The genetics of type 2 diabetes: what have we learned from GWAS? (Q37811045)

23 August 2017

The genetics of type 2 diabetes: what have we learned from GWAS? (English)

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genome-wide association study

23 August 2017

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type 2 diabetes

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author name string

Liana K Billings

series ordinal

1

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23 August 2017

Jose C Florez

series ordinal

2

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23 August 2017

language of work or name

English

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publication date

1 November 2010

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23 August 2017

19

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Annals of the New York Academy of Sciences

inferred from page(s)

published in

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23 August 2017

1212

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23 August 2017

59-77

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describes a project that uses

23 August 2017

genome-wide association study

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Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.

inferred from title

cites work

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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

6 September 2017

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Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

6 September 2017

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Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function

6 September 2017

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Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.

6 September 2017

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Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

6 September 2017

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Genome-wide association of lipid-lowering response to statins in combined study populations

6 September 2017

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Gene--environment-wide association studies: emerging approaches

6 September 2017

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The 1000 Genomes Project: new opportunities for research and social challenges

6 September 2017

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Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

6 September 2017

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A map of open chromatin in human pancreatic islets

6 September 2017

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

6 September 2017

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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

6 September 2017

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Finding the missing heritability of complex diseases

6 September 2017

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The clinical application of genetic testing in type 2 diabetes: a patient and physician survey

6 September 2017

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Diabetes Risk Perception and Intention to Adopt Healthy Lifest yles Among Primary Care Patients

6 September 2017

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Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease

6 September 2017

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Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

6 September 2017

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Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion

6 September 2017

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Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?

6 September 2017

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New susceptibility locus for coronary artery disease on chromosome 3q22.3.

6 September 2017

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Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands

6 September 2017

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Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

6 September 2017

1 reference

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A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

6 September 2017

1 reference

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Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

6 September 2017

1 reference

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Variants in MTNR1B influence fasting glucose levels

6 September 2017

1 reference

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Common variants at 30 loci contribute to polygenic dyslipidemia

6 September 2017

1 reference

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Clinical risk factors, DNA variants, and the development of type 2 diabetes

6 September 2017

1 reference

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Genotype score in addition to common risk factors for prediction of type 2 diabetes

6 September 2017

1 reference

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Personal genomes: The case of the missing heritability

6 September 2017

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Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.

6 September 2017

1 reference

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Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations

6 September 2017

1 reference

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Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes

6 September 2017

1 reference

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Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients

6 September 2017

1 reference

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Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels

6 September 2017

1 reference

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Newly identified loci highlight beta cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes?

6 September 2017

1 reference

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Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein

6 September 2017

1 reference

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6 September 2017

1 reference

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Genome-wide association studies for complex traits: consensus, uncertainty and challenges

6 September 2017

1 reference

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Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Estimation of the multiple testing burden for genomewide association studies of nearly all common variants

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

A second generation human haplotype map of over 3.1 million SNPs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

A common variant of HMGA2 is associated with adult and childhood height in the general population

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

The new type 2 diabetes gene TCF7L2

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

6 September 2017

1 reference

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

6 September 2017

1 reference

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels

6 September 2017

1 reference

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A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

A genome-wide association study identifies novel risk loci for type 2 diabetes

6 September 2017

1 reference

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Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone

6 September 2017

1 reference

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A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses

6 September 2017

1 reference

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In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion

6 September 2017

1 reference

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Activating mutations in the ABCC8 gene in neonatal diabetes mellitus

6 September 2017

1 reference

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TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

6 September 2017

1 reference

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Genetic basis of maturity-onset diabetes of the young

6 September 2017

1 reference

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Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

6 September 2017

1 reference

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A haplotype map of the human genome

6 September 2017

1 reference

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Sequence variation in PPARG may underlie differential response to troglitazone

6 September 2017

1 reference

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ZnT-8, a pancreatic beta-cell-specific zinc transporter

6 September 2017

1 reference

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Obesity and metabolic syndrome in circadian Clock mutant mice

6 September 2017

1 reference

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Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules

6 September 2017

1 reference

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Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-gamma2 gene variant: results from the Troglitazone in Prevention of

6 September 2017

1 reference

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Control of pancreas and liver gene expression by HNF transcription factors

6 September 2017

1 reference

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The International HapMap Project

6 September 2017

1 reference

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Genetic cause of hyperglycaemia and response to treatment in diabetes

6 September 2017

1 reference

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Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2.

6 September 2017

1 reference

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Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

6 September 2017

1 reference

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Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance

6 September 2017

1 reference

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A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms

6 September 2017

1 reference

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Initial sequencing and analysis of the human genome

6 September 2017

1 reference

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The Sequence of the Human Genome

6 September 2017

1 reference

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The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Diabetes-associated mutations in a beta-cell transcription factor destabilize an antiparallel "mini-zipper" in a dimerization interface

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study

6 September 2017

1 reference

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An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

6 September 2017

1 reference

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TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Architectural variations of inducible eukaryotic promoters: preset and remodeling chromatin structures

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Differential effects of monounsaturated, polyunsaturated and saturated fat ingestion on glucose-stimulated insulin secretion, sensitivity and clearance in overweight and obese, non-diabetic humans.

23 June 2018

1 reference

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Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Translating TCF7L2: from gene to function.

1 September 2018

1 reference

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Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study

1 September 2018

1 reference

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Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.

1 September 2018

1 reference

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Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study

1 September 2018

1 reference

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Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.

1 September 2018

1 reference

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The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Effects of Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma2 gene on rosiglitazone response in type 2 diabetes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Role of insulin-like growth factor iin maintaining normal glucose homeostasis

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

A genome scan for loci linked to quantitative insulin traits in persons without diabetes: the Framingham Offspring Study

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Analysis of the relationship between the Pro12Ala variant in the PPAR-gamma2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

p57(KIP2) expression in normal islet cells and in hyperinsulinism of infancy.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Putative roles of melatonin in glucose regulation.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3057517

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

1 September 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2010.05838.X

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2010.05838.X

The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2010.05838.X

Evaluation of Common Variants in the Six Known Maturity-Onset Diabetes of the Young (MODY) Genes for Association With Type 2 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2010.05838.X

Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2010.05838.X

TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2010.05838.X

A genetic link between type 2 diabetes and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2010.05838.X

Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.2010.05838.X

Evidence for a circadian rhythm of insulin secretion

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21091714

12 December 2020

inferred from PubMed ID database lookup

Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21091714

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1111/J.1749-6632.2010.05838.X

1 reference

23 August 2017

1 reference

23 August 2017

1 reference