Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease (Q37791469)

23 August 2017

Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease (English)

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23 August 2017

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parkinsonian syndrome

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1

Isidre Ferrer

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23 August 2017

Anna Martinez

2

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23 August 2017

Rosa Blanco

series ordinal

3

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23 August 2017

Ester Dalfó

series ordinal

4

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23 August 2017

Margarita Carmona

series ordinal

5

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23 August 2017

23 September 2010

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Journal of Neural Transmission

23 August 2017

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23 August 2017

118

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23 August 2017

5

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23 August 2017

821-839

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https://scigraph.springernature.com/pub.10.1007/s00702-010-0482-8

23 August 2017

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cites work

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

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https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Metals in Alzheimer's and Parkinson's diseases

21 January 2018

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Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Unexpected expression of alpha- and beta-globin in mesencephalic dopaminergic neurons and glial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Cortico-basal ganglia-cortical circuitry in Parkinson's disease reconsidered

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Stages in the development of Parkinson's disease-related pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Cognitive status correlates with neuropathologic stage in Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

DNA methylation regulates adenosine A(2A) receptor cell surface expression levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

The non-motor symptom complex of Parkinson's disease: a comprehensive assessment is essential

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Redox imbalance in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Early alpha-synuclein lipoxidation in neocortex in Lewy body diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Tumor suppressor mutations and growth factor signaling in the pathogenesis of NF1-associated peripheral nerve sheath tumors: II. The role of dysregulated growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Preliminary diagnosis of Parkinson's disease by olfactory bulb pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Incidental Lewy body disease and preclinical Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Alpha-synuclein and the Lewy body disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Evidence in favor of Braak staging of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Localization of specific erythropoietin binding sites in defined areas of the mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Functional effects of neuromelanin and synthetic melanin in model systems.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Modifications of the iron-neuromelanin system in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Early involvement of the cerebral cortex in Parkinson's disease: convergence of multiple metabolic defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Altered mitochondria, energy metabolism, voltage-dependent anion channel, and lipid rafts converge to exhaust neurons in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Active, phosphorylation-dependent mitogen-activated protein kinase (MAPK/ERK), stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p38 kinase expression in Parkinson's disease and Dementia with Lewy bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Comparison of risk factor profiles in incidental Lewy body disease and Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Adenosine A(2A) receptors, dopamine D(2) receptors and their interactions in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Cannabinoids and Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Parkinson's disease and other alpha-synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Increased oxidation of certain glycolysis and energy metabolism enzymes in the frontal cortex in Lewy body diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Alpha-synuclein in Lewy body disease and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Activation of the unfolded protein response in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Alpha-synuclein pathology in the olfactory pathways of dementia patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

A critical reappraisal of current staging of Lewy-related pathology in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Prevalence and impact of cerebrovascular lesions in Alzheimer and lewy body diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. The Royal Kings and Queens Parkinson's Disease Research Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Alteration in alpha-synuclein mRNA expression in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

ELISA reveals a difference in the structure of substantia nigra ferritin in Parkinson's disease and incidental Lewy body compared to control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Proteomic identification of novel proteins in cortical lewy bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Lysosomal degradation of alpha-synuclein in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Lewy body pathology in normal elderly subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Role of alpha-synuclein carboxy-terminus on fibril formation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Transcriptional activation of p62/A170/ZIP during the formation of the aggregates: possible mechanisms and the role in Lewy body formation in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Parkinson's disease and the gut: a well known clinical association in need of an effective cure and explanation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Individual dopaminergic neurons show raised iron levels in Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Ubiquitin-proteasome system and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Mitochondrial dysfunction and oxidative stress in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Alpha-synuclein pathology does not predict extrapyramidal symptoms or dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

The anterior olfactory nucleus in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Occurrence and risk factors for apathy in Parkinson disease: a 4-year prospective longitudinal study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Dysautonomia and cognitive dysfunction in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Non-motor symptoms in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Potential early markers of Parkinson disease in idiopathic REM sleep behavior disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Neurons express hemoglobin alpha- and beta-chains in rat and human brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Association of olfactory dysfunction with risk for future Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Proteomics in Parkinson's disease: current trends, translational snags and future possibilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Abnormalities in metabolic network activity precede the onset of motor symptoms in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

