Investigating monogenic and complex diseases with pluripotent stem cells (Q37851013)

24 August 2017

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title

Investigating monogenic and complex diseases with pluripotent stem cells (English)

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24 August 2017

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4

George Q Daley

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Patrick Cahan

object named as

Patrick Cahan

series ordinal

3

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Hao Zhu

object named as

Hao Zhu

series ordinal

1

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M William Lensch

series ordinal

2

object named as

M William Lensch

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24 August 2017

language of work or name

English

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publication date

9 March 2011

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24 August 2017

published in

Nature Reviews Genetics

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24 August 2017

volume

12

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24 August 2017

issue

4

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24 August 2017

page(s)

266-275

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Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons

24 August 2017

cites work

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Disease-specific induced pluripotent stem cells

21 January 2018

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Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients

21 January 2018

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A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

21 January 2018

1 reference

Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells.

21 January 2018

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Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage

21 January 2018

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Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells

21 January 2018

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Prospects for pluripotent stem cell-derived cardiomyocytes in cardiac cell therapy and as disease models

21 January 2018

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Patient-specific induced pluripotent stem-cell models for long-QT syndrome

21 January 2018

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Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes

21 January 2018

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Common variants at ten loci modulate the QT interval duration in the QTSCD Study

21 January 2018

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Common variants at ten loci influence QT interval duration in the QTGEN Study

21 January 2018

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Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells.

21 January 2018

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The genetics of type 2 diabetes: what have we learned from GWAS?

21 January 2018

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21 January 2018

How to make beta cells?

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Pathways to new beta cells

21 January 2018

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Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells

21 January 2018

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The tumorigenicity of human embryonic stem cells

21 January 2018

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Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study

21 January 2018

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Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

21 January 2018

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A mouse model for Down syndrome exhibits learning and behaviour deficits.

21 January 2018

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Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera

21 January 2018

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Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation

21 January 2018

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Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

21 January 2018

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Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

21 January 2018

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An overview of the pathology and approaches to tissue engineering

21 January 2018

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Strengths and limitations of the neurosphere culture system

21 January 2018

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The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells

21 January 2018

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Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis

21 January 2018

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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

21 January 2018

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Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

21 January 2018

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

21 January 2018

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Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

21 January 2018

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Human-animal chimeras in biomedical research

21 January 2018

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Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice

21 January 2018

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Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

21 January 2018

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Developmental and species-divergent globin switching are driven by BCL11A

21 January 2018

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Inactivation of the Fto gene protects from obesity

21 January 2018

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Overexpression of Fto leads to increased food intake and results in obesity

21 January 2018

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A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

21 January 2018

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Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies

21 January 2018

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A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells

21 January 2018

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Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human

21 January 2018

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21 January 2018

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The study of eQTL variations by RNA-seq: from SNPs to phenotypes

21 January 2018

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Epigenetic memory in induced pluripotent stem cells

21 January 2018

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Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells

21 January 2018

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Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

21 January 2018

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Conservation of IGF2-H19 and IGF2R imprinting in sheep: effects of somatic cell nuclear transfer

21 January 2018

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Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

21 January 2018

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A ROCK inhibitor permits survival of dissociated human embryonic stem cells

21 January 2018

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Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells

21 January 2018

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Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations

21 January 2018

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Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells

21 January 2018

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Establishment in culture of pluripotential cells from mouse embryos

21 January 2018

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Embryonic stem cell lines derived from human blastocysts

21 January 2018

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

21 January 2018

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Induced pluripotent stem cell lines derived from human somatic cells

21 January 2018

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Reprogramming of human somatic cells to pluripotency with defined factors

21 January 2018

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Nuclear reprogramming to a pluripotent state by three approaches

21 January 2018

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Progress toward the clinical application of patient-specific pluripotent stem cells

21 January 2018

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Epigenetic reprogramming and induced pluripotency

21 January 2018

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Cellular reprogramming and pluripotency induction

21 January 2018

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Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation

21 January 2018

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Analysis of the 10q11 cancer risk locus implicates MSMB and NCOA4 in human prostate tumorigenesis

21 January 2018

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Embryonic stem cells as a platform for analyzing neural gene transcription

21 January 2018

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Induced pluripotent stem cells from individuals with recessive dystrophic epidermolysis bullosa

21 January 2018

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Methods for making induced pluripotent stem cells: reprogramming à la carte

31 March 2020

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Transgenic analysis of a 100-kb human beta-globin cluster-containing DNA fragment propagated as a bacterial artificial chromosome

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21386866

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Induced pluripotent stem cells for modelling human diseases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21386866

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Turning straw into gold: directing cell fate for regenerative medicine

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21386866

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRG2951

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Dimensions Publication ID

24 August 2017

1032474767

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1 reference