Targeting mTOR in cancer: renal cell is just a beginning (Q37766475)

22 August 2017

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title

Targeting mTOR in cancer: renal cell is just a beginning (English)

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22 August 2017

3

Bernard Escudier

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22 August 2017

Hamdy Azim

1

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PubMed ID

20563661

22 August 2017

Hatem A Azim

series ordinal

2

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22 August 2017

20 June 2010

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22 August 2017

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22 August 2017

5

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22 August 2017

269-280

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22 August 2017

4

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https://scigraph.springernature.com/pub.10.1007/s11523-010-0141-x

22 August 2017

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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12 December 2020

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12 December 2020

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12 December 2020

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

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12 December 2020

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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12 December 2020

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

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12 December 2020

Autophagosomes: biogenesis from scratch?

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

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12 December 2020

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

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12 December 2020

The TOR kinases link nutrient sensing to cell growth

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12 December 2020

mTOR integrates amino acid- and energy-sensing pathways

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12 December 2020

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.

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12 December 2020

Targeting insulin-like growth factor type 1 receptor in cancer therapy.

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12 December 2020

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism.

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12 December 2020

10.1007/S11523-010-0141-X

Identifiers

DOI

1 reference

release_qbdfvoh2sfat3czizedqevd66y

22 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qbdfvoh2sfat3czizedqevd66y

24 November 2022

mapped directly with Wikidata item

PubMed ID

20563661

1 reference

PubMed ID

20563661