Hax-1: a regulator of calcium signaling and apoptosis progression with multiple roles in human disease (Q37851497)

24 August 2017

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title

Hax-1: a regulator of calcium signaling and apoptosis progression with multiple roles in human disease (English)

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24 August 2017

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Thomas Simmen

1

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24 August 2017

language of work or name

English

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publication date

11 March 2011

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Expert Opinion on Therapeutic Targets

24 August 2017

published in

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24 August 2017

volume

15

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24 August 2017

issue

6

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24 August 2017

page(s)

741-751

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The coiled-coil domain is required for HS1 to bind to F-actin and activate Arp2/3 complex

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Syk-mediated tyrosine phosphorylation is required for the association of hematopoietic lineage cell-specific protein 1 with lipid rafts and B cell antigen receptor signalosome complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Hax1 lacks BH modules and is peripherally associated to heavy membranes: implications for Omi/HtrA2 and PARL activity in the regulation of mitochondrial stress and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Expression and tissue distribution of mouse Hax1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Induction of apoptosis by Hax-1 siRNA in melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

N(alpha)-tosyl-L-phenylalanine chloromethyl ketone induces caspase-dependent apoptosis in transformed human B cell lines with transcriptional down-regulation of anti-apoptotic HS1-associated protein X-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

HAX-1: a multifunctional protein with emerging roles in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

An anti-apoptotic protein, Hax-1, inhibits the HIV-1 rev function by altering its sub-cellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

HAX-1 overexpression, splicing and cellular localization in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

The 3' untranslated region of human vimentin mRNA interacts with protein complexes containing eEF-1gamma and HAX-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Hairpin structure within the 3'UTR of DNA polymerase beta mRNA acts as a post-transcriptional regulatory element and interacts with Hax-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Phospholamban interacts with HAX-1, a mitochondrial protein with anti-apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

The anti-apoptotic protein HAX-1 is a regulator of cardiac function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) forms complexes with a cellular anti-apoptosis protein Bcl-2 or its EBV counterpart BHRF1 through HS1-associated protein X-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Molecular interaction between HAX-1 and XIAP inhibits apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Human immunodeficiency virus type 1 Vpr interacts with antiapoptotic mitochondrial protein HAX-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Hepatitis C virus core protein and cellular protein HAX-1 promote 5-fluorouracil-mediated hepatocyte growth inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Epstein-Barr virus nuclear antigen 5 interacts with HAX-1, a possible component of the B-cell receptor signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Prohibitins and the functional compartmentalization of mitochondrial membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Prohibitin function within mitochondria: essential roles for cell proliferation and cristae morphogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Vi polysaccharide of Salmonella typhi targets the prohibitin family of molecules in intestinal epithelial cells and suppresses early inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Structural and functional link between the mitochondrial network and the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Calcium pumps in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Molecular regulation of phospholamban function and expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Oxidative protein folding in the endoplasmic reticulum: tight links to the mitochondria-associated membrane (MAM).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Compartmentalized signalling: Ca2+ compartments, microdomains and the many facets of Ca2+ signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Increased frequency of calcium waves in Xenopus laevis oocytes that express a calcium-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Anti-apoptotic protein Bcl-2 interacts with and destabilizes the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Displacement of SERCA from SR lipid caveolae-related domains by Bcl-2: a possible mechanism for SERCA inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

The subcellular distribution of calnexin is mediated by PACS-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Cytosolic phosphorylation of calnexin controls intracellular Ca(2+) oscillations via an interaction with SERCA2b

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Existence of multiple isoforms of HS1-associated protein X-1 in murine and human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Distant homologs of anti-apoptotic factor HAX1 encode parvalbumin-like calcium binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

HAX-1, identified by differential display reverse transcription polymerase chain reaction, is overexpressed in lesional psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Novel genetic etiologies of severe congenital neutropenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Homozygous HAX1 mutations in severe congenital neutropenia patients with sporadic disease: a novel mutation in two unrelated British kindreds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

A novel HAX1 gene mutation in severe congenital neutropenia (SCN) associated with neurological manifestations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Novel HAX1 gene mutations associated to neurodevelopment abnormalities in two Italian patients with severe congenital neutropenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Central nervous system involvement in severe congenital neutropenia: neurological and neuropsychological abnormalities associated with specific HAX1 mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

21 January 2018

Eponym. Kostmann disease

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

G-CSF receptor mutations in patients with congenital neutropenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Clinical implications of ELA2-, HAX1-, and G-CSF-receptor (CSF3R) mutations in severe congenital neutropenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Survivin expression in the bone marrow of patients with severe congenital neutropenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

HAX1 deficiency: Impact on lymphopoiesis and B-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

HS1-Associated Protein X-1 Regulates Carcinoma Cell Migration and Invasion via Clathrin-Mediated Endocytosis of Integrin αvβ6

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

Compound heterozygousHAX1mutations in a Swedish patient with severe congenital neutropenia and no neurodevelopmental abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.561787

10.1517/14728222.2011.561787

21 January 2018

Identifiers

DOI

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24 August 2017

1 reference