The premotor phase of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Subcellular proteomics reveals neuromelanin granules to be a lysosome-related organelle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Identification of L-ferritin in neuromelanin granules of the human substantia nigra: a targeted proteomics approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

A2A adenosine receptor overexpression and functionality, as well as TNF-alpha levels, correlate with motor symptoms in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Iron contributes to the formation of catechol isoquinolines and oxidative toxicity induced by overdose dopamine in dopaminergic SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Expression of alpha-synuclein in the human brain: relation to Lewy body disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Iron and reactive oxygen species activity in parkinsonian substantia nigra

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Proteomic identification of novel proteins associated with Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Brain iron deficiency and excess; cognitive impairment and neurodegeneration with involvement of striatum and hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Glutathione and Parkinson's disease: is this the elephant in the room?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

Non-motor dysfunction in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0482-8

alpha-synuclein degradation by autophagic pathways: a potential key to Parkinson's disease pathogenesis.

21 January 2018

1 reference

12 December 2020

Pathology associated with sporadic Parkinson's disease--where does it end?

1 reference

12 December 2020

Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease.

1 reference

12 December 2020

Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease

1 reference

12 December 2020

Neuromelanin can protect against iron-mediated oxidative damage in system modeling iron overload of brain aging and Parkinson's disease

1 reference

12 December 2020

1 reference

12 December 2020

Oxidative mechanisms in nigral cell death in Parkinson's disease.

1 reference

12 December 2020

Localization of CKII beta subunits in Lewy bodies of Parkinson's disease

1 reference

12 December 2020

Where does parkinson disease pathology begin in the brain?

1 reference

12 December 2020

Iron dyshomeostasis in Parkinson's disease

1 reference

12 December 2020

A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes.

1 reference

12 December 2020

Evidence of oxidative stress in the neocortex in incidental Lewy body disease

1 reference

12 December 2020

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

1 reference

12 December 2020

Premotor Parkinson's disease: clinical features, detection, and prospects for treatment.

1 reference

12 December 2020

α-synuclein phosphorylation and truncation are normal events in the adult human brain

1 reference

12 December 2020

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1 reference

12 December 2020

Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha-synuclein: Implication for alpha-synucleinopathies

1 reference

12 December 2020

Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages).

1 reference

12 December 2020

NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease.

1 reference

12 December 2020

Potential sources of increased iron in the substantia nigra of parkinsonian patients

1 reference

12 December 2020

In parkinsonian substantia nigra, alpha-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity

1 reference

12 December 2020

Alterations in peptide levels in Parkinson's disease and incidental Lewy body disease.

1 reference

12 December 2020

A longitudinal study of olfactory function in patients with idiopathic Parkinson's disease

1 reference

12 December 2020

1 reference

12 December 2020

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

1 reference

12 December 2020

Lewy body-type degeneration in cardiac plexus in Parkinson's and incidental Lewy body diseases

1 reference

12 December 2020

New face of neuromelanin.

1 reference

12 December 2020

alpha-Synuclein is phosphorylated in synucleinopathy lesions

1 reference

12 December 2020

Extensive axonal Lewy neurites in Parkinson's disease: a novel pathological feature revealed by alpha-synuclein immunocytochemistry

1 reference

12 December 2020

Parkinson's disease: premotor clinico-pathological correlations

1 reference

12 December 2020

Neuropathology of Parkinson's disease

1 reference

12 December 2020

1 reference

12 December 2020

Abnormalities of the electron transport chain in idiopathic Parkinson's disease

1 reference

12 December 2020

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

1 reference

12 December 2020

Altered regulation of iron transport and storage in Parkinson's disease.

1 reference

12 December 2020

Iron dysregulation and Parkinson's disease.

1 reference

12 December 2020

1 reference

12 December 2020

10.1007/S00702-010-0482-8

Identifiers

DOI

1 reference

23 August 2017

1 reference