is essential for effective T-helper-cell responses

31 March 2020

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ICOS is critical for CD40-mediated antibody class switching

31 March 2020

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TACI and BAFF-R mediate isotype switching in B cells

31 March 2020

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Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.

31 March 2020

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Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation

31 March 2020

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Regulation of B-cell commitment to plasma cells or to memory B cells

31 March 2020

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Heavy-chain class switch does not terminate somatic mutation

31 March 2020

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Pax5: the guardian of B cell identity and function

31 March 2020

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Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells.

31 March 2020

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Loss of Pax5 promotes plasma cell differentiation

31 March 2020

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Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1.

31 March 2020

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Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo

31 March 2020

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Plasma cell differentiation requires the transcription factor XBP-1

31 March 2020

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XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

31 March 2020

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Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function

31 March 2020

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Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells.

31 March 2020

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STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression

31 March 2020

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Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6.

31 March 2020

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Generation of memory B cells and plasma cells in vitro.

31 March 2020

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Mechanisms of chromosomal translocations in B cell lymphomas

31 March 2020

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Mechanisms of B-cell lymphoma pathogenesis

31 March 2020

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Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma

31 March 2020

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Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma.

31 March 2020

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Constitutive expression of AID leads to tumorigenesis

31 March 2020

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AID is required for c-myc/IgH chromosome translocations in vivo

31 March 2020

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Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc.

31 March 2020

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H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.

31 March 2020

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Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice

31 March 2020

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Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

31 March 2020

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Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

31 March 2020

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c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

31 March 2020

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Non-transcriptional control of DNA replication by c-Myc

31 March 2020

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Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas

31 March 2020

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Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma

31 March 2020

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Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells

31 March 2020

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Regulation of the germinal center response by microRNA-155

31 March 2020

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Requirement of bic/microRNA-155 for normal immune function

31 March 2020

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Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

31 March 2020

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Immunoglobulin switch transcript production in vivo related to the site and time of antigen-specific B cell activation

31 March 2020

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DNA polymerases and somatic hypermutation of immunoglobulin genes

31 March 2020

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AID and mismatch repair in antibody diversification

31 March 2020

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Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program

31 March 2020

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Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2217

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Dimensions Publication ID

17 August 2017

1004432568

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Fatcat ID

release_w2okrldcjvgrvcjt74h35flozi

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Fatcat

https://api.fatcat.wiki/v0/release/w2okrldcjvgrvcjt74h35flozi

mapped directly with Wikidata item

24 November 2022

based on heuristic

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