Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress (Q37802185)

23 August 2017

Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress (English)

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23 August 2017

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S R Bornstein

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23 August 2017

K N Manolopoulos

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23 August 2017

L-O Klotz

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23 August 2017

P Korsten

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23 August 2017

A Barthel

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23 August 2017

language of work or name

English

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publication date

1 November 2010

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23 August 2017

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23 August 2017

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23 August 2017

1046-1052

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23 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/mp.2010.17

23 August 2017

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Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase

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Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia.

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Lipid peroxidation in aging brain and Alzheimer's disease

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The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation

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Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases

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FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics

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Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain.

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Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway.

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Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

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Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion

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Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

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Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation

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FOXO transcription factors in ageing and cancer.

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Molecular mechanisms of insulin resistance

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Novel concepts in insulin regulation of hepatic gluconeogenesis

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New insights into structure and function of mitochondria and their role in aging and disease

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Regulation and termination of NADPH oxidase activity

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Phosphoinositide 3-kinase signaling in the cellular response to oxidative stress

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Healthy aging: regulation of the metabolome by cellular redox modulation and prooxidant signaling systems: the essential roles of superoxide anion and hydrogen peroxide

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Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

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Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

21 January 2018

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Stimulation of selenoprotein P promoter activity in hepatoma cells by FoxO1a transcription factor

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Selenoprotein P expression is controlled through interaction of the coactivator PGC-1alpha with FoxO1a and hepatocyte nuclear factor 4alpha transcription factors

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Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton

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Interaction of FOXO with beta-catenin inhibits beta-catenin/T cell factor activity

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

21 January 2018

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Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.

21 January 2018

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FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism.

21 January 2018

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Regulation of pancreatic beta-cell function by the forkhead protein FoxO1.

21 January 2018

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Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis

21 January 2018

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A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury

21 January 2018

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The glamour and gloom of glycogen synthase kinase-3

21 January 2018

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Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival.

21 January 2018

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Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II.

21 January 2018

1 reference

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Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

The GSK3 hypothesis of Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FMP.2010.17

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase-3 beta and a caspase-9-dependent apoptosis in cerebellar granule neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

Regulation of neuronal cell death by MST1-FOXO1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: a molecular mechanism leading to hepatic insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

Insulin resistance and Alzheimer's disease: molecular links & clinical implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

Caloric restriction and intermittent fasting: two potential diets for successful brain aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

Oxidative alterations in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

7 January 2021

Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

7 January 2021

Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

7 January 2021

Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

7 January 2021

Association of selenoprotein p with Alzheimer's pathology in human cortex

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

7 January 2021

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

7 January 2021

Stress-activated protein kinase/c-jun N-terminal kinase phosphorylates tau protein.

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

7 January 2021

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

7 January 2021

Inflammation and NF-kappaB in Alzheimer's disease and diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FMP.2010.17

7 January 2021

Identifiers

DOI

10.1038/MP.2010.17

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Dimensions Publication ID

23 August 2017

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