The roles of c-rel and interleukin-2 in tolerance: a molecular explanation of self-nonself discrimination (Q37803117)

23 August 2017

The roles of c-rel and interleukin-2 in tolerance: a molecular explanation of self-nonself discrimination (English)

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23 August 2017

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Hsiou-Chi Liou

1

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23 August 2017

Kendall A Smith

series ordinal

2

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23 August 2017

language of work or name

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26 October 2010

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Immunology & Cell Biology

23 August 2017

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23 August 2017

89

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23 August 2017

1

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23 August 2017

27-32

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Actively acquired tolerance of foreign cells

23 August 2017

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

The interleukin-2 T-cell system: a new cell growth model.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

T cell activation determined by T cell receptor number and tunable thresholds.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

How much TCR does a T cell need?

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

The quantal theory of immunity and the interleukin-2-dependent negative feedback regulation of the immune response

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

The quantal theory of immunity

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

The quantal theory of how the immune system discriminates between "self and non-self"

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Differences in susceptibility of mature and immature mouse B lymphocytes to anti-immunoglobulin-induced immunoglobulin suppression in vitro. Possible implications for B-cell tolerance to self

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Distinctions between c-Rel and other NF-kappaB proteins in immunity and disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

NF-kappaB inducible genes BCL-X and cyclin E promote immature B-cell proliferation and survival.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Cutting edge: B cell antigen receptor signaling occurs outside lipid rafts in immature B cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Floating the raft hypothesis: the roles of lipid rafts in B cell antigen receptor function

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

BCR-mediated apoptosis associated with negative selection of immature B cells is selectively dependent on Pten.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Transcriptional mechanisms underlying lymphocyte tolerance.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Interleukin 2 receptor signaling regulates the perforin gene through signal transducer and activator of transcription (Stat)5 activation of two enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

c-Rel is essential for B lymphocyte survival and cell cycle progression.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiation

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Interleukin-2: inception, impact, and implications

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Interleukin-2 deficient mice: a new model to study autoimmunity and self-tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

The control of CD4+CD25+Foxp3+ regulatory T cell survival

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.120

Neonates support lymphopenia-induced proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

Cutting edge: Paracrine, but not autocrine, IL-2 signaling is sustained during early antiviral CD4 T cell response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

The initial phase of an immune response functions to activate regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

The alphabeta T cell receptor is an anisotropic mechanosensor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

Immune responses in interleukin-2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

Induction of self-tolerance in mature peripheral B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

Receptor-mediated inactivation of early B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

Biallelic expression of the IL-2 locus under optimal stimulation conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

7 January 2021

c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

7 January 2021

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

7 January 2021

c-Rel is required for the protection of B cells from antigen receptor-mediated, but not Fas-mediated, apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

7 January 2021

c-Rel regulation of the cell cycle in primary mouse B lymphocytes

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https://api.crossref.org/works/10.1038%2FICB.2010.120

7 January 2021

Cyclin E and Bcl-xL cooperatively induce cell cycle progression in c-Rel-/- B cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

7 January 2021

B cell receptor-induced apoptosis in primary transitional murine B cells: signaling requirements and modulation by T cell help

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

7 January 2021

Phosphatidylinositol 3-kinase and NF-kappa B/Rel are at the divergence of CD40-mediated proliferation and survival pathways

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

7 January 2021

Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

7 January 2021

The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

7 January 2021

Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

7 January 2021

Interleukin-2 is indispensable for development of immunological self-tolerance

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https://api.crossref.org/works/10.1038%2FICB.2010.120

7 January 2021

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

7 January 2021

Tracing the action of IL-2 in tolerance to islet-specific antigen

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.120

7 January 2021

Identifiers

DOI

10.1038/ICB.2010.120

1 reference

release_gdnzrpat3zcwljrkw2xzpdzfqy

23 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/gdnzrpat3zcwljrkw2xzpdzfqy

24 November 2022

mapped directly with Wikidata item

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