How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine (Q37793837)

23 August 2017

1 reference

8 February 2021

How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine (English)

1 reference

antineoplastic resistance

23 August 2017

1 reference

14 September 2019

1 reference

19 September 2019

1 reference

PubMed

26 October 2020

genetic heterogeneity

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25 January 2021

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8 February 2021

1

1 reference

23 August 2017

C Swanton

2

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language of work or name

English

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publication date

28 September 2010

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full work available at URL

23 August 2017

12 October 2010

7 references

3 April 2019

30 June 2019

14 September 2019

19 September 2019

26 October 2020

25 January 2021

8 February 2021

5

1 reference

based on heuristic

inferred from page(s)

https://www.nature.com/articles/6605912.pdf

online access status

open access

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20877357

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20877357/pdf/?tool=EBI

22 July 2024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20877357

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20877357/?tool=EBI

22 July 2024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20877357

https://europepmc.org/articles/PMC2967073

22 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20877357

https://europepmc.org/articles/PMC2967073?pdf=render

22 July 2024

online access status

open access

content deliverer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20877357

http://www.nature.com/articles/6605912.pdf

22 July 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.BJC.6605912

http://www.nature.com/articles/6605912

22 July 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.BJC.6605912

British Journal of Cancer

22 July 2024

published in

8 references

23 August 2017

3 April 2019

30 June 2019

14 September 2019

19 September 2019

26 October 2020

25 January 2021

8 February 2021

103

1 reference

23 August 2017

8

1 reference

23 August 2017

1139-1143

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Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported

23 August 2017

7 references

3 April 2019

30 June 2019

14 September 2019

19 September 2019

26 October 2020

25 January 2021

on focus list of Wikimedia project

8 February 2021

copyright status

copyrighted

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ScienceSource

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cites work

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6 September 2017

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Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing

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Resistance to therapy caused by intragenic deletion in BRCA2

6 September 2017

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Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants

6 September 2017

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Random mutations, selected mutations: A PIN opens the door to new genetic landscapes

6 September 2017

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Cancer as an evolutionary and ecological process

6 September 2017

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

6 September 2017

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Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

6 September 2017

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Multidrug resistance in cancer: role of ATP-dependent transporters

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

6 September 2017

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Explaining the high mutation rates of cancer cells to drug and multidrug resistance by chromosome reassortments that are catalyzed by aneuploidy

6 September 2017

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Genetic instabilities in human cancers

6 September 2017

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The mutation rate and cancer

6 September 2017

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Mutator phenotype may be required for multistage carcinogenesis

6 September 2017

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The clonal evolution of tumor cell populations

6 September 2017

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Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

6 September 2017

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Cancer genome sequencing--an interim analysis.

14 September 2017

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Clonal Origin of Human Tumors

14 September 2017

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Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemia

28 September 2017

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Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment.

23 June 2018

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Aneuploidy acts both oncogenically and as a tumor suppressor

23 June 2018

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Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib.

1 September 2018

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A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers.

1 September 2018

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A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy

1 September 2018

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The genetic origin of drug resistance in neoplasms: implications for systemic therapy.

1 September 2018

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THE GENETICS OF BREAST CANCER SUSCEPTIBILITY

1 September 2018

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Circumventing Resistance to Kinase-Inhibitor Therapy

21 January 2018

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Evolutionary dynamics of mutator phenotypes in cancer: implications for chemotherapy

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20877357

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Biochimica et Biophysica Acta

23

1805

105

A Marusyk

2010

1 reference

https://api.crossref.org/works/10.1038/SJ.BJC.6605912

22 July 2024

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23 August 2017

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23 August 2017

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